Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Wayne H. Miller"'
Autor:
Wayne H. Miller, MD, David Hsi, MD, Anna Koulova, MD, Andrey Vavrenyuk, MD, Isaac George, MD, Virendra Patel, MD, Hiroo Takayama, MD
Publikováno v:
JACC: Case Reports, Vol 2, Iss 15, Pp 2470-2475 (2020)
Aortic intramural hematoma accounts for 5% to 20% of patients with acute aortic syndrome. Endovascular grafts have evolved as minimally invasive alternatives for treatment in some highly selected patients. We present the case of a patient who had lat
Externí odkaz:
https://doaj.org/article/f13b26f6f87c4c0f9ac455dcb9e701c1
Autor:
Wayne H. Miller, MD, Sandhya Dhruvakumar, MD, Mina C. Owlia, MD, Greg R. D’Onofrio, MD, David Hsi, MD
Publikováno v:
JACC: Case Reports, Vol 2, Iss 5, Pp 814-818 (2020)
Atrial fibrillation is the most common arrhythmia in clinical practice with indication for anticoagulation in those patients whose annual risk for thromboembolism is >2%. Left atrial appendage closure is growing as an alternative to anticoagulation.
Externí odkaz:
https://doaj.org/article/c5cb32a12454455db0ecb8276ed7f43e
Autor:
Brian A. Johns, Takashi Kawasuji, Jason G. Weatherhead, Eric E. Boros, James B. Thompson, Edward P. Garvey, Scott A. Foster, Jerry L. Jeffrey, Wayne H. Miller, Noriyuki Kurose, Kenichi Matsumura, Tamio Fujiwara
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6461-6464
A series of naphthyridinone HIV-1 integrase strand-transfer inhibitors have been designed based on a psdeudo-C2 symmetry element present in the two-metal chelation pharmacophore. A combination of two distinct inhibitor binding modes resulted in poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543859790f45db50300fc75d2aaf2ab7
https://doi.org/10.1016/j.bmcl.2011.08.082
https://doi.org/10.1016/j.bmcl.2011.08.082
Autor:
Brian A. Johns, Jason G. Weatherhead, Scott H. Allen, James B. Thompson, Edward P. Garvey, Scott A. Foster, Jerry L. Jeffrey, Wayne H. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1802-1806
A series of HIV-1 integrase inhibitors containing a novel metal binding motif consisting of the 8-hydroxy-1,6-naphthyridine core and either an oxadiazole or triazole has been identified. The design of the key structural components was based on a two-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24900f240a3df8c8e7c8b961d3f826c2
https://doi.org/10.1016/j.bmcl.2009.01.090
https://doi.org/10.1016/j.bmcl.2009.01.090
Autor:
Edward P. Garvey, Brian A. Johns, Margaret J. Gartland, Scott A. Foster, Wayne H. Miller, Robert G. Ferris, Richard J. Hazen, Mark R. Underwood, Eric E. Boros, James B. Thompson, Jason G. Weatherhead, Cecilia S. Koble, Scott H. Allen, Lee T. Schaller, Ronald G. Sherrill, Tomokazu Yoshinaga, Masanori Kobayashi, Chiaki Wakasa-Morimoto, Shigeru Miki, Koichiro Nakahara, Takeshi Noshi, Akihiko Sato, Tamio Fujiwara
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:901-908
The naphthyridinone GSK364735 potently inhibited recombinant human immunodeficiency virus type 1 (HIV-1) integrase in a strand transfer assay (mean 50% inhibitory concentration ± standard deviation, 8 ± 2 nM). As expected based on the structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1ce24916536e22a701ee05912ccf1b
https://doi.org/10.1128/aac.01218-07
https://doi.org/10.1128/aac.01218-07
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5668-5672
An efficient synthesis of methyl 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-one-6-carboxylates (8-10 and 16) and 6-carboxamides (17-20) is described. Sub-micromolar enzyme inhibition of HIV integrase was achieved with several carboxamide analogs whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35636345c3bbfc079efbed0ad8cdfbc9
https://doi.org/10.1016/j.bmcl.2006.08.007
https://doi.org/10.1016/j.bmcl.2006.08.007
Autor:
Karen K. Biron, Eric A. Meade, John E. Reardon, Wayne H. Miller, Lilia M. Beauchamp, Albert A. Smith, Charles A. Goss, Richard L. Miller
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:341-356
A racemic mixture of ganciclovir phosphonate was resolved by stereoselective phosphorylation using GMP kinase. The R-enantiomer of ganciclovir phosphonate was active against human cytomegalovirus but the S-enantiomer was less active. We show that ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4a92a1dfc121d556957acf25d5856b
https://doi.org/10.1080/15257770008033013
https://doi.org/10.1080/15257770008033013
Autor:
Steven S. Good, M.B. Faletto, Edward P. Garvey, Wayne H. Miller, Susan Mary Daluge, M H St Clair
Publikováno v:
Antimicrobial Agents and Chemotherapy. 41:1099-1107
The anabolism of 1592U89, (-)-(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclo pentene-1-methanol, a selective inhibitor of human immunodeficiency virus (HIV), was characterized in human T-lymphoblastoid CD4+ CEM cells. 1592U89 was ulti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9d579aa875768927d86e1f4c04e92a
https://doi.org/10.1128/aac.41.5.1099
https://doi.org/10.1128/aac.41.5.1099
Autor:
Nanine A. VanDraanen, George Andrew Freeman, Ann Aulabaugh, Wayne H. Miller, George R. Painter, Lawrence R. Boone, Boyd Frank Leslie, Susan Mary Daluge, Jeanne E. Wilson, Michelle G. Davis
Publikováno v:
Antiviral Research. 30:133-145
DNA polymerase activity was assayed in hepatitis B virus (HBV) and core particles isolated from chronic producer lines. The particle-associated DNA polymerase activity, which was found to be limited to incorporation of only a few nucleotides, was inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84104b27347efdf8cf457bf7c6910c07
https://doi.org/10.1016/0166-3542(96)00938-2
https://doi.org/10.1016/0166-3542(96)00938-2
Publikováno v:
ChemInform. 24
3'-Azido-3'-deoxythymidine-5'-phosphonate was synthesized by a five-step reaction sequence. The 5'-phosphonate was inactive against HIV-1 in MT4 cells. The absence of activity against HIV-1 was at least partially explained by demonstrating that the K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c04a713892891f91610153fa2a43b013
https://doi.org/10.1002/chin.199301273
https://doi.org/10.1002/chin.199301273