Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Wayne R. Giles"'
Autor:
Hiroaki Kito, Reiko Kawagishi, Takusei Ryu, Kyoko Endo, Junko Kajikuri, Wayne R. Giles, Susumu Ohya
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 3, Pp 142-152 (2023)
Osteoblasts synthesize and deposit essential components of the extracellular bone matrix and collagen scaffolds, leading to mineralized bone formation. Therefore, the proliferation of preosteoblasts (precursors of mature osteoblasts) helps in regulat
Externí odkaz:
https://doaj.org/article/9a31304f347946afabbab9fefde8ed65
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract In the heart, electrophysiological dysregulation arises from defects at many biological levels (from point mutations in ion channel proteins to gross structural abnormalities). These defects disrupt the normal pattern of electrical activatio
Externí odkaz:
https://doaj.org/article/b8676228161f4e678ffb91bee85f052b
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/b38fda03749144a8a11ea69d83d2548d
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Computational modeling has contributed significantly to present understanding of cardiac electrophysiology including cardiac conduction, excitation-contraction coupling, and the effects and side-effects of drugs. However, the accuracy of in silico an
Externí odkaz:
https://doaj.org/article/e1dc4808113a4e149fe9b0b93688224b
Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Although plasma electrolyte levels are quickly and precisely regulated in the mammalian cardiovascular system, even small transient changes in K+, Na+, Ca2+, and/or Mg2+ can significantly alter physiological responses in the heart, blood vessels, and
Externí odkaz:
https://doaj.org/article/59d20b3f84f64d379020292012a4abd5
Publikováno v:
Cells, Vol 9, Iss 7, p 1577 (2020)
An improved understanding of fundamental physiological principles and progressive pathophysiological processes in human articular joints (e.g., shoulders, knees, elbows) requires detailed investigations of two principal cell types: synovial fibroblas
Externí odkaz:
https://doaj.org/article/f5baecd0f1e448cdb1de757b229211a9
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Human transplant programs provide significant opportunities for detailed in vitro assessments of physiological properties of selected tissues and cell types. We present a semi-quantitative study of the fundamental electrophysiological/biophysical cha
Externí odkaz:
https://doaj.org/article/ebe40a63390e46a989f4902cc2b66bbf
Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Developing effective and safe anti-AF drugs remains an unmet challenge. Simultaneous block of both atrial-specific ultra-rapid delayed rectifier potassium (K+) current (IKur) and the Na+
Externí odkaz:
https://doaj.org/article/8ef4672e9e8d432190d42136bcedcd41
Autor:
Aru Narendran, Aarthi Jayanthan, Darrell D. Belke, Wayne R. Giles, Satbir Thakur, Mohit Jain, Umberto Banderali
Publikováno v:
Current Eye Research. 47:426-435
PURPOSE Retinoblastoma is the most frequent intraocular cancer in children. It is also one of the most common causes for enucleation and carries a significant morbidity rate in affected individuals. Hence, studies on its pathophysiological and growth
Autor:
Matei Zaharia, Wouter-Jan Rappel, Wayne R. Giles, Tina Baykaner, Paul J. Wang, Firas Abuzaid, Paul Clopton, David E. Krummen, Sanjiv M. Narayan, Christian Meyer, Cesare Corrado, Anojan Selvalingam, Mahmood Alhusseini, Steven A. Niederer, Albert J. Rogers, Peter Bailis
Publikováno v:
Circulation Research. 128:172-184
Rationale: Susceptibility to VT/VF (ventricular tachycardia/fibrillation) is difficult to predict in patients with ischemic cardiomyopathy either by clinical tools or by attempting to translate cellular mechanisms to the bedside. Objective: To develo