Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Wayne L. Cody"'
Publikováno v:
The Melanotropic Peptides ISBN: 9781351074384
The Melanotropic Peptides
The Melanotropic Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdae2518f1665f7ef0f6dc892ddda3b5
https://doi.org/10.1201/9781351074384-7
https://doi.org/10.1201/9781351074384-7
Publikováno v:
The Melanotropic Peptides ISBN: 9781351074384
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20543c02f95e312aa2c48b28f6ece152
https://doi.org/10.1201/9781351074384-6
https://doi.org/10.1201/9781351074384-6
Autor:
Robert P. Schaum, Lakshmi Narasimhan, Agustin Casimiro-Garcia, Chad A. Van Huis, Danette Dudley, Kevin J. Filipski, Wayne L. Cody, Christopher F. Bigge, Michael Pamment, Jeremy J. Edmunds, Thomas B. McClanahan, Ronald J. Heemstra, Vaishali Sahasrabudhe, Robert J. Leadley, Igor Mochalkin, J. Thomas Peterson, Jeffrey T. Kohrt
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:2501-2511
Aiming to improve upon previously disclosed Factor Xa inhibitors, a series of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides were explored with the intent of increasing the projected human half-life versus 5 (projected human t1/2 = 6 h). A stereosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af03cee3f28d5026f6997846a715ea19
https://doi.org/10.1016/j.bmc.2009.01.063
https://doi.org/10.1016/j.bmc.2009.01.063
Autor:
M. Lebl, Wayne L. Cody, Ana Maria de Lauro Castrucci, M. E. Hadley, Brian C. Wilkes, Victor J. Hruby
Publikováno v:
International Journal of Peptide and Protein Research. 24:472-479
The highly potent cyclic analogue of alpha-MSH, Ac-[Cys4,Cys10]-alpha-MSH4-13-NH2, was structurally modified in position 4. Four analogues were prepared and their biological activities in the in vitro frog and lizard skin bioassays were determined. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f16ef3a0176949759123ef0940407cf0
https://doi.org/10.1111/j.1399-3011.1984.tb03147.x
https://doi.org/10.1111/j.1399-3011.1984.tb03147.x
Publikováno v:
International Journal of Peptide and Protein Research. 27:685-694
Several alpha-melanotropin (alpha-MSH) analogues with para substituted aromatic and nonaromatic amino acids in the 7-position of the hormone were prepared and their melanotropic activities determined in the frog (Rana pipiens) and lizard (Anolis caro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87cbd2150a68ec16cdcfff4a54d082ab
https://doi.org/10.1111/j.1399-3011.1986.tb01066.x
https://doi.org/10.1111/j.1399-3011.1986.tb01066.x
Autor:
Christopher F. Bigge, Robert P. Schaum, Kathleen M. Welch, John W. Bryant, Chad A. Van Huis, Tawny K. Dahring, Vaisheli Sahasrabudhe, Ron Heemstra, Liguo Chi, Thomas B. McClanahan, Jeremy J. Edmunds, Jeffrey T. Kohrt, Staci Haarer, Erli Zhang, Robert J. Leadley, Wayne L. Cody, Lakshmi Narasimhan, Kevin J. Filipski, Agustin Casimiro-Garcia, Danette Dudley, Nancy Janiczek, J. Thomas Peterson
Publikováno v:
Chemical Biology & Drug Design. 70:100-112
Herein, we report the discovery of novel, proline-based factor Xa inhibitors containing a neutral P1 chlorophenyl pharmacophore. Through the additional incorporation of 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one 22, as a P4 pharmacophore, we discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66a75bf8555ab9fd1f915bffc19bd94
https://doi.org/10.1111/j.1747-0285.2007.00539.x
https://doi.org/10.1111/j.1747-0285.2007.00539.x
Autor:
Wayne L. Cody, Staci Haarer, Erli Zhang, Chad A. Van Huis, Christopher F. Bigge, Lakshmi Narasimhan, Robert P. Schaum, John W. Bryant, Agustin Casimiro-Garcia, Thomas B. McClanahan, Danette Dudley, Kevin J. Filipski, Robert J. Leadley, Kathleen M. Welch, Jeremy J. Edmunds, Ronald J. Heemstra, Nancy Janiczek, Jeffrey T. Kohrt, J. Thomas Peterson
Publikováno v:
Chemical Biology & Drug Design. 69:444-450
A novel series of pyrrolidine-1,2-dicarboxamides was discovered as factor Xa inhibitors using structure-based drug design. This series consisted of a neutral 4-chlorophenylurea P1, a biphenylsulfonamide P4 and a D-proline scaffold (1, IC(50) = 18 nM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f9136431b3dc2f879186d19debb428
https://doi.org/10.1111/j.1747-0285.2007.00520.x
https://doi.org/10.1111/j.1747-0285.2007.00520.x
Autor:
Shrilakshmi Desiraju, Mohamad-Rami Jaber, Jeffrey T. Kohrt, Jeremy J. Edmunds, Christopher F. Bigge, Shaoyi Sun, Chad A. Van Huis, Wayne L. Cody, Agustin Casimiro-Garcia, Danette Dudley, Samarendra N. Maiti, Kevin J. Filipski
Publikováno v:
Tetrahedron Letters. 47:7677-7680
A robust method has been developed to couple a wide variety of pyridin-2-ones and aryl halides. This C–N bond forming reaction makes use of catalytic copper(I) iodide and the ligand 8-hydroxyquinoline. These conditions tolerate a wide degree of fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c40ebd7886fd8f4dc8e6f3f995ddb718
https://doi.org/10.1016/j.tetlet.2006.08.112
https://doi.org/10.1016/j.tetlet.2006.08.112
Autor:
Chad A. Van Huis, Jeremy J. Edmunds, Kenneth J. Shaw, Marc Whitlow, Arnaiz Damian O, Marc Adler, Cuiman Cai, David R. Light, Kamlai Saiya-Cork, J. Adam Willardsen, Lakshmi Narasimhan, Erli Zhang, Stephen T. Rapundalo, Kevin J. Filipski, Wayne L. Cody, Kirk Mclean, Danette Dudley, Jeffrey T. Kohrt, Cecile McKnight, Robert J. Leadley, Yuo-Ling Chou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4752-4756
The activated Factor VII/tissue factor complex (FVIIa/TF) plays a key role in the formation of blood clots. Inhibition of this complex may lead to new antithrombotic drugs. An X-ray crystal structure of a fluoropyridine-based FVIIa/TF inhibitor bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2c6b0dc75cebe92a561353096bd522
https://doi.org/10.1016/j.bmcl.2005.07.059
https://doi.org/10.1016/j.bmcl.2005.07.059
Autor:
Noel A. Powell, Robert Ostroski, Cuiman Cai, Mehran Jalaie, Dennis Michael Downing, Daniel D. Holsworth, Wayne L. Cody, John W. Bryant, J. Michael Ryan, Jeremy J. Edmunds
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:2657-2664
Ketopiperazine 2 was designed from a previously published analog. Compound 2 was shown to be a novel, potent inhibitor of renin that, when administered orally, lowered blood pressure in a hypertensive double transgenic (human renin and angiotensinoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cb88e0704d1423b0de77414b8dbac1
https://doi.org/10.1016/j.bmc.2005.01.048
https://doi.org/10.1016/j.bmc.2005.01.048