Výsledky vyhledávání - "Wayne Brailsford"

Akademický článek

PI3Kγδ inhibition suppresses key disease features in a rat model of asthma

Autor: James W. Pinkerton, Silvia Preite, Antonio Piras, Dimitrios Zervas, Thomais Markou, Mark S. Freeman, Tobias Hofving, Emil Ivarsson, Sara J. Bonvini, Wayne Brailsford, Linda Yrlid, Maria G. Belvisi, Mark A. Birrell

Publikováno v: Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)

Abstract Background Two isoforms of Phosphoinositide 3-kinase (PI3K), p110γ and p110δ, are predominantly expressed in leukocytes and represent attractive therapeutic targets for the treatment of allergic asthma. The study aim was to assess the impa

Externí odkaz: https://doaj.org/article/34e0cce183ac4d01b5e4f1bcb2a5c774

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Diurnal variation in DLCO and non-standardized study procedures may cause a false positive safety signal in clinical trials

Autor: Krishna Tulasi Kirla, Szilárd Nemes, Joanne Betts, Cecilia Kristensson, John Mo, Sara Asimus, Muhammad Waqas Sadiq, Elke Redlich, Thomas Koernicke, Rainard Fuhr, Wayne Brailsford, Christina Keen, Anette Hagberg, Jukka Mäenpää

Publikováno v: Respiratory medicine. 191

Diffusing capacity for carbon monoxide (DLCO) was measured in a phase I single ascending dose study after inhalation of AZD8154 or placebo in healthy participants at baseline (DLCO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4716f829706706e8dea5cf41e8916957
https://pubmed.ncbi.nlm.nih.gov/34879298

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Characterisation of pharmacokinetics, safety and tolerability in a first-in-human study for AZD8154, a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease

Autor: Cecilia Kristensson, Jukka Mäenpää, Rainard Fuhr, Wayne Brailsford, Thomas Körnicke, Tina Jellesmark Jensen, Mahdi Hashemi, Joanne Betts, Sofia Necander, Julia Jonsson, Anette Hagberg, Szilard Nemes, Rebecca Fransson, Maria G. Belvisi, Muhammad Waqas Sadiq, Sara Asimus, Christina Keen

Publikováno v: British journal of clinical pharmacologyREFERENCES. 88(1)

Aims This 3-part, randomised, phase 1 first-in-human study (NCT03436316) investigated the safety, tolerability and pharmacokinetics (PK) of AZD8154, a dual phosphoinositide 3-kinase (PI3K) γδ inhibitor developed as a novel inhaled anti-inflammatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4524abc8321a099d65c5d5ca89c1ae66
https://pubmed.ncbi.nlm.nih.gov/34182611

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Safety, Tolerability and Pharmacokinetics (PK) of AZD8154, A Selective PI3Kγδ Inhibitor, After Single and Multiple Ascending Inhaled Doses in Healthy Volunteers

Autor: Cecilia Kristensson, Jukka Mäenpää, Christina Keen, Szilard Nemes, Joanne Betts, T. Koernicke, T. Jellesmark Jensen, Rainard Fuhr, A. Hagberg, Sofia Necander, Sara Asimus, W.M. Sadiq, Wayne Brailsford

Publikováno v: B31. ASTHMA CLINICAL TRIALS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93b0d5bf13fc130b8c24c3dfc777dfd5
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3022

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Reducing the variability of DLCO measurements in clinical trials

Autor: Sara Asimus, Muhammad Waqas Sadiq, Christina Keen, Cecilia Kristensson, Jukka Mäenpää, Wayne Brailsford, Rainard Fuhr, John Mo, Thomas Koernicke, Joanne Betts, Anette Hagberg

Publikováno v: Monitoring airway disease.

Introduction: Measuring diffusing capacity of the lung for carbon monoxide (DLCO) facilitates the diagnosis, classification and monitoring of various lung diseases, and may also be used for safety signal detection in clinical drug development. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85ea1c9c31368be62c11fa39c39c53e9
https://doi.org/10.1183/13993003.congress-2019.pa2650

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Safety, tolerability and pharmacokinetics (PK) of AZD8154 (a selective PI3K?d inhibitor) after single ascending inhaled doses in healthy volunteers

Autor: Muhammad Waqas Sadiq, Christina Keen, Anette Hagberg, Joanne Betts, Jukka Mäenpää, Wayne Brailsford, Thomas Koernicke, Barbara Valastro, Cecilia Kristensson, Sara Asimus, Rainard Fuhr

Publikováno v: Airway pharmacology and treatment.

AZD8154 is an inhaled PI3Kgd inhibitor developed for treatment of asthma. This first in human study evaluate the safety, tolerability and PK of AZD8154 in healthy volunteers after inhalation of single ascending doses (Part 1) and characterized the sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25b7f2de45f189551d70a25796f105fc
https://doi.org/10.1183/13993003.congress-2019.pa4220

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Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs

Autor: Wayne Brailsford, Neville D. Yeomans, Jorgen Naesdal, Christopher J. Hawkey

Publikováno v: Current Medical Research and Opinion. 25:2785-2793

Low-dose acetylsalicylic acid (ASA; aspirin; 75-325 mg/day) is effective for the prevention of cardiovascular events, and its use in this indication is rapidly increasing. However, the use of ASA and, indeed, other non-steroidal anti-inflammatory dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7df635296820b88abac30efbdd9b060
https://doi.org/10.1185/03007990903212682

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Discovery and Optimization of a Series of Carbazole Ureas as NPY5 Antagonists for the Treatment of Obesity

Publikováno v: Journal of Medicinal Chemistry. 45:3509-3523

The hypothesis that antagonists of the neuropeptide Y5 receptor would provide safe and effective appetite suppressants for the treatment of obesity has prompted vigorous research to identify suitable compounds. We discovered a series of acylated amin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0028b2565d75e49c0cc2a1f31a51be3d
https://doi.org/10.1021/jm011125x

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Fe(III) mediated oxidative radical cyclisation of cyclopropanone acetals

Autor: Kevin I. Booker-Milburn, Brian Cox, Wayne Brailsford, Andy Barker, Tamsin E. Mansley

Publikováno v: Tetrahedron. 54:15321-15344

A variety of cyclopropanone acetal derivatives were found to undergo facile Fe(III) mediated oxidative radical cyclisation to the corresponding trisubstituted cyclopentane esters in good yield and with diastereoselectivities as high as 23:1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09e20c304f88c9bdaa08e2d7a81a95ac
https://doi.org/10.1016/s0040-4020(98)00958-2

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Diastereoselective Fe(III) mediated oxidative cyclisation reactions of cyclopropanone acetals

Autor: Andy Barker, Kevin I. Booker-Milburn, Wayne Brailsford

Publikováno v: Tetrahedron Letters. 39:4373-4376

Substituted cyclopropanone acetal derivatives undergo facile Fe(III) mediated oxidative cyclisation to the corresponding trisubstituted cyclopentane esters in good yield and with diastereoselectivities as high as 23:1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f11dd22a70c9d0e7427991914499960
https://doi.org/10.1016/s0040-4039(98)00704-7

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