Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Wayne S Sossin"'
Autor:
Margaret H Hastings, Katrina Gong, Alexander Freibauer, Caitlin Courchesne, Xiaotang Fan, Wayne S Sossin
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186646 (2017)
Calpains are a family of intracellular proteases defined by a conserved protease domain. In the marine mollusk Aplysia californica, calpains are important for the induction of long-term synaptic plasticity and memory, at least in part by cleaving pro
Externí odkaz:
https://doaj.org/article/7b1655ac47094ea5b6ac8cebc69e8f73
Autor:
Carole A Farah, Bryan Rourke, Unkyung Shin, Larissa Ferguson, María José Luna, Wayne S Sossin
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168411 (2016)
Activation of the novel PKC Apl II in sensory neurons by serotonin (5HT) underlies the ability of 5HT to reverse synaptic depression, but the pathway from 5HT to PKC Apl II activation remains unclear. Here we find no evidence for the Aplysia-specific
Externí odkaz:
https://doaj.org/article/152d54b3023f432184e943db88fff1b6
Autor:
Tyler William Dunn, Wayne S Sossin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136907 (2015)
The defensive withdrawal reflexes of Aplysia are important behaviors for protecting the animal from predation. Habituation and dishabituation allow for experience-dependent tuning of these reflexes and the mechanisms underlying these forms of behavio
Externí odkaz:
https://doaj.org/article/faff3a201a1d4447b007ba568f2b91c6
Autor:
John Dyer, Wayne S Sossin
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74085 (2013)
The rate-limiting step(s) of translation in the nervous system have not been clearly identified. We have been examining this question in the cell body of the Aplysia sensory neuron, where translational regulation is important for the regulation of sy
Externí odkaz:
https://doaj.org/article/5f0ce62afdd6446d8014f9611a4b7d17
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 12, p e1002324 (2011)
The sensory-motor neuron synapse of Aplysia is an excellent model system for investigating the biochemical changes underlying memory formation. In this system, training that is separated by rest periods (spaced training) leads to persistent changes i
Externí odkaz:
https://doaj.org/article/5d61f4c492e94938933c4ebf98bb9dfc
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The presynaptic release apparatus can be specialized to enable specific synaptic functions. Habituation is the diminishing of a physiological response to a frequently repeated stimulus and in Aplysia, habituation to touch is mediated by a de
Externí odkaz:
https://doaj.org/article/9cef5b22ce3c4a4ea70daf90df9f8039
Autor:
Oliver Hardt, Wayne S. Sossin
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2020)
A number of observations in recent years demonstrates that across all levels of organization, memory is inherently fluid. On the cognitive-behavioral level, the innocent act of remembering can irrevocably alter the contents of established long-term m
Externí odkaz:
https://doaj.org/article/b28cc20a040744eaa719d1812459e5c6
Autor:
Mina N. Anadolu, Jingyu Sun, Jewel Tian-Yi Li, Tyson E. Graber, Joaquin Ortega, Wayne S. Sossin
Puromycin is covalently added to the nascent chain of proteins by the peptidyl transferase activity of the ribosome and this event is normally followed by the dissociation of the puromycylated peptide. It was postulated that blocking the translocatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a041a688b1bf824110c202ff3888183
https://doi.org/10.1101/2023.05.02.539124
https://doi.org/10.1101/2023.05.02.539124
Autor:
Congyao Zha, Wayne S. Sossin
Publikováno v:
Journal of neurochemistryREFERENCES. 163(6)
Experience triggers molecular cascades in organisms (learning) that lead to alterations (memory) to allow the organism to change its behavior based on experience. Understanding the molecular mechanisms underlying memory, particularly in the nervous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77c57b3c95d5a1f5288501e189f7ca2
https://pubmed.ncbi.nlm.nih.gov/36326567
https://pubmed.ncbi.nlm.nih.gov/36326567
Publikováno v:
Neuroscience. 465:128-141
The Small Optic Lobe (SOL) family of calpains are intracellular cysteine proteases that are expressed in the nervous system and play an important role in neuronal development in both Drosophila, where loss of this calpain leads to the eponymous small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a087b32982b61de325a5345845ef0d
https://doi.org/10.1016/j.neuroscience.2021.04.023
https://doi.org/10.1016/j.neuroscience.2021.04.023