Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Wayne P, Bocchinfuso"'
Autor:
Lysiane Huber, David Anthony Barda, Youyan Zhang, Sheng-Bin Peng, Xueqian Gong, Junpeng Xiao, Deqi Guo, Jing Wang, Carmen Curtis, Bradley L. Ackermann, Wayne P. Bocchinfuso, Danalyn Manglicmot, Gregory P. Donoho, Paul D. Cornwell, Ryan J. Linder, Chong Si, Lee J. Burns, Michael J. Chalmers, Xi Lin, Denis J. McCann, Henry James Robert, Robert D. Van Horn, Serge Louis Boulet, Melbert-Brian D. Saflor, John Strelow, Lian Zhou
Publikováno v:
Cancer Research. 81:1259-1259
KRAS-G12C is an important oncogenic mutation in patients with NSCLC, CRC, and other cancer types. Currently, there are no FDA-approved KRAS-G12C inhibitors, and those in clinical development have relatively modest activity compared to other approved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce68cd8e784c9bdd29a2ff903f16c1b8
https://doi.org/10.1158/1538-7445.am2021-1259
https://doi.org/10.1158/1538-7445.am2021-1259
Autor:
Amy L. Cox, Eyas Raddad, Timothy M. Jones, Charles Reidy, Michaël Genin, John R. Stille, Chahrzad Montrose-Rafizadeh, Wayne P. Bocchinfuso, Laura F. Michael, Ellen A. Cannady, Manninen Peter Rudolph, M. Dodson Michael, Javier Agejas Francisco, Ana B. Bueno
Publikováno v:
Journal of Medicinal Chemistry. 58:9768-9772
The farnesoid X receptor (FXR) is a member of the "metabolic" subfamily of nuclear receptors. Several FXR agonists have been reported in the literature to have profound effects on plasma lipids in animal models. To discover novel and effective therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5fdc8964a35fa86c008ce8c81d6458
https://doi.org/10.1021/acs.jmedchem.5b01161
https://doi.org/10.1021/acs.jmedchem.5b01161
Autor:
Steven Kennedy, Dalia Barsyte-Lovejoy, Zahid Quyoom Bonday, Ken Weichert, Wayne P. Bocchinfuso, Grogan Michael John, Mary M. Mader, Masoud Vedadi, Robert M. Campbell, Cheryl H. Arrowsmith, Cortez Guillermo S, Fengling Li, Stephen Antonysamy, Mohammad S. Eram, Ernesto Guccione, Binghui Li, Peter Brown, Magdalena M. Szewczyk
Publikováno v:
ACS medicinal chemistry letters. 9(7)
[Image: see text] Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the formation of symmetric dimethylarginine in a number of nuclear and cytoplasmic proteins. Although the cellular functions of PRMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9105a4ed562b658e23a268ba5f567e5
https://pubmed.ncbi.nlm.nih.gov/30034588
https://pubmed.ncbi.nlm.nih.gov/30034588
Autor:
Keith R. Stayrook, Michael J. Chalmers, Patrick R. Griffin, Matthew W. Carson, Karol D. Holifield, Jeffery A. Dodge, Jun Zhang, Thierry Masquelin, Wayne P. Bocchinfuso, Ryan Edward Stites
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3459-3463
Modulation of the vitamin D receptor (VDR) with a ligand has the potential to be useful for the oral treatment of osteoporosis. One component of our lead generation strategy to identify synthetic ligands for VDR included a fragment based drug design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1c6af7a31beb3c7310ff5120af26a5
https://doi.org/10.1016/j.bmcl.2014.05.070
https://doi.org/10.1016/j.bmcl.2014.05.070
Autor:
Wayne P. Bocchinfuso, Leah M. Helvering, Timothy P. Spicer, Monica A. Istrate, Peter Hodder, Jerrold A. Bernard, Yan Wang, Chahrzad Montrose-Rafizadeh, Naresh Kumar, Patrick R. Griffin, Timothy Ivo Richardson, Jeffrey Alan Dodge, Richard W. Zink
Publikováno v:
SLAS Discovery. 16:183-191
The retinoid acid receptor-related orphan receptors (RORs) represent important targets for the treatment of metabolic and immune disorders. Here the authors describe the application of AlphaScreen(®) technology to develop a high-throughput screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c3f60d6fe73b980a84b7e778c2b283
https://doi.org/10.1177/1087057110389040
https://doi.org/10.1177/1087057110389040
Autor:
Wayne P. Bocchinfuso, Yuebai Li, Richard J. Santen, Nan Zhang, Mark R. Conaway, Hongkun Wang, Wei Yue, Kenneth S. Korach, Ji-Ping Wang, Ping Fan, Guijian Liu
Publikováno v:
International Journal of Cancer. 127:1748-1757
Development of breast cancer involves genetic factors as well as lifetime exposure to estrogen. The precise molecular mechanisms whereby estrogens influence breast tumor formation are poorly understood. While estrogen receptor alpha (ERalpha) is cert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8b825da1a3b1c357c344af94f5a7c8
https://doi.org/10.1002/ijc.25207
https://doi.org/10.1002/ijc.25207
Autor:
Wei Yue, Ji-Ping Wang, Yuebai Li, Wayne P. Bocchinfuso, Kenneth S. Korach, Prabu D. Devanesan, Eleanor Rogan, Ercole Cavalieri, Richard J. Santen
Publikováno v:
Clinical Cancer Research. 11:925s-930s
Long-term exposure to estradiol is associated with an increased risk of breast cancer, but the mechanisms responsible are not firmly established. The prevailing theory postulates that estrogens increase the rate of cell proliferation by stimulating e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af3dbc2d11103af5c2122234c4391ca4
https://doi.org/10.1158/1078-0432.925s.11.2
https://doi.org/10.1158/1078-0432.925s.11.2
Autor:
Ercole Cavalieri, J.-P Wang, Michael F. Verderame, Eleanor G. Rogan, Rosa Todorovic, Richard J. Santen, Y Li, Wei Yue, Wayne P. Bocchinfuso, Kenneth S. Korach, Prabu Devanesan
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 86:477-486
Long term exposure to estradiol increases the risk of breast cancer in a variety of animal species, as well as in women. The mechanisms responsible for this effect have not been firmly established. The prevailing theory proposes that estrogens increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86a6c13afb2ec65f2a1a2a0c65b908a
https://doi.org/10.1016/s0960-0760(03)00377-7
https://doi.org/10.1016/s0960-0760(03)00377-7
Autor:
Ralph L. Cooper, James A. Clark, Kenneth S. Korach, Wayne P. Bocchinfuso, Jonathan Lindzey, Page Myers, Sylvia C. Hewitt
Publikováno v:
Endocrinology. 141:2982-2994
Mammary glands from the estrogen receptor-a knockout (alphaERKO) mouse do not undergo ductal morphogenesis or alveolar development. Disrupted ERalpha signaling may result in reduced estrogen-responsive gene products in the mammary gland or reduced ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee517a02c8a1f6344a6164058dbeb640
https://doi.org/10.1210/endo.141.8.7609
https://doi.org/10.1210/endo.141.8.7609
Autor:
Kevin W. Gaido, Linda S. Leonard, John D. Norris, Stephen Safe, Ichen Chen, Kavita Ramamoorthy, Donald P. McDonnell, Wayne P. Bocchinfuso, Kenneth S. Korach, Fan Wang
Publikováno v:
Endocrinology. 138:1520-1527
The estrogenic activity of dieldrin, toxaphene, and an equimolar mixture of both compounds (dieldrin/toxaphene) was investigated in the 21-day-old B6C3F1 mouse uterus, MCF-7 human breast cancer cells, and in yeast-based reporter gene assays. Treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce0ad89fbaf9720b09faf8ec0d09a32
https://doi.org/10.1210/endo.138.4.5056
https://doi.org/10.1210/endo.138.4.5056