Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Wayne Childers"'
Autor:
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J. Krais, Yifan Wang, Umeshkumar M. Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S. Chen, Richard T. Pomerantz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with homologous recombination (HR) factors and is therefore a promising drug target in BRCA1/2 mutant cancers. We discover an allosteric Polθ inhibitor (Pol
Externí odkaz:
https://doaj.org/article/a588334634d94054a3dac469d64b47e7
Autor:
Shelby Travaglianti, Ahmed Alotaibi, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Youssef Sari
Publikováno v:
Brain Research Bulletin, Vol 211, Iss , Pp 110935- (2024)
Chronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mPFC) and nucleus accumbens (NAc), and consequently leading to oxidative stress and neuroinflammat
Externí odkaz:
https://doaj.org/article/9d8e6c3717c14b58b334e7a4fcbbdf77
Autor:
Hanghang Zhang, Chen Huang, John Gordon, Sijia Yu, George Morton, Wayne Childers, Magid Abou-Gharbia, Yi Zhang, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Inhibition of cyclin-dependent kinase 9 (CDK9), a novel epigenetic target in cancer, can reactivate epigenetically silenced genes in cancer by dephosphorylating the SWI/SNF chromatin remodeler BRG1. Here, we characterized the anti
Externí odkaz:
https://doaj.org/article/892c78200eb14c6280a512cb5e5194fd
Autor:
Katherine Sullivan, Kimberly Cramer-Morales, Daniel L McElroy, David A Ostrov, Kimberly Haas, Wayne Childers, Robert Hromas, Tomasz Skorski
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147230 (2016)
It has been reported that inhibition of RAD52 either by specific shRNA or a small peptide aptamer induced synthetic lethality in tumor cell lines carrying BRCA1 and BRCA2 inactivating mutations. Molecular docking was used to screen two chemical libra
Externí odkaz:
https://doaj.org/article/d0ce38a5e77f4bc28620ce675bd9464d
Autor:
Hasan Alhaddad, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Edward Melenski, Richard L. Bell, Youssef Sari
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 383:208-216
Chronic ethanol exposure affects the glutamatergic system in several brain reward regions including the nucleus accumbens (NAc). Our laboratory has shown that chronic exposure to ethanol reduced the expression of glutamate transporter 1 (GLT-1) and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b059afd9bf3796be5d16793a73fa5e
https://doi.org/10.1124/jpet.122.001147
https://doi.org/10.1124/jpet.122.001147
Autor:
Huan Li, Srinivas Chatla, Xiaolei Liu, Umeshkumar Vekariya, Dongwook Kim, Matthew Walt, Zhaorui Lian, George Morton, Zijie Feng, Dan Yang, Hongjun Liu, Katherine Reed, Wayne Childers, Xiang Yu, Jozef Madzo, Kumaraswamy Naidu Chitrala, Tomasz Skorski, Jian Huang
Poly (ADP-ribose) polymerase (PARP) inhibitors represent a promising new class of agents that have demonstrated efficacy in treating various cancers, particularly those that carry BRCA1/2 mutations. The cancer associated BRCA1/2 mutations disrupt DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b3b3e9d73c925438442bc8942e4b85
https://doi.org/10.21203/rs.3.rs-2688694/v1
https://doi.org/10.21203/rs.3.rs-2688694/v1
Autor:
Umeshkumar M Vekariya, Katherine Sullivan-Reed, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Paulina Podszywalow-Bartnicka, Kumaraswamy Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Maslawska-Wasowska, Reza Nejati, Mariusz A Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth Paietta, Ross L. Levine, Martin S. Tallman, Hugo F Fernandez, Mark R. Litzow, Gaorav P Gupta, Jean-Yves Masson, Tomasz Skorski
Publikováno v:
Blood. 140:2972-2974
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cdc92bf4b188431d6466c66d0f43fb4
https://doi.org/10.1182/blood-2022-156458
https://doi.org/10.1182/blood-2022-156458
Autor:
Huan Li, Srinivas Chatla, Xiaolei Liu, Umeshkumar Vekariya, Dongwook Kim, Matthew Walt, Zhaorui Lian, George Morton, Zijie Feng, Dan Yang, Hongjun Liu, Katherine Sullivan-Reed, Wayne Childers, Xiang Yu, Jozef Madzo, Kumaraswamy Naidu Chitrala, Tomasz Skorski, Jian Huang
Poly (ADP-ribose) polymerase (PARP) inhibitors represent a promising new class of agents that have demonstrated efficacy in treating various cancers, particularly those that carryBRCA1/2mutations. The cancer associatedBRCA1/2mutations disrupt DNA dou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11bc9bc272e488cc96c5df770151bff7
https://doi.org/10.1101/2022.09.29.510119
https://doi.org/10.1101/2022.09.29.510119
Autor:
Lori A, Knackstedt, Lizhen, Wu, Jeffrey, Rothstein, Svetlana, Vidensky, John, Gordon, Mercy, Ramanjulu, Paul, Dunman, Benjamin, Blass, Wayne, Childers, Magid, Abou-Gharbia
Publikováno v:
J Pharmacol Exp Ther
Cocaine use disorder currently lacks Food and Drug Administration–approved treatments. In rodents, the glutamate transporter-1 (GLT-1) is downregulated in the nucleus accumbens after cocaine self-administration, and increasing the expression and fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2a5481c2900a3ff0c98f936df011b5c
https://pubmed.ncbi.nlm.nih.gov/33986035
https://pubmed.ncbi.nlm.nih.gov/33986035
Autor:
A Sami, Saribas, Pascale, Coric, Anahit, Hamazaspyan, William, Davis, Rachel, Axman, Martyn K, White, Magid, Abou-Gharbia, Wayne, Childers, Jon H, Condra, Serge, Bouaziz, Mahmut, Safak
Publikováno v:
Journal of cellular physiology. 231(10)
Agnoprotein is an important regulatory protein of polyomaviruses, including JCV, BKV, and SV40. In the absence of its expression, these viruses are unable to sustain their productive life cycle. It is a highly basic phosphoprotein that localizes most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::798118728e019fbb5cc8b6430a3aa0ac
https://pubmed.ncbi.nlm.nih.gov/27548512
https://pubmed.ncbi.nlm.nih.gov/27548512