Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Wayne L. Chandler"'
Publikováno v:
Case Reports in Medicine, Vol 2009 (2009)
The primary function of recombinant activated factor VII (rFVIIa) is to increase thrombin formation which leads to increased fibrin and less “bleeding.” As a result, most of literature utilizes “bleeding” as the outcome measure with respect t
Externí odkaz:
https://doaj.org/article/a843024508484618b1f6869a5796a20b
Publikováno v:
Transfusion. 63:933-941
Autor:
Rida A Hasan, Jennifer Pak, Christa Jefferis Kirk, Joshua M Friedland-Little, Wayne L Chandler
Publikováno v:
American Journal of Clinical Pathology. 159:60-68
Objectives Activated partial thromboplastin time (aPTT) is the primary test used to monitor intravenous (IV) direct thrombin inhibitors (DTIs) but has many limitations. The plasma diluted thrombin time (dTT) has shown better correlation with DTI leve
Autor:
Wayne L, Chandler
Publikováno v:
Thrombosis Research. 211:154-160
Extracorporeal membrane oxygenation (ECMO) can be life-saving, but suffers from thrombus formation in the circuit with associated risks of oxygenator occlusion, hemolysis and arterial embolism. The formation of thrombin is the key step to thrombus fo
Publikováno v:
ASAIO Journal. 68:1083-1092
Thrombosis in extracorporeal membrane oxygenation (ECMO) circuits remains a frequent complication. We characterize the location, extent, structure, and clinical implications of thrombi in 53 ECMO circuits from 46 pediatric patients. The tubing, pump,
Autor:
Oksana Volod, Andrew J. Goodwin, Dong Chen, Huy P. Pham, James Alexander Isom, Karen A. Moser, John D. Olson, Russell A. Higgins, Amanda M. VanSandt, Kristi J. Smock, Geoffrey D. Wool, Thomas A. Long, Marian A. Rollins-Raval, Neil S Harris, Wayne L. Chandler
Publikováno v:
Archives of Pathology & Laboratory Medicine. 146:145-153
Context.— Assessing direct oral anticoagulant (DOAC) drug levels by reliable laboratory assays is necessary in a number of clinical scenarios. Objective.— To evaluate the performance of DOAC-specific assays for various concentrations of dabigatra
Publikováno v:
Artificial organsREFERENCES. 47(1)
Most pediatric patients show a decline in platelet counts while on extracorporeal life support (ECLS) and require multiple platelet transfusions. To better understand platelet loss during ECLS, this study estimated platelet loss rates due to diagnost
Autor:
David Michael McMullan, Wayne L. Chandler, Dana C. Matthews, Thomas V. Brogan, Christopher R. Burke, Larissa Yalon, Nabiha Huq Saifee
Publikováno v:
ASAIO Journal. 66:230-237
To balance the risk of bleeding versus circuit thrombosis during extracorporeal life support (ECLS), it is important to monitor anticoagulants and hemostasis. We evaluated the prothrombin time (PT), partial thromboplastin time (PTT), activated clotti
Autor:
Russell A. Higgins, Wayne L. Chandler, Dong Chen, Oksana Volod, Kristi J. Smock, Karen A. Moser, Huy P. Pham, John D. Olson, Alan F. Brown
Publikováno v:
Archives of Pathology & Laboratory Medicine. 143:472-482
Context.—The College of American Pathologists (CAP) developed proficiency testing for platelet function assays by using blood collected by the participant added to challenge tubes containing either saline (normal) or tirofiban (abnormal).Objective.
Autor:
Jenna Khan, Wayne L. Chandler
Publikováno v:
American Journal of Clinical Pathology. 151:424-432
Objectives To determine the relationship between baseline variations in the partial thromboplastin time (PTT) and the discordance between the PTT and anti-Xa heparin activity (anti-Xa) during heparin therapy. Methods The baseline PTT on heparin was d