Effect of mesenchymal precursor cells on the systemic inflammatory response and endothelial dysfunction in an ovine model of collagen-induced arthritis.

Autor: Laura M Dooley, Anwar Abdalmula, Elizabeth A Washington, Claire Kaufman, Elizabeth M Tudor, Peter Ghosh, Silviu Itescu, Wayne G Kimpton, Simon R Bailey

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0124144 (2015)

Mesenchymal precursor cells (MPC) are reported to possess immunomodulatory properties that may prove beneficial in autoimmune and other inflammatory conditions. However, their mechanism of action is poorly understood. A collagen-induced arthritis mod

Externí odkaz: https://doaj.org/article/182d416cb6414ed9acb8ff2972d47061

Lymphatic cannulation models in sheep: Recent advances for immunological and biomedical research

Autor: Christina M. Murray, Stuart R. Barber, Elizabeth A. Washington, Hung-Hsun Yen, Helen M. S. Davies, Wayne G. Kimpton

Publikováno v: Journal of Immunological Methods. 457:6-14

Lymphatic cannulation models are useful tools for studying the immunobiology of the lymphatic system and the immunopathology of specific tissues in diseases. Sheep cannulations have been used extensively, as models for human physiology, fetal and neo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76d3965258808e6980ac78ac0763a48
https://doi.org/10.1016/j.jim.2018.03.011

Inhibition of the KCa3.1 Channel Alleviates Established Pulmonary Fibrosis in a Large Animal Model

Autor: Barbara Bacci, Kenneth J. Snibson, Chrishan S. Samuel, Peter Bradding, Cameron J. Nowell, Wayne G. Kimpton, Katy M. Roach, Emmanuel Koumoundouros, Jade Jaffar, Louise Organ, Glen P. Westall

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 56:539-550

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease of increasing prevalence marked by poor prognosis and limited treatment options. Ca2+-activated KCa3.1 potassium channels have been shown to play a key role in the aberrant activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdb5405f8dcb973b61810f275e26b9d
https://doi.org/10.1165/rcmb.2016-0092oc

Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment

Autor: Albert E. Jergens, Cameron J. Nowell, Lina Maria Martinez Lopez, Wayne G. Kimpton, Caroline S Mansfield, Andrew Stent, Karin Allenspach, Julien R.S. Dandrieux, Simon M. Firestone

Publikováno v: Innate Immunity
Dandrieux, J R, Martinez Lopez, L M, Stent, A, Jergens, A, Allenspach, K, Nowell, C J, Firestone, S M, Kimpton, W & Mansfield, C S 2018, ' Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment ', Innate Immunity, vol. 24, no. 7, pp. 400-410 . https://doi.org/10.1177/1753425918799865

Chronic enteropathy (CE) in dogs is characterized retrospectively per treatment response as food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE) – the latter most resembling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bbebd05acc0035ca6fa6a50e277887
https://pubmed.ncbi.nlm.nih.gov/30223681

Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis

Autor: Laura M. Dooley, Jacqueline V. House, Wayne G. Kimpton, Claire Kaufman, Anwar Abdalmula, Elizabeth A. Washington, Peter Ghosh, Barbara Blacklaws, Silviu Itescu, Simon R. Bailey

Publikováno v: Stem Cell Research & Therapy. 8

BACKGROUND: The purpose of this study was to investigate the therapeutic efficacy of intravenously administered immunoselected STRO-3 + mesenchymal precursor cells (MPCs) on clinical scores, joint pathology and cytokine production in an ovine model o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ccfae1f81ac1dbc0a7d8bbd2988ff3
https://doi.org/10.1186/s13287-016-0460-7