Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Wayne R. Fitzgibbon"'
Autor:
Kristine Y. DeLeon-Pennell, Miguel Troncoso, Mark Domondon, Yuliia Kashyrina, Iuliia Polina, Wayne R. Fitzgibbon, Rebecca Fox, Ryan Schibalski, Daria V. Ilatovskaya, Valeriia Y. Vasileva, Monika Gooz, Anastasia V. Sudarikova
Publikováno v:
Am J Physiol Renal Physiol
Diuretics and renin-angiotensin system blockers are often insufficient to control the blood pressure (BP) in salt-sensitive (SS) subjects. Abundant data support the proposal that the level of atrial natriuretic peptide may correlate with the pathogen
Autor:
Jifeng Huang, Zhang Li, Kurt A. Zimmerman, Dustin Z. Revell, Michal Mrug, Lan He, Gary Hardiman, Bradley K. Yoder, E. Starr Hazard, Wayne R. Fitzgibbon, P. Darwin Bell, Jung-Shan Hsu, Takamitsu Saigusa
Publikováno v:
Kidney360
Background Autosomal dominant polycystic kidney disease is caused by genetic mutations in PKD1 or PKD2. Macrophages and their associated inflammatory cytokines promote cyst progression; however, transcription factors within macrophages that control c
Autor:
Juan Carlos Q Velez, Michael G Janech, Megan P Hicks, Thomas A Morinelli, Jessalyn Rodgers, Sally E Self, John M Arthur, Wayne R Fitzgibbon
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110083 (2014)
Unopposed angiotensin (Ang) II-mediated cellular effects may lead to progressive glomerulosclerosis. While Ang-II can be locally generated in the kidneys, we previously showed that glomerular podocytes primarily convert Ang-I, the precursor of Ang-II
Externí odkaz:
https://doaj.org/article/bebc2c95666648149b9bfbe4dbd41c32
Autor:
Christopher M. Furcht, Joshua H. Lipschutz, Pei Wen, Pankaj Srivastava, Deepak Nihalani, Ashish K. Solanki, Matthew J. Lazzara, Zhe Han, Lawrence B. Holzman, Bushra Rahman, Sang Ho Kwon, Glenn P. Lobo, Wayne R. Fitzgibbon, Avinash Singh, Ehtesham Arif
When activated, slit diaphragm proteins NEPHRIN and NEPH1 enable signaling pathways leading to podocyte actin cytoskeleton reorganization, which is critical for podocyte recovery from injury. However, the mechanisms through which these proteins are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07379321bab91b23b04b151b0acb7870
Autor:
Adam E. Mullick, Marlene A. Bunni, Michael R. Zile, Wayne R. Fitzgibbon, Catalin F. Baicu, Takamitsu Saigusa, Yujing Dang
Publikováno v:
American Journal of Physiology-Renal Physiology. 314:F210-F218
The intrarenal renin angiotensin system (RAS) is activated in polycystic kidney disease. We have recently shown in the Pkd1 mouse that Gen 2 antisense oligonucleotide (ASO), which suppresses angiotensinogen (Agt) synthesis, is efficacious in slowing
Autor:
Bushra Rahman, Ehtesham Arif, Pei Wen, Zhe Han, Joshua H. Lipschutz, Avinash Singh, Sang Ho Kwon, Deepak Nihalani, Glenn P. Lobo, Pankaj Srivastava, Ashish K. Solanki, Wayne R. Fitzgibbon, Milos N. Budisavljevic, Christopher M. Furcht, Lawrence B. Holzman, Matthew J. Lazzara
Publikováno v:
The Journal of Biological Chemistry
Phosphorylation (activation) and dephosphorylation (deactivation) of the slit diaphragm proteins NEPHRIN and NEPH1 are critical for maintaining the kidney epithelial podocyte actin cytoskeleton and, therefore, proper glomerular filtration. However, t
Autor:
Milos N. Budisavljevic, Rick G. Schnellmann, Michael G. Janech, Bushra Rahman, Pankaj Srivastava, Peifeng Deng, Deepak Nihalani, Ashish K. Solanki, Wayne R. Fitzgibbon, Justin B. Collier, Sang Ho Kwon, Ehtesham Arif, Michael R. Zile, Catalin F. Baicu, Judit Megyesi
Publikováno v:
Kidney Int
Podocytes have limited ability to recover from injury. Here, we demonstrate that increased mitochondrial biogenesis, to meet the metabolic and energy demand of a cell, accelerates podocyte recovery from injury. Analysis of events induced during podoc
Publikováno v:
Journal of clinical & experimental nephrology
Background: Chronic in-center hemodialysis (HD) patients may experience more morbidity and mortality after the weekend. Since our Veterans Administration Hospital HD unit is closed on the weekend, non-traditional HD schedules were created. Some sched
Autor:
Michael G. Janech, Evelyn Bruner, Deepak Nihalani, Megan P. Hicks, Milos N. Budisavljevic, Ehtesham Arif, Jessalyn Rodgers, Juan Carlos Q. Velez, Wayne R. Fitzgibbon, John M. Arthur, Carl Atkinson
Publikováno v:
Journal of the American Society of Nephrology : JASN. 28(7)
Aminopeptidase A (APA) is expressed in glomerular podocytes and tubular epithelia and metabolizes angiotensin II (AngII), a peptide known to promote glomerulosclerosis. In this study, we tested whether APA expression changes in response to progressiv
Autor:
Brad Yoder, Lisa M. Guay-Woodford, Sandra K. Gilley, Wayne R. Fitzgibbon, Kelli M. Sas, Ryan J. Reichert, P. Darwin Bell, Mehmet Bilgen, May Y. Amria, Courtney J. Haycraft, Amber Houston, John J. Bissler, Peter Cheng Te Chou, Gene P. Siegal, Brian J. Siroky, Antine E. Stenbit
Publikováno v:
Journal of the American Society of Nephrology. 22:839-848
Primary cilia dysfunction alters renal tubular cell proliferation and differentiation and associates with accelerated cyst formation in polycystic kidney disease. However, the mechanism leading from primary ciliary dysfunction to renal cyst formation