Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.

Autor: Mateus A; Department of Pharmacy, Uppsala University, SE-751 23 Uppsala, Sweden., Gordon LJ; Platform Technology and Science, GlaxoSmithKline, SG1 2NY Stevenage, United Kingdom., Wayne GJ; Department of Target and Pathway Validation, GlaxoSmithKline, SG1 2NY Stevenage, United Kingdom., Almqvist H; Division of Translational Medicine, Laboratories for Chemical Biology, Chemical Biology Consortium Sweden, Science for Life Laboratory, Karolinska Institute, SE-171 65 Solna, Sweden.; Department of Medical Biochemistry & Biophysics, Chemical Biology, Karolinska Institute, SE-171 65 Solna, Sweden., Axelsson H; Division of Translational Medicine, Laboratories for Chemical Biology, Chemical Biology Consortium Sweden, Science for Life Laboratory, Karolinska Institute, SE-171 65 Solna, Sweden.; Department of Medical Biochemistry & Biophysics, Chemical Biology, Karolinska Institute, SE-171 65 Solna, Sweden., Seashore-Ludlow B; Division of Translational Medicine, Laboratories for Chemical Biology, Chemical Biology Consortium Sweden, Science for Life Laboratory, Karolinska Institute, SE-171 65 Solna, Sweden.; Department of Medical Biochemistry & Biophysics, Chemical Biology, Karolinska Institute, SE-171 65 Solna, Sweden., Treyer A; Department of Pharmacy, Uppsala University, SE-751 23 Uppsala, Sweden., Matsson P; Department of Pharmacy, Uppsala University, SE-751 23 Uppsala, Sweden., Lundbäck T; Division of Translational Medicine, Laboratories for Chemical Biology, Chemical Biology Consortium Sweden, Science for Life Laboratory, Karolinska Institute, SE-171 65 Solna, Sweden.; Department of Medical Biochemistry & Biophysics, Chemical Biology, Karolinska Institute, SE-171 65 Solna, Sweden., West A; Platform Technology and Science, GlaxoSmithKline, SG1 2NY Stevenage, United Kingdom., Hann MM; Platform Technology and Science, GlaxoSmithKline, SG1 2NY Stevenage, United Kingdom., Artursson P; Department of Pharmacy, Uppsala University, SE-751 23 Uppsala, Sweden; Per.Artursson@farmaci.uu.se.; Department of Pharmacy, Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Uppsala University, SE-751 23 Uppsala, Sweden.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Jul 25; Vol. 114 (30), pp. E6231-E6239. Date of Electronic Publication: 2017 Jul 12.

Molecular Evidence of Sexual Transmission of Ebola Virus.

Autor: Mate SE; From the Center for Genome Sciences (S.E.M., J.R.K., J.T.L., M.R.W., K.P., M.S.-L., G.P.) and Diagnostic Systems Division (R.J.S.), U.S. Army Medical Research Institute of Infectious Diseases, and the Division of Clinical Research, Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) (J.P., L.E.H., J.H.K.) - all in Frederick, MD; the Ministry of Health and Social Welfare (T.G.N., S.B.S., M.B., F.N.K.) and the World Health Organization (WHO) (G.J.D.-W., R.M.), Monrovia, and the Liberian Institute for Biomedical Research, Charlesville (L.F., F.T., F.B.) - all in Liberia; WHO, Geneva (T.C.-L., A.G., P.F.); the Centers for Disease Control and Prevention, Atlanta (A.C., B.W.H., U.S., D.J.B., A.S.L., D.E.W., T.L., S.T.N., K.M.D.C.); Illumina, San Diego, CA (G.P.S., S.M.G.); WHO, New Delhi, India (S.A.S); Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT (E.W., N.D., V.J.M., D.S.); Naval Medical Research Unit 3, Cairo (J.W.D.); and the Foundation Mérieux, Washington, DC (J.F.)., Kugelman JR, Nyenswah TG, Ladner JT, Wiley MR, Cordier-Lassalle T, Christie A, Schroth GP, Gross SM, Davies-Wayne GJ, Shinde SA, Murugan R, Sieh SB, Badio M, Fakoli L, Taweh F, de Wit E, van Doremalen N, Munster VJ, Pettitt J, Prieto K, Humrighouse BW, Ströher U, DiClaro JW, Hensley LE, Schoepp RJ, Safronetz D, Fair J, Kuhn JH, Blackley DJ, Laney AS, Williams DE, Lo T, Gasasira A, Nichol ST, Formenty P, Kateh FN, De Cock KM, Bolay F, Sanchez-Lockhart M, Palacios G

Publikováno v: The New England journal of medicine [N Engl J Med] 2015 Dec 17; Vol. 373 (25), pp. 2448-54. Date of Electronic Publication: 2015 Oct 14.

A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds.

Autor: Kaur R; 1GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, UK., Sloan LA, Blanchard AD, Smith JL, Churcher I, Wayne GJ, Ludbrook SB

Publikováno v: Journal of biomolecular screening [J Biomol Screen] 2013 Dec; Vol. 18 (10), pp. 1223-33. Date of Electronic Publication: 2013 Aug 27.

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.

Autor: Migaud ME; Oxford Centre for Molecular Sciences, Dyson Perrins Laboratory, South Parks Road, Oxford, UK OX1 3QY., Wilmouth RC, Mills GI, Wayne GJ, Risley C, Chambers C, Macdonald SJ, Schofield CJ

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2002 Jun 21 (12), pp. 1274-5.