Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Wayne O, Hemphill"'
Autor:
Stephanie Batalis, LeAnn C. Rogers, Wayne O. Hemphill, Christopher H. Mauney, David A. Ornelles, Thomas Hollis
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
SAMHD1 activity is regulated by a network of mechanisms including phosphorylation, oxidation, oligomerization, and others. Significant questions remain about the effects of phosphorylation on SAMHD1 function and activity. We investigated the effects
Externí odkaz:
https://doaj.org/article/fd22dab9fa0f4b24a6f31374dd0f7ad9
Autor:
Wayne O. Hemphill, Sean R. Simpson, Mingyong Liu, Freddie R. Salsbury, Thomas Hollis, Jason M. Grayson, Fred W. Perrino
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mutations in the TREX1 3’ → 5’ exonuclease are associated with a spectrum of autoimmune disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS-STING DNA-sensing pathway signaling a type-I interferon (IFN) response that
Externí odkaz:
https://doaj.org/article/6b112cac40a84ca48d20a8c220831359
Autor:
Stephen L. Rego, Scott Harvey, Sean R. Simpson, Wayne O. Hemphill, Zachariah A. McIver, Jason M. Grayson, Fred W. Perrino
Publikováno v:
Autoimmunity, Vol 51, Iss 7, Pp 333-344 (2018)
Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (T
Externí odkaz:
https://doaj.org/article/06dec58f951b405fb83abbad7386c8f4
Publikováno v:
bioRxiv
The histone methyltransferase PRC2 (Polycomb Repressive Complex 2) silences genes via successively attaching three methyl groups to lysine 27 of histone H3. PRC2 associates with numerous pre-mRNA and lncRNA transcripts with a binding preference for G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fc6bb21b5f9cd83ab219635152d49e
https://doi.org/10.1101/2023.02.06.527314
https://doi.org/10.1101/2023.02.06.527314
The chromatin-modifying enzyme, Polycomb Repressive Complex 2 (PRC2), deposits the H3K27me3 epigenetic mark to negatively regulate expression at numerous target genes, and this activity has been implicated in embryonic development, cell differentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a8ad1954088e938fcf4f203558b5b08
https://doi.org/10.1101/2022.11.30.518601
https://doi.org/10.1101/2022.11.30.518601
We previously demonstrated that the PRC2 chromatin-modifying enzyme exhibits the ability to directly transfer between RNA and DNA without a free-enzyme intermediate state. Simulations suggested that such a direct transfer mechanism may be generally n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5724dd98701108da829c9d70f424b2e
https://doi.org/10.1101/2022.11.30.518605
https://doi.org/10.1101/2022.11.30.518605
Autor:
Giulia Amico, Wayne O Hemphill, Mariasavina Severino, Claudio Moratti, Rosario Pascarella, Marta Bertamino, Flavia Napoli, Stefano Volpi, Francesca Rosamilia, Sara Signa, Fred W Perrino, Marialuisa Zedde, Isabella Ceccherini
The TREX1 exonuclease degrades DNA to prevent aberrant nucleic acid sensing through the cGAS-STING pathway, and dominant Aicardi-Goutières Syndrome type 1 (AGS1) represents one of numerous TREX1-related autoimmune diseases. Monoallelic TREX1 mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830c496f6e08c07273f13b133de89afc
https://doi.org/10.20944/preprints202206.0372.v1
https://doi.org/10.20944/preprints202206.0372.v1
Autor:
Giulia, Amico, Wayne O, Hemphill, Mariasavina, Severino, Claudio, Moratti, Rosario, Pascarella, Marta, Bertamino, Flavia, Napoli, Stefano, Volpi, Francesca, Rosamilia, Sara, Signa, Fred, Perrino, Marialuisa, Zedde, Isabella, Ceccherini, On Behalf Of The Gaslini Stroke Study Group
Publikováno v:
Genes. 13(7)
The TREX1 exonuclease degrades DNA to prevent aberrant nucleic-acid sensing through the cGAS-STING pathway, and dominant Aicardi-Goutières Syndrome type 1 (AGS1) represents one of numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5617257f31e389bc1bb970de295f1fa7
https://pubmed.ncbi.nlm.nih.gov/35885962
https://pubmed.ncbi.nlm.nih.gov/35885962
The 3’ → 5’ exonuclease TREX1 functions in vivo to degrade DNA and prevent chronic immune activation through the cGAS-STING pathway. TREX1 has been described as a nonprocessive enzyme with little preference for ss-versus dsDNA, raising question
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48127256ac396cb64af2fbe70679aa4
https://doi.org/10.1101/2022.02.25.481063
https://doi.org/10.1101/2022.02.25.481063
Autor:
LeAnn C. Rogers, Stephanie Batalis, Christopher H. Mauney, David A. Ornelles, Wayne O. Hemphill, Thomas Hollis
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
SAMHD1 activity is regulated by a network of mechanisms including phosphorylation, oxidation, oligomerization, and others. Significant questions remain about the effects of phosphorylation on SAMHD1 function and activity. We investigated the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef43ba17efae57d29d59204f29e8cdfb
https://www.frontiersin.org/articles/10.3389/fmolb.2021.724870/full
https://www.frontiersin.org/articles/10.3389/fmolb.2021.724870/full