Zobrazeno 1 - 10 of 50 pro vyhledávání: '"Wayne J, Thompson"'
1
STEREOCONTROLLED SYNTHESIS OF HIV-l PROTEASE INHIBITORS WITH C
Autor: Arun K, Ghosh, Sean P, McKee, Wayne J, Thompson
Publikováno v: Tetrahedron letters. 32(41)
An efficient and stereocontrolled synthesis of various C2-symmetric HIV-l protease inhibitors is described, starting from commercially available and inexpensive D-mannitol.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::feccc4055b99b53f44cb6d78f3b341e0
https://pubmed.ncbi.nlm.nih.gov/30310242
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2
N,N'-Disuccinimidyl Carbonate: A Useful Reagent for Alkoxycarbonylation of Amines
Autor: T. T. Duong, Wayne J. Thompson, S. P. Mckee, Arun K. Ghosh
Publikováno v: Tetrahedron letters. 33(20)
An efficient and mild method for alkoxycarbonylation of amines is described, utilizing commercially available N,N'-disuccinimidyl carbonate.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58930bba4f17c3aa55795398a18affcc
https://pubmed.ncbi.nlm.nih.gov/30310243
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3
Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic
Autor: S. P. Mckee, Joan C Zugay, Wayne J. Thompson, Arun K. Ghosh, Paul L. Darke
Publikováno v: The Journal of organic chemistry. 58(5)
The synthesis of a differentially protected dipeptide mimic 10 in enantiomerically pure form is described. The key step involves the epimerization of the C-2 center of the lactone 4, hydrolysis and protection of the resulting hydroxy acid, followed b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531e3c436274e4ad65c07b24556f3d8b
https://pubmed.ncbi.nlm.nih.gov/30310240
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4
Design and synthesis of N-alkylated saccharins as selective α-1a adrenergic receptor antagonists
Autor: Theodore P. Broten, Wayne J. Thompson, Hee Yoon Lee, Ann L. Scott, Jill M. Erb, Joel R. Huff, Terry W. Schorn, Jennie B. Nerenberg, Raymond S.L. Chang, Tsing B. Chen, James P. Guare, Stacey O'Malley, Peter M. Munson, Jeffrey M. Bergman
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:2467-2472
Benign prostatic hyperplasia can be managed pharmacologically with alpha-1 adrenergic receptor antagonists. Agents that demonstrate selectivity for the alpha-1a receptor subtype may offer advantages in clinical applications with respect to hypotensiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137e9f8d465460c0a6128622617a9ba7
https://doi.org/10.1016/s0960-894x(98)00446-6
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5
Cyclic sulfone-3-carboxamides as novel P2-ligands for Ro 31-8959 based HIV-1 protease inhibitors
Autor: Joel R. Huff, Wayne J. Thompson, Wenming Liu, Arun K. Ghosh, Peter M. Munson
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:83-88
Cyclic sulfone-3-carboxamides are effective P2-1igands for HIV-1 protease inhibitors. Incorporation of 3S-tetrahydro-2H-thiopyrancarboxamide-l, l-dioxide in the hydroxyethylamine series resulted in inhibitor 14 (IC50=9 nM, CIC95=200 nM) with improved
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf223bc42dae5573d4788ab4d31ea60
https://doi.org/10.1016/0960-894x(94)00463-p
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6
Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands
Autor: Arun K. Ghosh, Wayne J. Thompson, M. Katharine Holloway, Sean P. McKee, Tien T. Duong, Hee Yoon Lee, Peter M. Munson, Anthony M. Smith, Jenny M. Wai, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William A. Schleif, Joel R. Huff, Paul S. Anderson
Publikováno v: Journal of Medicinal Chemistry. 36:2300-2310
A series of protease inhibitors bearing constrained unnatural amino acids at the P2-position and novel heterocycles at the P3-position of compound 1 (Ro 31-8959) were synthesized, and their in vitro enzyme inhibitory and antiviral activities were eva
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80f18b7de8e6f8992758e7b259b292b
https://doi.org/10.1021/jm00068a006
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8
ChemInform Abstract: A Highly Enantioselective Synthesis of Phosphate Triesters
Autor: Kensaku Nakayama, Wayne J. Thompson
Publikováno v: ChemInform. 22
A general methodology for the preparation of both enantiomers of a variety of trialkyl phosphates with enantiomeric excesses ranging from 87 to 92% is described. Bis(2,4-dichlorophenyl) phosphoramidates bearing a 2-substituted pyrrolidine moiety as t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c69a1c94ae228374f2e169472bdd4e7
https://doi.org/10.1002/chin.199101269
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10
ChemInform Abstract: A Stereocontrolled Synthesis of trans-Allylic Amines
Autor: Thomas J. Tucker, John E. Schwering, Wayne J. Thompson, James L. Barnes
Publikováno v: ChemInform. 23
The palladium catalyzed coupling of allylic acetates with carbon nucleophiles generates urethane protected trans-allylic amines with exceptionally high stereoselectivity.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a98a624e3627d6eaf99c7f377c5f0486
https://doi.org/10.1002/chin.199208057
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