Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Wayne Lilyestrom"'
Autor:
Kai Zheng, Diya Ren, Y. John Wang, Wayne Lilyestrom, Thomas Scherer, Justin K. Y. Hong, Junyan A. Ji
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3952 (2021)
Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact product efficacy and patient safety. In this work, we used 2,2′-azobis (2-amidinopropane)
Externí odkaz:
https://doaj.org/article/e4a9f9583ec54a609836950196e707ce
Autor:
Junyan A Ji, Y John Wang, Kai Zheng, Justin K Y Hong, Diya Ren, Wayne Lilyestrom, Thomas M. Scherer
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3952, p 3952 (2021)
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3952, p 3952 (2021)
Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact product efficacy and patient safety. In this work, we used 2,2′-azobis (2-amidinopropane)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d2d69f2f72850333e44c5e3c419abd
https://pubmed.ncbi.nlm.nih.gov/33921206
https://pubmed.ncbi.nlm.nih.gov/33921206
Publikováno v:
The Journal of Physical Chemistry B. 122:2138-2154
The question of how nonspecific reversible intermolecular protein interactions affect solution rheology at high concentrations is fundamentally rooted in the translation of nanometer-scale interactions into macroscopic properties. Well-defined soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9dcd64869154982ee213f4bc389bf4
https://doi.org/10.1021/acs.jpcb.7b10728
https://doi.org/10.1021/acs.jpcb.7b10728
Publikováno v:
The Journal of Physical Chemistry B. 116:9611-9618
Small-angle X-ray scattering experiments of two monoclonal antibodies (mAbs) were performed as a function of Hofmeister salt type and concentration including 100 mM Na(2)SO(4), 100-600 mM of NaSCN, or 100-600 mM arginine chloride at pH 6.0 to yield i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d4e476e0bccd37e9aa18bbdbaf859d
https://doi.org/10.1021/jp303839t
https://doi.org/10.1021/jp303839t
Autor:
Thomas M. Scherer, Boyan Zhang, Liangyi Zhang, Charlene Li, Wayne Lilyestrom, Robert van Reis
Publikováno v:
Analytical Chemistry. 83:8501-8508
During purification process development and analytical characterization, a recombinant human monoclonal antibody, referred to as rmAb1, showed an anomalous charge heterogeneity profile by cation-exchange chromatography (CIEC), characterized by extrem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25d49f5f03bfa1c73d499238d20f7d5
https://doi.org/10.1021/ac2016129
https://doi.org/10.1021/ac2016129
Publikováno v:
Journal of Molecular Biology. 395:983-994
The enzyme poly(ADP-ribose) polymerase-1 (PARP-1) is a global monitor of chromatin structure and DNA damage repair. PARP-1 binds to nucleosomes and poly(ADP-ribosylates) histones and several chromatin-associated factors to expose specific DNA sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de445821f6e9b1d40d1a71a73b1618a0
https://doi.org/10.1016/j.jmb.2009.11.062
https://doi.org/10.1016/j.jmb.2009.11.062
Autor:
Dawei Li, Gerda Szakonyi, Xiaojiang S. Chen, Rui Zhao, Dahai Gai, James A. DeCaprio, Andrzej Jochimiak, Ellen Fanning, Wayne Lilyestrom, Rongguang Zhang
Publikováno v:
Nature. 423:512-518
The oncoprotein large tumour antigen (LTag) is encoded by the DNA tumour virus simian virus 40. LTag transforms cells and induces tumours in animals by altering the functions of tumour suppressors (including pRB and p53) and other key cellular protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e8e5a3c7b85226f01d6004cf349e93
https://doi.org/10.1038/nature01691
https://doi.org/10.1038/nature01691
Autor:
Shinya Watanabe, Jeffrey C. Hansen, Nicholas J. Clark, Michael G. Resch, Karolin Luger, Craig L. Peterson, Wayne Lilyestrom
The post-translational modification of histones is a key mechanism for the modulation of DNA accessibility. Acetylated lysine 56 in histone H3 is associated with nucleosome assembly during replication and DNA repair, and is thus likely to predominate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e137db0a5e4d2fd0491e90ab883cd64d
https://europepmc.org/articles/PMC2885283/
https://europepmc.org/articles/PMC2885283/
Publikováno v:
Genesdevelopment. 20(17)
The transformation potential of Simian Virus 40 depends on the activities of large T-antigen (LTag), which interacts with several cellular tumor suppressors including the important “guardian” of the genome, p53. Inhibition of p53 function by LTag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49399190e3f73ec4fbdabf1155fcbbb
https://pubmed.ncbi.nlm.nih.gov/16951249
https://pubmed.ncbi.nlm.nih.gov/16951249
Autor:
Ellen Fanning, Dawei Li, Gerda Szakonyi, Wayne Lilyestrom, Rongguang Zhang, Andrzej Joachimiak, Dahai Gai, James A. DeCaprio, Rui Zhao, Xiaojiang S. Chen
Publikováno v:
Nature. 425:102-102
Nature 423, 512–518 (2003). The name of A. J. was misspelt in the author list and should be Andrzej Joachimiak. Also, he is in the Biosciences Division of SBC (and not at the Advanced Photon Source, as published).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01a7b24d7938b586485554bd8a3c347c
https://doi.org/10.1038/nature01896
https://doi.org/10.1038/nature01896