Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Wayne Harshbarger"'
Autor:
Wayne Harshbarger, Priyanka D. Abeyrathne, Sai Tian, Ying Huang, Sumana Chandramouli, Matthew James Bottomley, Enrico Malito
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infections resulting in medical intervention and hospitalizations during infancy and early childhood, and vaccination against RSV remains a public health prio
Externí odkaz:
https://doaj.org/article/ae7c2f6a21af45829645ba478d1f0316
Autor:
Wayne Harshbarger, Sai Tian, Newton Wahome, Ankita Balsaraf, Deep Bhattacharya, Desheng Jiang, Ratnesh Pandey, Kunal Tungare, Kristian Friedrich, Nurjahan Mehzabeen, Marco Biancucci, Diana Chinchilla-Olszar, Corey P Mallett, Ying Huang, Zihao Wang, Matthew James Bottomley, Enrico Malito, Sumana Chandramouli
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1008943 (2020)
Respiratory syncytial virus (RSV) is a global public health burden for which no licensed vaccine exists. To aid vaccine development via increased understanding of the protective antibody response to RSV prefusion glycoprotein F (PreF), we performed s
Externí odkaz:
https://doaj.org/article/98f5af6f2dbe4087aa5a737f65ccd637
Autor:
Jinhua Wang, Senthil Muthaswamy, Kevin M. Haigis, Rita Sulahian, Kenneth D. Westover, Emily J. Poulin, Ryoma Ohi, Sergio Espinosa, Shuning He, Taebo Sim, Lianbo Li, Miljan Kuljanin, Nathanael S. Gray, Yan Liu, Nam Doo Kim, Joseph D. Mancias, Ling Huang, Brian M. Wolpin, Charles Y. Lin, Andrew J. Aguirre, Srivatsan Raghavan, Nora Diéguez-Martínez, Radha L. Kalekar, Jost Vrabic Koren, Zeng Zhiyang, Fleur M. Ferguson, James D Vasta, Behnam Nabet, William C. Hahn, Raymond W.S. Ng, Cesear Corona, Wayne Harshbarger, Alan L. Leggett, Matthew B. Robers, A. Thomas Look, Jose M. Lizcano, Annan Yang
Publikováno v:
Nature chemical biology
Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in a wide range of cancers, including pancreatic ductal adenocarcinoma (PDAC). However, little is known about its potential as a therapeutic target. We used chemoproteom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0e3c79de5a15f9fac24f15a81dc963
https://doi.org/10.1038/s41589-020-0506-0
https://doi.org/10.1038/s41589-020-0506-0
Autor:
Ying Huang, Wayne Harshbarger, Enrico Malito, Matthew J. Bottomley, Sai Tian, Priyanka D Abeyrathne, Sumana Chandramouli
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infections resulting in medical intervention and hospitalizations during infancy and early childhood, and vaccination against RSV remains a public health prio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bfb230b32439cfcd54b272a3183c0a
https://doi.org/10.1080/19420862.2021.1955812
https://doi.org/10.1080/19420862.2021.1955812
Autor:
Nurjahan Mehzabeen, Matthew J. Bottomley, Sai Tian, Wayne Harshbarger, Diana Chinchilla-Olszar, Sumana Chandramouli, Zihao Wang, Marco Biancucci, Deep S. Bhattacharya, Kristian Friedrich, Ying Huang, Newton Muchugu Wahome, Desheng Jiang, Corey P. Mallett, Enrico Malito, Ratnesh Pandey, Ankita Balsaraf, Kunal Tungare
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 11, p e1008943 (2020)
PLoS Pathogens, Vol 16, Iss 11, p e1008943 (2020)
Respiratory syncytial virus (RSV) is a global public health burden for which no licensed vaccine exists. To aid vaccine development via increased understanding of the protective antibody response to RSV prefusion glycoprotein F (PreF), we performed s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0a9dd044a3e6e5eab6dde5c6cc8a36
http://europepmc.org/articles/PMC7660905
http://europepmc.org/articles/PMC7660905
Autor:
Nathanael S. Gray, Fleur M. Ferguson, Xianming Deng, Stephen J. Capuzzi, Senthil K. Muthuswamy, Jinhua Wang, Kenneth D. Westover, Ling Huang, Yan Liu, Alexander Tropsha, Eugene N. Muratov, Wayne Harshbarger
Publikováno v:
J Med Chem
Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that is overexpressed in gastrointestinal cancers, including esophageal, gastric, colorectal, and pancreatic cancers. DCLK1 is also used as a marker of tuft cells, which regulate type II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8da621f41453c4c3208e09367d26912
https://europepmc.org/articles/PMC8270059/
https://europepmc.org/articles/PMC8270059/
Autor:
Sung Wook Cho, Daniel Romo, Jeffrey W. Smith, Mingzhao Zhu, Robyn D. Richardson, Omar Robles, Stephan A. Sieber, Yanyan Yang, James T. Moore, Lindsey M. Spiegelman, Andres Garcia, Ju Anne Yau, James C. Sacchettini, Caitlen B. Walker, Wenshe R. Liu, Wayne Harshbarger, Joanna Krysiak, Bianca Ramirez, Christopher T. Wilson, Kenneth G. Hull
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2901-2916
The proteasome, a validated cellular target for cancer, is central for maintaining cellular homeostasis, while fatty acid synthase (FAS), a novel target for numerous cancers, is responsible for palmitic acid biosynthesis. Perturbation of either enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dd63de7753dc6b54c1cd3b5537b7f7
https://doi.org/10.1016/j.bmc.2017.01.020
https://doi.org/10.1016/j.bmc.2017.01.020
Autor:
Scott B. Ficarro, Kenneth D. Westover, Lianbo Li, William D. Singer, Yan Liu, Wayne Harshbarger, Durga Udayakumar, Jarrod A. Marto, John C. Hunter, Sudershan R. Gondi, Deepak Gurbani
Publikováno v:
Journal of Biological Chemistry. 292:112-120
Glutathione S-transferase pi 1 (GSTP1) is frequently overexpressed in cancerous tumors and is a putative target of the plant compound piperlongumine (PL), which contains two reactive olefins and inhibits proliferation in cancer cells but not normal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1767c89a72d8080076c18d34d1d7705b
https://doi.org/10.1074/jbc.m116.750299
https://doi.org/10.1074/jbc.m116.750299
Autor:
Lianbo Li, Caitlin E. Mills, Miljan Kuljanin, Joseph D. Mancias, Jinhua Wang, Sudershan R. Gondi, Kenneth D. Westover, Wayne Harshbarger, Fleur M. Ferguson, Kartik Subramanian, Peter K. Sorger, Nathanael S. Gray, Yan Liu
Publikováno v:
Cell Chemical Biology. 27:1229-1240.e4
Doublecortin-like kinase 1 (DCLK1) is critical for neurogenesis, but overexpression is also observed in multiple cancers and is associated with poor prognosis. Nevertheless, the function of DCLK1 in cancer, especially the context-dependent functions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e42817dd37e3d83c77129059c04267
https://doi.org/10.1016/j.chembiol.2020.07.011
https://doi.org/10.1016/j.chembiol.2020.07.011
Autor:
Nathanael S. Gray, Eugene N. Muratov, Alexander Tropsha, Stephen J. Capuzzi, Wayne Harshbarger, Jinhua Wang, Fleur M. Ferguson, Xianming Deng, Senthil K. Muthuswamy, Kenneth D. Westover, Ling Huang, Yan Liu
Publikováno v:
J Med Chem
Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that is overexpressed in gastrointestinal cancers, including esophageal, gastric, colorectal, and pancreatic cancers. DCLK1 is also used as a marker of tuft cells, which regulate type II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b7b233f60a552178e115580e1c2433
https://doi.org/10.1021/acs.jmedchem.0c01338
https://doi.org/10.1021/acs.jmedchem.0c01338