Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Wayne D Tilley"'
Autor:
Dharmesh D. Bhuva, Chin Wee Tan, Agus Salim, Claire Marceaux, Marie A. Pickering, Jinjin Chen, Malvika Kharbanda, Xinyi Jin, Ning Liu, Kristen Feher, Givanna Putri, Wayne D. Tilley, Theresa E. Hickey, Marie-Liesse Asselin-Labat, Belinda Phipson, Melissa J. Davis
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Spatial molecular data has transformed the study of disease microenvironments, though, larger datasets pose an analytics challenge prompting the direct adoption of single-cell RNA-sequencing tools including normalization methods. Here, we de
Externí odkaz:
https://doaj.org/article/b13da81ba36848aea93f840263cbb1cf
Autor:
Leila Hosseinzadeh, Zoya Kikhtyak, Geraldine Laven-Law, Stephen M. Pederson, Caroline G. Puiu, Clive S. D’Santos, Elgene Lim, Jason S. Carroll, Wayne D. Tilley, Amy R. Dwyer, Theresa E. Hickey
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Background The androgen receptor (AR) is a tumor suppressor in estrogen receptor (ER) positive breast cancer, a role sustained in some ER negative breast cancers. Key factors dictating AR genomic activity in a breast context are largely unkn
Externí odkaz:
https://doaj.org/article/d7b51d564a0b4733aace68da8648cf13
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25634 (2011)
DNA methylation plays an important role in carcinogenesis and the reversibility of this epigenetic modification makes it a potential therapeutic target. To date, DNA methyltransferase inhibitors (DNMTi) have not demonstrated clinical efficacy in pros
Externí odkaz:
https://doaj.org/article/ac069471b82840efafe51910a383c3b8
Autor:
Neil Portman, Heloisa H. Milioli, Sarah Alexandrou, Rhiannon Coulson, Aliza Yong, Kristine J. Fernandez, Kee Ming Chia, Ensar Halilovic, Davendra Segara, Andrew Parker, Sue Haupt, Ygal Haupt, Wayne D. Tilley, Alex Swarbrick, C. Elizabeth Caldon, Elgene Lim
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-17 (2020)
Abstract Background Resistance to endocrine therapy is a major clinical challenge in the management of oestrogen receptor (ER)-positive breast cancer. In this setting, p53 is frequently wildtype and its activity may be suppressed via upregulation of
Externí odkaz:
https://doaj.org/article/b6f51a6926794f258d9ad544dc70f957
Autor:
Allegra Freelander, Geraldine laven-Law, Leila Eshraghi, Nimmy Geetha, Peta Somerville, Marie Pickering, Sarah Alexandrou, C. Elizabeth Caldon, Wayne D. Tilley, Theresa E. Hickey, Elgene Lim
Publikováno v:
Cancer Research. 83:P4-08
Background: The Androgen Receptor (AR) is expressed in up to 90% of all ER+ breast cancers and has been associated with better patient outcome. While androgens were used at a high dose as an anticancer therapy historically, this was discontinued with
Autor:
Xuan Huang, Gina Reye, Konstantin I. Momot, Tony Blick, Thomas Lloyd, Wayne D. Tilley, Theresa E. Hickey, Cameron E. Snell, Rachel K. Okolicsanyi, Larisa M. Haupt, Vito Ferro, Erik W. Thompson, Honor J. Hugo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/a0c13bb93e554fb7b5f4819b491b5e11
Autor:
Margaret M. Centenera, Theresa E. Hickey, Shalini Jindal, Natalie K. Ryan, Preethi Ravindranathan, Hisham Mohammed, Jessica L. Robinson, Matthew J. Schiewer, Shihong Ma, Payal Kapur, Peter D. Sutherland, Clive E. Hoffmann, Claus G. Roehrborn, Leonard G. Gomella, Jason S. Carroll, Stephen N. Birrell, Karen E. Knudsen, Ganesh V. Raj, Lisa M. Butler, Wayne D. Tilley
Publikováno v:
Molecular Oncology, Vol 12, Iss 9, Pp 1608-1622 (2018)
Breast and prostate cancer research to date has largely been predicated on the use of cell lines in vitro or in vivo. These limitations have led to the development of more clinically relevant models, such as organoids or murine xenografts that utiliz
Externí odkaz:
https://doaj.org/article/0552f838da6a4c13b4e0ce9e34c20273
Autor:
Karen E. Knudsen, Felix Y. Feng, Wayne D. Tilley, Lisa M. Butler, Margaret M. Centenera, John M. Pascal, Jonathan R. Brody, Adam P. Dicker, Ganesh V. Raj, Leonard G. Gomella, Peter McCue, Arul M. Chinnaiyan, Preethi Ravindranathan, Jamie L. Planck, Fengzhi Liu, Jeffry L. Dean, Michael A. Augello, J. Chad Brenner, Sumin Han, Jonathan F. Goodwin, Matthew J. Schiewer
PDF file - 410K, Dose responses, transcriptional, biological, biochemical, and in vivo supplemental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb680de7f27d4b56bbe4f736d76a3cc
https://doi.org/10.1158/2159-8290.22528551.v1
https://doi.org/10.1158/2159-8290.22528551.v1
Autor:
Karen E. Knudsen, Felix Y. Feng, Wayne D. Tilley, Lisa M. Butler, Margaret M. Centenera, John M. Pascal, Jonathan R. Brody, Adam P. Dicker, Ganesh V. Raj, Leonard G. Gomella, Peter McCue, Arul M. Chinnaiyan, Preethi Ravindranathan, Jamie L. Planck, Fengzhi Liu, Jeffry L. Dean, Michael A. Augello, J. Chad Brenner, Sumin Han, Jonathan F. Goodwin, Matthew J. Schiewer
PDF file - 91K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8265b108a2c8d6bb9ab863157403b50c
https://doi.org/10.1158/2159-8290.22528548
https://doi.org/10.1158/2159-8290.22528548
Autor:
Carmela Ricciardelli, David J. Horsfall, Wayne D. Tilley, Lisa M. Butler, Judith A. Clements, Gail P. Risbridger, Howard I. Scher, William L. Gerald, Susan M. Henshall, Robert L. Sutherland, Villis R. Marshall, Phillip D. Stricker, James G. Kench, Lisa G. Horvath, Wendy A. Raymond, Natalie K. Ryan, Melissa A. O'Loughlin, Marie A. Pickering, Mervyn Thomas, Tanya K. Day, Shalini Jindal, Grant Buchanan, Karen Chiam, Tina Bianco-Miotto
Supplementary Table 1 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfabc28d7100f4bd402f2bd8520bea3
https://doi.org/10.1158/1055-9965.22435549
https://doi.org/10.1158/1055-9965.22435549