Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Wayne Klohs"'
Autor:
Franciele C. Kipper, Eva Rothenberger, Abigail Kelly, Michael Gillespie, Ahmed Attaya, Diane R. Bielenberg, Sui Huang, Lance Pflieger, Frank Sciavolino, Aaron Mathias, Wayne Klohs, John Parkinson, Gary Mathias, Dipak Panigrahy
Publikováno v:
Cancer Research. 83:1135-1135
Background: TP317 is a novel, highly stable chelate salt of resolvin E1 (RvE1), a pro-resolution mediator that stimulates myeloid cell phagocytosis of tumor debris and attenuates pro-tumoral inflammation through activation of the GPCR, ChemR23 (Sulci
Autor:
Wayne Klohs, Denise L. Driscoll, Aneesa M. Amar, Wilbur R. Leopold, H. D. Hollis Showalter, Brian G. Hartl, William L. Elliott, Bill J. Roberts, Stacey L. Boushelle, Andrew M. Thompson, Randall W. Steinkampf, Connolly Cleo, Patrick W. Vincent, William A. Denny, James M. Hamby, Sandra J. Patmore, Alan J. Kraker
Publikováno v:
Journal of Medicinal Chemistry. 43:4200-4211
A series of 3-aryl-1,6-naphthyridine-2,7-diamines and related 2-ureas were prepared and evaluated as inhibitors of the FGF receptor-1 tyrosine kinase. Condensation of 4,6-diaminonicotinaldehyde and substituted phenylacetonitriles gave intermediate na