Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Wayne P. Kelley"'
Autor:
Shawn Novick, Ping Yin, Juliana Kretsinger, Martin H. Gastens, Margaret Ruesch, Ming Zeng, Eileen Berkay, Luca Benetti, John T. Stults, Ann Subashi, Barbara Rellahan, Neha Frantz, Wayne P. Kelley, Corné J.M. Stroop, Laura Pack, David Cirelli, Michael J. Lewis
Publikováno v:
Journal of Pharmaceutical Sciences. 110:771-784
Commercial specifications for a new biotherapeutic product are a critical component of the product's overall control strategy that ensures safety and efficacy. This paper describes strategies for setting commercial specifications as proposed by a con
Autor:
Neha Frantz, Ping Yin, Shawn Novick, Daniela Stranges, Juliana Kretsinger, Barbara Rellahan, Martin H. Gastens, Wayne P. Kelley, Scott A. Hart, Bob Kitchen, Corné J.M. Stroop
Publikováno v:
Journal of pharmaceutical sciences. 108(4)
Early-phase specifications are established to ensure that materials used in clinical studies have appropriate product quality, reducing the risk of harm to patients. Currently, guidance is available for specification setting practices at commercial p
Autor:
Joseph R. Schulz, Jonathan V. Sweedler, William F. Gilly, Wayne P. Kelley, Jennifer A. Jakubowski
Publikováno v:
Biochemistry. 45:14212-14222
We describe structural properties and biological activities of two related O-glycosylated peptide toxins isolated from injected (milked) venom of Conus striatus, a piscivorous snail that captures prey by injecting a venom that induces a violent, spas
Autor:
Jonathan V. Sweedler, Ken R. Gayler, Jennifer A. Jakubowski, Bruce G. Livett, Wayne P. Kelley, David A. Keays, Jon-Paul Bingham, David W. Sandall
Publikováno v:
Journal of Mass Spectrometry. 39:548-557
A combination of cDNA cloning and detailed mass spectrometric analyses was employed to identify novel conotoxins from Conus victoriae. Eleven conotoxin sequences were determined using molecular methods: one belonging to the A superfamily (Vc1.1), six
Autor:
Stefan R. Pulver, Jonathan V. Sweedler, Andrew E. Christie, Lingjun Li, Wayne P. Kelley, Eve Marder, Cyrus P. Billimoria
Publikováno v:
Journal of Neurochemistry. 87:642-656
The crustacean stomatogastric ganglion (STG) is modulated by both locally released neuroactive compounds and circulating hormones. This study presents mass spectrometric characterization of the complement of peptide hormones present in one of the maj
Publikováno v:
Journal of Neurochemistry. 82:1398-1405
Neuropeptides are a complex set of signaling molecules produced through enzymatic cleavages from longer prohormone sequences. The most common cleavage sites in prohormones are basic amino acid residues; however, processing is observed at non-basic si
Autor:
Zhixin J. Tan, Raju Subramanian, Jonathan V. Sweedler, Philip D. Floyd, Andrew G. Webb, Wayne P. Kelley
Publikováno v:
Analytical Chemistry. 71:5335-5339
An HPLC NMR system is presented that integrates a commercial microbore HPLC system using a 0.5-mm column with a 500-MHz proton NMR spectrometer using a custom NMR probe with an observe volume of 1.1 microL and a coil fill factor of 68%. Careful atten
Autor:
Alireza S. Kord, Philip D. Floyd, Frederick G. Vogt, Shiva G. Kapsi, Ping Hu, Shujun Chen, Mingjiang Sun, Wayne P. Kelley
Publikováno v:
Analytical chemistry. 84(10)
The characterization of orally-delivered peptide pharmaceuticals presents several challenges to analytical methods in comparison to characterization of conventional small-molecule drugs. These challenges include the analysis and characterization of d
Autor:
Wayne P. Kelley
Publikováno v:
Information Services & Use. 13:41-45
L'auteur adressent quelques questions cles, en tant que representant du GPO (Government Printing Office) concernant la politique d'information gouvernementale dans le contexte de l'information electronique et de reduction des couts
Autor:
Wayne P. Kelley
Publikováno v:
Government Publications Review. 19:321-331
This interview of U.S. Superintendent of Documents Wayne P. Kelley, Jr. was conducted on 25 January 1992 in San Antonio, Texas. Kelley discussed the Government Printing Office's plans for future production and distribution of governmental information