Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Wayne Levin"'
Autor:
Linda M. Reik, Debra Lucas-McGady, Chao-Min Liu, Kuo-Sen Huang, John Lawson Roberts, Janna Holmgren, Wayne Levin
Publikováno v:
Analytical Biochemistry. 333:389-398
Heparanase plays an important role in the degradation of the extracellular matrix. It is implicated in inflammation, tumor angiogenesis and metastasis. We have developed two high-throughput methods for measuring heparanase activity and screening pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063eabf4138b877e89aabd5ea3e40a0d
https://doi.org/10.1016/j.ab.2004.06.023
https://doi.org/10.1016/j.ab.2004.06.023
Publikováno v:
BMB Reports. 36:421-425
The serine/threonine protein kinase family is a large and diverse group of enzymes that are involved in the regulation of multiple cellular pathways. Elevated kinase activity has been implicated in many diseases and frequently targeted for the develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872024c781ce453d84bbb04f0d17a211
https://doi.org/10.5483/bmbrep.2003.36.4.421
https://doi.org/10.5483/bmbrep.2003.36.4.421
Autor:
Kurt Hollfelder, Charles Belunis, Robert Crowther, Pete William Dunten, David J. Weber, Ursula Kammlott, Wayne Levin, Hanspeter Michel, Gwendolyn Ramsey, Amy Swain, Stanley Wertheimer
Publikováno v:
Journal of Molecular Biology. 316:257-264
We report crystal structures of the human enzyme phosphoenolpyruvate carboxykinase (PEPCK) with and without bound substrates. These structures are the first to be determined for a GTP-dependent PEPCK, and provide the first view of a novel GTP-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36444f143990f5f5c3214390f6d95e6
https://doi.org/10.1006/jmbi.2001.5364
https://doi.org/10.1006/jmbi.2001.5364
Publikováno v:
Journal of Hematotherapy. 4:389-394
The heterodimer-forming leucine zippers Fos and Jun can efficiently mediate the formation of bispecific F(ab')2 when they are fused separately to two different Fab' fragments. This recombinant method can be used in conjunction with the humanization p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c95d9da2466193f7db4d6dd7202326
https://doi.org/10.1089/scd.1.1995.4.389
https://doi.org/10.1089/scd.1.1995.4.389
Autor:
Dene E. Ryan, Vincent S. Madison, Grace Ju, Gordon Powers, Kathleen M. Lombard-Gillooly, Kim W. McIntyre, Wayne Levin, Tracey A. Varnell, Scott A. Greenfeder, David J. Shuster
Publikováno v:
Journal of Biological Chemistry. 270:22460-22466
We showed previously that replacement of Lys-145 in the IL-1 receptor antagonist (IL-1ra) with Asp resulted in an analog (IL-1ra K145D) with partial agonist activity. To identify additional amino acids that affect IL-1 bioactivity, we created second
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d679da6b87d01a21a0de4fe554d2ae04
https://doi.org/10.1074/jbc.270.38.22460
https://doi.org/10.1074/jbc.270.38.22460
Publikováno v:
Chemico-Biological Interactions. 95:57-77
The active site of cytochrome P450 1A1 has been probed with the substrate 7,8-dihydrobenzo[a]pyrene using a purified, reconstituted system composed of cytochrome P450 1A1, NADPH-cytochrome c reductase and lipid in the presence or absence of epoxide h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9967f32d672f95579fb0705201d448
https://doi.org/10.1016/0009-2797(94)03354-4
https://doi.org/10.1016/0009-2797(94)03354-4
Autor:
Michael C. MacLeod, Wayne Levin, Donald M. Jerina, Roland E. Lehr, James K. Selkirk, Allan H. Conney, Betty K. Mansfield
Publikováno v:
Carcinogenesis. 1(2)
Metabolites of benzo(e)pyrene (B[e]P) formed upon incubation of [3H]-B[e]P with hepatic microsomes from control and induced rats have been separated by high-pressure liquid chromatography and identified by comparison of retention times, absorbance an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558e6317d59c10466afcacf77ea2f3b5
https://pubmed.ncbi.nlm.nih.gov/22282997
https://pubmed.ncbi.nlm.nih.gov/22282997
Autor:
Douglas W. Morgan, Wayne Levin, Keren I. Hulkower, David L. DeWitt, Ting Chen, John W. Coffey, Stanley Wertheimer, William C. Hope, Robert M. Crowl, Celia M. Anderson
Publikováno v:
Arthritis & Rheumatism. 37:653-661
Objective In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f61ff21d2e8971ce4a3737c392625d7
https://doi.org/10.1002/art.1780370508
https://doi.org/10.1002/art.1780370508
Autor:
M. Kelley, R. Daniel, Wayne Levin, S. A. Mccluskey, Jayyosi Zaid, Dene E. Ryan, Paul E. Thomas, S. Bandiera, Linda M. Reik, Kathryn O. Cooper
Publikováno v:
Archives of Biochemistry and Biophysics. 301:345-354
Monoclonal antibodies have been successfully isolated which are isozyme-specific for cytochrome P450p (3A1) or P450l (3A2), two members of the steroid-inducible cytochrome P450 subfamily exhibiting 89% amino acid sequence homology, and these antibodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f1f7fb651849b91a760d2f73fa1ddc
https://doi.org/10.1006/abbi.1993.1154
https://doi.org/10.1006/abbi.1993.1154
Autor:
Frank John Podlaski, Jeffrey D. Hulmes, Richard Anthony Chizzonite, Waleed Danho, Venkata B. Nanduri, Alvin S. Stern, Maurice K. Gately, Wayne Levin, Yu-Ching E. Pan
Publikováno v:
Archives of Biochemistry and Biophysics. 294:230-237
Interleukin 12 (IL-12), formerly known as cytotoxic lymphocyte maturation factor and natural killer cell stimulatory factor, is a cytokine secreted by a human B lymphoblastoid (NC-37) cell line when induced in culture with phorbol ester and calcium i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4249554801449c662ff20389f4efda9b
https://doi.org/10.1016/0003-9861(92)90162-p
https://doi.org/10.1016/0003-9861(92)90162-p