Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Wayne F. Flintoff"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1690:110-117
Osteosarcomas are common primary malignant bone tumors that do not respond to conventional low-dose treatments of methotrexate (Mtx), suggesting an intrinsic resistance to this drug. Previous work has shown that cDNAs generated from osteosarcoma mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b98e14191001ad583c7f0eae32928cd
https://doi.org/10.1016/j.bbadis.2004.05.008
https://doi.org/10.1016/j.bbadis.2004.05.008
Publikováno v:
Virology
Following inoculation of continuous cell lines of neural and other derivations, persistent infections are established with facility by mouse hepatitis and measles viruses. This occurs equally with the prototype MHV3 and its neurotropic variant JHM as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0234a69f9eebcd9379e3fbacdd295f3
http://europepmc.org/articles/PMC7130880
http://europepmc.org/articles/PMC7130880
Publikováno v:
Journal of Biological Chemistry. 277:42105-42112
The reduced folate carrier (RFC) plays a critical role in the cellular uptake of folates. However, little is known regarding the mechanism used to transport substrates or the tertiary structure of the protein. Through the analysis of a Chinese hamste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04cdc2662708cd9807972feb239c99f
https://doi.org/10.1074/jbc.m206459200
https://doi.org/10.1074/jbc.m206459200
Publikováno v:
Biochemical Journal. 364:777-786
The reduced folate carrier (RFC) protein has a secondary structure consistent with the predicted 12 transmembrane (TM) domains, intracellular N- and C-termini and a large cytoplasmic loop between TM6 and TM7. In the present study, the role of the cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32728e2b9949ba3a0766bfa7c93bf36
https://doi.org/10.1042/bj20011361
https://doi.org/10.1042/bj20011361
Publikováno v:
Biochemical Journal. 346:509-518
The reduced-folate-carrier (rfc) gene has been shown to be functionally important for reduced-folate transport in mammalian cells. In the present paper we describe the identification of alterations in both alleles of the rfc gene in a mutant Chinese-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee0dd228348034e7c94f180d5dfaffe5
https://doi.org/10.1042/bj3460509
https://doi.org/10.1042/bj3460509
Publikováno v:
Somatic Cell and Molecular Genetics. 24:143-156
The reduced folate carrier (rfc 1 ) gene encodes a protein that is involved in the intracellular accumulation of folates. Point mutations in this gene and alterations resulting in the down regulation of its message are major factors involved in the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ef8b17e7b28786cbc123430f182b67
https://doi.org/10.1023/b:scam.0000007117.50428.63
https://doi.org/10.1023/b:scam.0000007117.50428.63
Autor:
Joseph R. Bertino, Madhu Mazumdar, Tanya M. Trippett, Richard Gorlick, Erdem Goker, Wayne F. Flintoff, Peter G. Steinherz, Yaroslav Elisseyeff
Publikováno v:
Blood. 89:1013-1018
Methotrexate (MTX) transport was examined in 27 patients with untreated acute lymphocytic leukemia (ALL) and 31 patients with relapsed ALL using a previously described fluorescent MTX analog (PT430) displacement assay (Blood 80:1158, 1992). Only 13%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd3fe57d27b8a480dbe05d838da664c
https://doi.org/10.1182/blood.v89.3.1013
https://doi.org/10.1182/blood.v89.3.1013
Autor:
Wayne F. Flintoff, N. Feingold, Marguerite Prieur, Dominique Vidaud, Michel Guilloud-Bataille, Michel Vidaud, Brigitte Assouline, Martine Le Merrer, Michel Bahuau, Arnold Munnich, Stanislas Lyonnet
Publikováno v:
American Journal of Medical Genetics. 66:347-355
A large four-generation family with Noonan syndrome (NS) and neurofibromatosis-type 1 (NF1) was studied for clinical association between the two diseases and for linkage analysis with polymorphic DNA markers of the NF1 region in 17q11.2. Nonrandom se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f03ee2ffc9a4d45207b67fe7b16b1165
https://doi.org/10.1002/(sici)1096-8628(19961218)66:3<347::aid-ajmg20>3.0.co
https://doi.org/10.1002/(sici)1096-8628(19961218)66:3<347::aid-ajmg20>3.0.co
Publikováno v:
Journal of Biological Chemistry. 269:5810-5816
A clone has been isolated from a Chinese hamster ovary cell cDNA expression library that complements mutant cells defective in the uptake of the folate analogue methotrexate. When transfected with this clone, the mutant cells regain the ability to bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f5d66e6439935a0d99f0d13aa0617e7
https://doi.org/10.1016/s0021-9258(17)37534-8
https://doi.org/10.1016/s0021-9258(17)37534-8
Autor:
Wayne F. Flintoff, François Marçon, Michel Bahuau, Arnold Munnich, Jacqueline Levilliers, S. Gilgenkrantz, Jean Kachaner, Martine Le Merrer, Stanislas Lyonnet, Didier Lacombe
Publikováno v:
American Journal of Medical Genetics. 46:700-705
A linkage analysis has been performed on 6 two-generation families with classical Noonan syndrome to determine whether the shydrome is linked to neurofibromatosis type 1 on chromosome 17q or to neurofibromatosis type 2 on chromosome 22q. A significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaaf62ffec3ac6496f12dce47586da30
https://doi.org/10.1002/ajmg.1320460621
https://doi.org/10.1002/ajmg.1320460621