Zobrazeno 1 - 10 of 105 pro vyhledávání: '"Wayne K. Anderson"'
1
An Improved Synthesis of 5,7-Dimethoxy-4-methylphthalide, A Key Intermediate in the Synthesis of Mycophenolic Acid
Autor: Wayne K. Anderson, Gergely M. Makara, Kevin Klubek
Publikováno v: Synthetic Communications. 26:1935-1942
An efficient synthetic pathway is described for 5,7-dimethoxy-4-methylphthalide, a key intermediate in the synthesis of mycophenolic acid and its analogues. The procedure starts from methyl 3,5-dimethoxybenzoate and involves five simple steps to give
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2eea7413604af9d917ebaf271c9fa680
https://doi.org/10.1080/00397919608003548
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2
Nuclear Magnetic Resonance and Molecular Modeling Study on Mycophenolic Acid: Implications for Binding to Inosine Monophosphate Dehydrogenase
Autor: Gergely M. Makara, Wayne K. Anderson, György M. Keserü, Mária Kajtár-Peredy
Publikováno v: Journal of Medicinal Chemistry. 39:1236-1242
The conformation of the sodium salt of mycophenolic acid (MPA), a potent inhibitor of inosine monophosphate dehydrogenase (IMPD), derived from 1D DIFNOE and 2D ROESY experiments in water and molecular dynamics (MD) is described. The hexenoic acid sid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1220ae1f87a7ac78c1b2d131b454bc
https://doi.org/10.1021/jm950600m
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3
Synthesis and Modeling Studies with Monocyclic Analogues of Mycophenolic Acid
Autor: R. T. Swann, Gergely M. Makara, T. L. Boehm, Wayne K. Anderson
Publikováno v: Journal of Medicinal Chemistry. 39:46-55
Two stepwise procedures, developed for the introduction of the (E)-4-methyl-4-hexenoic acid side chain of mycophenolic acid, were used in the synthesis of monocyclic mycophenolic acid analogues 2a-i. The derivatives with a methyl group or hydrogen at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e1a77b572efae2c51c6bbabd1a33ce
https://doi.org/10.1021/jm9501339
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4
Facile Preparation of Substituted Allenic Estersviathe Ortho Ester Claisen Rearrangement
Autor: Gaifa Lai, Wayne K. Anderson
Publikováno v: Synthetic Communications. 25:4087-4091
Five substituted allenic esters were prepared in good yields through the ortho ester Claisen rearrangement of primary and secondary propargyl alcohols.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d206b3e7887aeea4f675ed3bc1c55038
https://doi.org/10.1080/00397919508011486
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6
Synthesis, antitumor activity, and chemical properties of silaplatin and related platinum(II) and platinum(IV) complexes derived from .beta.-silyl amines
Autor: Jacqueline Plowman, D. M. Houston, V. L. Narayanan, R. D. Haugwitz, Yueh-Sha Wang, Wayne K. Anderson, Ravindra Kasliwal
Publikováno v: Journal of Medicinal Chemistry. 38:3789-3797
Platinum (II) and platinum (IV) coordination complexes derived from beta-silyl-substituted amines were prepared. The solubility of selected complexes in water and physiological saline was measured, and the effect of the beta-silicon on the reactivity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343fd9f223510978e29e91e77a17b6ba
https://doi.org/10.1021/jm00019a008
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7
Polarization-insensitive metal-semiconductor-metal nanostructures for ultra-fast UV detectors
Autor: Suhua Jiang, Wayne K. Anderson, Qiaoqiang Gan, Chong Tong, Haifeng Hu, Xie Zeng, Jie Deng
Publikováno v: Frontiers in Optics 2012/Laser Science XXVIII.
Because the Fabry-Perot cavity modes supported by nanostructures on thin ZnO layers for TE and TM polarized incidence overlap with each other at UV wavelengths, a polarization-insensitive nano-interdigitated electrode is achievable for ultra-fast UV
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b6f5b6e258b2dfb60e8c9b26e119628
https://doi.org/10.1364/fio.2012.fth3d.6
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8
Oxidative Degradation of Castanospermine
Autor: Wayne K. Anderson, Pingzhong Tan
Publikováno v: Synthetic Communications. 24:3081-3089
Oxidation of castanospermine (1) (HIO4) and its 6-O-acetyl derivative 7 [Pb(OAc)4], followed by reduction and acetylation, were reported. A mechanism is proposed for the novel Pb(OAc)4 oxidation of a β-tertiary amino alcohol.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24ff6889410eb14e0d2a5d31a32653d6
https://doi.org/10.1080/00397919408011321
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9
Synthesis of 4-(2-chloroethyl)-2,3-dihydro[1,4]oxazino[2,3-b]quinoline and 4-(2-chloroethyl)2,3-dihydropyrido[2,3-b][1,4]oxazine
Autor: Deepak K. Dalvie, Wayne K. Anderson
Publikováno v: Journal of Heterocyclic Chemistry. 30:1533-1536
The title compounds were synthesized from 3-[bis(2-hydroxyethyl)- amino]quinolin-2(1H)-one (11a) and 3-[bis(2-hydroxyethyl)amino]- pyridin-2(1H)-one (18) respectively. The preparation involved a tandem chlorination/cyclization reaction
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e21ec23447df9ed6983c4883877d2b3
https://doi.org/10.1002/jhet.5570300614
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10
Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole
Autor: Patrick Van Roey, Wayne K. Anderson, Kinder Frederick Ray, J. M. Salerno, Mark A. Jarosinski, D. Michael Houston, Rao N. Kode
Publikováno v: Drug Development Research. 30:143-146
The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X-ray crystallography. The chemical reactivity, toxicity, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::284baa8d248400826ada0fb4e67a4ed0
https://doi.org/10.1002/ddr.430300306
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