Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Wayne C Koff"'
Autor:
Tongqing Zhou, Jiang Zhu, Yongping Yang, Jason Gorman, Gilad Ofek, Sanjay Srivatsan, Aliaksandr Druz, Christopher R Lees, Gabriel Lu, Cinque Soto, Jonathan Stuckey, Dennis R Burton, Wayne C Koff, Mark Connors, Peter D Kwong
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e99881 (2014)
One strategy for isolating or eliciting antibodies against a specific target region on the envelope glycoprotein trimer (Env) of the human immunodeficiency virus type 1 (HIV-1) involves the creation of site transplants, which present the target regio
Externí odkaz:
https://doaj.org/article/0f7a6f8436fd40ea83e54f4f03ef356f
Autor:
Marie Pancera, Yongping Yang, Mark K Louder, Jason Gorman, Gabriel Lu, Jason S McLellan, Jonathan Stuckey, Jiang Zhu, Dennis R Burton, Wayne C Koff, John R Mascola, Peter D Kwong
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55701 (2013)
Dozens of broadly neutralizing HIV-1 antibodies have been isolated in the last few years from the sera of HIV-1-infected individuals. Only a limited number of regions on the HIV-1 spike, however, are recognized by these antibodies. One of these regio
Externí odkaz:
https://doaj.org/article/7c90346bcbe447a0ae360024f0581623
Influence of HAART on alternative reading frame immune responses over the course of HIV-1 infection.
Autor:
Stephane Champiat, Rui André Saraiva Raposo, Nicholas J Maness, John L Lehman, Sean E Purtell, Aaron M Hasenkrug, Jacob C Miller, Hansi Dean, Wayne C Koff, Marisa Ailin Hong, Jeffrey N Martin, Steven G Deeks, Gerald E Spotts, Christopher D Pilcher, Fredrick M Hecht, Esper G Kallas, Keith E Garrison, Douglas F Nixon
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39311 (2012)
Translational errors can result in bypassing of the main viral protein reading frames and the production of alternate reading frame (ARF) or cryptic peptides. Within HIV, there are many such ARFs in both sense and the antisense directions of transcri
Externí odkaz:
https://doaj.org/article/fe9aa30c9e5d4ac59e0c53a7aff44b99
Autor:
Ann J Hessell, Eva G Rakasz, Pascal Poignard, Lars Hangartner, Gary Landucci, Donald N Forthal, Wayne C Koff, David I Watkins, Dennis R Burton
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000433 (2009)
Developing an immunogen that elicits broadly neutralizing antibodies (bNAbs) is an elusive but important goal of HIV vaccine research, especially after the recent failure of the leading T cell based HIV vaccine in human efficacy trials. Even if such
Externí odkaz:
https://doaj.org/article/d4adc7539358449187787e84059c5018
Autor:
Brian D. Aevermann, Casey P. Shannon, Mark Novotny, Rym Ben-Othman, Bing Cai, Yun Zhang, Jamie C. Ye, Michael S. Kobor, Nicole Gladish, Amy Huei-Yi Lee, Travis M. Blimkie, Robert E. Hancock, Alba Llibre, Darragh Duffy, Wayne C. Koff, Manish Sadarangani, Scott J. Tebbutt, Tobias R. Kollmann, Richard H. Scheuermann
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Vaccination to prevent infectious disease is one of the most successful public health interventions ever developed. And yet, variability in individual vaccine effectiveness suggests that a better mechanistic understanding of vaccine-induced immune re
Externí odkaz:
https://doaj.org/article/01893990f9944581a1f3cc78d5f56382
Autor:
Casey P. Shannon, Travis M. Blimkie, Rym Ben-Othman, Nicole Gladish, Nelly Amenyogbe, Sibyl Drissler, Rachel D. Edgar, Queenie Chan, Mel Krajden, Leonard J. Foster, Michael S. Kobor, William W. Mohn, Ryan R. Brinkman, Kim-Anh Le Cao, Richard H. Scheuermann, Scott J. Tebbutt, Robert E.W. Hancock, Wayne C. Koff, Tobias R. Kollmann, Manish Sadarangani, Amy Huei-Yi Lee
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
BackgroundVaccination remains one of the most effective means of reducing the burden of infectious diseases globally. Improving our understanding of the molecular basis for effective vaccine response is of paramount importance if we are to ensure the
Externí odkaz:
https://doaj.org/article/2b50d5dc445d48949f659ab881399fe1
Publikováno v:
Expert Review of Vaccines, Vol 16, Iss 6, Pp 535-544 (2017)
Biomedical research has become a data intensive science in which high throughput experimentation is producing comprehensive data about biological systems at an ever-increasing pace. The Human Vaccines Project is a new public–private partnership, wi
Externí odkaz:
https://doaj.org/article/4fddcb80fb924800b0294012b21c0703
Autor:
Stacey L. Wooden, Wayne C. Koff
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 14, Iss 9, Pp 2214-2216 (2018)
Although the success of vaccination to date has been unprecedented, our inadequate understanding of the details of the human immune response to immunization has resulted in several recent vaccine failures and significant delays in the development of
Externí odkaz:
https://doaj.org/article/0917f3684c7e49d980354c83b34f8d79
Publikováno v:
Journal of Molecular Biology. 435:168113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07ad396c9e33e6b2e9293d439bdd90b5
https://doi.org/10.1016/j.jmb.2023.168113
https://doi.org/10.1016/j.jmb.2023.168113
Autor:
Wouter Koudstaal, Galit Alter, Wayne C. Koff, Julia Wei Wu, Albert Hofman, Jaap Goudsmit, Theodore Schenkelberg, Anita Huiberdina Johanna van den Biggelaar, Michael J. Mina
Publikováno v:
European Journal of Epidemiology
The Human Immunomics Initiative (HII), a joint project between the Harvard T.H. Chan School of Public Health and the Human Vaccines Project (HVP), focuses on studying immunity and the predictability of immuneresponsiveness to vaccines in aging popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46867c211efa612bc8eb8db30d1fc970
https://doi.org/10.1007/s10654-021-00767-z
https://doi.org/10.1007/s10654-021-00767-z