Výsledky vyhledávání - "Wayne K. Duholke"

Structural characterization of a degradation product of tin ethyl etiopurpurin (SnET2): Comparison of the long-range heteronuclear correlations detected using conventional GHMBC and IMPEACH-MBC in conjunction with submicro NMR probe technology

Autor: Kenneth Rosenqvist, Chad E. Hadden, Mako N. Masuno, Gary E. Martin, Thomas J. Thamann, Brian D. Kaluzny, Wayne K. Duholke, Phillip E. Sanders, Byron C. Robinson

Publikováno v: Journal of Heterocyclic Chemistry. 40:389-393

During the terminal heat sterilization of the lipid emulsion final dose formulation of the photodynamic therapeutic (PDT) agent tin ethyl etiopurpurin (SnET2), a new degradant was observed at very low levels. The degradant, which was prone to photo-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67f18e8282f148573bf48e9d94aba013
https://doi.org/10.1002/jhet.5570400233

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Identification of degradants of a complex alkaloid using NMR cryoprobe technology and ACD/structure elucidator

Autor: Bruce A. Stiemsma, Antony J. Williams, Eduard R. Martirosian, Thomas J. Thamann, Sergey G. Molodtsov, Gary E. Martin, David J. Russell, Brian D. Kaluzny, Paul L. Schiff, Chad E. Hadden, Ronald C. Crouch, Kirill A. Blinov, Mikhail E. Elyashberg, Jane E. Guido, Wayne K. Duholke

Publikováno v: Journal of Heterocyclic Chemistry. 39:1241-1250

Identification of degradants of pharmaceuticals is a necessary challenge of the drug development process following the subjection of candidate molecules to a variety of physico-chemical stresses. It would be desirable to be able to conduct such studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e3e43caa8b71528baa159a9d497e9d1
https://doi.org/10.1002/jhet.5570390619

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Characterization of a trace by-product of the synthesis of the protease inhibitor tipranavir (PNU-140690)

Autor: Thomas J. Thamann, Wayne K. Duholke, Brian D. Kaluzny, Russell H. Robins, Jane E. Guido, Bruce A. Pearlman, Frank W. Crow, Chad E. Hadden, Gary E. Martin

Publikováno v: Journal of Heterocyclic Chemistry. 36:1107-1114

TipranavirTM (PNU-140690) is a protease inhibitor under clinical investigation for the treatment of human acquired immunodeficiency syndrome (AIDS). During scale-up synthesis of clinical quantities of the bulk drug, a colored, transient by-product of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3a6cd94e9f57f059ddc9d5eaca9726d
https://doi.org/10.1002/jhet.5570360448

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Structural identification of a novel degradant of the antibiotic pirlimycin formed under thermal stress conditions

Autor: Constance G. Chidestere, James R. Blinn, John W. Hallberg, Anne M. Cooper, Wayne K. Duholke, Frank W. Crow, Richard F. Smith, Gary E. Martin, Thomas J. Thamann

Publikováno v: Journal of Heterocyclic Chemistry. 36:1049-1055

The structure of a novel, thermally-induced degradant of the antibiotic pirlimycin is presented. The degradant was discovered during thermal stress stability testing of pirlimycin. The structure was determined using high resolution mass spectrometry,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e16c336ad2575431f412f644f2102e84
https://doi.org/10.1002/jhet.5570360436

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Structural characterization of components of a mixture-characterization of a facile oxidation product of cryptolepinonein situ

Autor: Paul L. Schiff, Wayne K. Duholke, Russell H. Robins, Chad E. Hadden, Jane E. Guido, Gary E. Martin, Maged H. M. Sharaf

Publikováno v: Journal of Heterocyclic Chemistry. 36:525-531

The nmr analysis of a mixture of cryptolepinone and it's 5(N)-oxide in a 1.5:1 ratio is discussed. The differentiation of the resonances of the two similar compounds, and elucidation of the unknown 5(N)-oxide relied primarily on IDR-GHSQC-TOCSY data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::316fe60fffca8921cdf35070de4870b3
https://doi.org/10.1002/jhet.5570360232

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Complete spectroscopic structural characterization of novobiocin, isonovobiocin, decarbamylnovobiocin, 2″-(o-Carbamyl)novobiocin, and novobiocin-2″,3″-carbonate

Autor: Chad E. Hadden, Frank W. Crow, David A. Hahn, Richard F. Smith, Christopher S. Mallory, Kathleen A. Farley, Gary E. Martin, Thomas J. Thamann, Brian D. Kaluzny, Wayne K. Duholke

Publikováno v: Journal of Heterocyclic Chemistry. 36:365-370

The rigorous structural characterization of novobiocin, is reported using mass spectrometric, infrared and nmr spectroscopic analysis. Complete nmr assignments are reported. Previous reports in the literature had left some quaternary carbon resonance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d087b9699c459d4111e593965aca6978
https://doi.org/10.1002/jhet.5570360206

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Susceptibility of morpholine substituents to photo-oxidative decomposition-identification of photo-oxidative degradants of linezolid (PNU-100766)

Autor: Sims Sandra M, Brian E. Thompson, Thomas J. Thamann, Jane E. Guido, Tsutoma Tahara, Wayne K. Duholke, Yukimi Noro, Kathleen A. Farley, Brian D. Kaluzny, Russell H. Robins, Phil B. Bowman, Gary E. Martin, Toshihide Nishimura

Publikováno v: Journal of Heterocyclic Chemistry. 36:265-270

Parenteral formulations of linezolid (PNU-100766), a novel (S)-3-(4′-fluorophenyl)-5-N-acetamidomethyloxazolidin-2-one antibiotic, were subjected to photo-stability testing as required by ICH guidelines. Direct, reversed phase chromatographic evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72636ad3f1038ee421252fdf4acd3d23
https://doi.org/10.1002/jhet.5570360140

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Unequivocal location of sites ofN-oxidation using natural abundance long-range1H,15N GHNMQC two-dimensional NMR

Autor: Thomas J. Thamann, Jane E. Guido, Bowman Phil B, Kathleen A. Farley, Frank W. Crow, Brenda S. Vonderwell, Russell H. Robins, Gary E. Martin, Richard F. Smith, Wayne K. Duholke, Sandra M. Sims, Jay C. Brumfield

Publikováno v: Magnetic Resonance in Chemistry. 36:S11-S16

A method is described for unequivocally establishing the site of N-oxidation which relies on the relatively large downfield shift of aliphatic nitrogen resonances following oxidation. The technique described is based on 15N at natural abundance and d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a8d0303e95b2c4cf6a696d9e47ad091
https://doi.org/10.1002/(sici)1097-458x(199806)36:133.0.co

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