Expression of natural killer cell regulatory microRNA by uveal melanoma cancer stem cells

Autor: Arun D. Singh, Pierre L. Triozzi, Powrnima Joshi, Daniel Varghai, Maciej Zborowski, Wayne Aldrich, Mitra Kooshki

Publikováno v: Clin Exp Metastasis

Natural killer (NK) cells are implicated in the control of metastasis in uveal melanoma, a process that has been ascribed to its cancer stem cell subpopulation. NK cell activation is regulated by specific microRNA (miR). The NK cell sensitivity and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb0925c36a17965c673734e632f3619
https://pubmed.ncbi.nlm.nih.gov/27565163

Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo

Autor: Zhenbo Hu, Pierre L. Triozzi, Soledad Negrotto, Wayne Aldrich, Yogen Saunthararajah, Susan Achberger, Oscar Alcazar

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Apoptosis genes, such as TP53 and p16/CDKN2A, that mediate responses to cytotoxic chemotherapy, are frequently nonfunctional in melanoma. Differentiation may be an alternative to apoptosis for inducing melanoma cell cycle exit. Epigenetic mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7533b145e5ea6e5bc9f5f3d18ed3564
https://doi.org/10.1002/ijc.26320

Differential effects of imatinib mesylate against uveal melanoma in vitro and in vivo

Autor: Christopher Dombos, Wayne Aldrich, Pierre L. Triozzi

Publikováno v: Melanoma Research. 18:420-430

Uveal melanoma is refractory to chemotherapy. The receptor tyrosine kinase inhibitor, imatinib mesylate, has demonstrated antiproliferative effects against uveal melanoma cells in vitro. The effects of imatinib mesylate, alone and combined with the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738bd48f9f941b0f5650357b18ac71ed
https://doi.org/10.1097/cmr.0b013e3283194118

Bisphosphonates Inhibit the Growth of Mesothelioma Cells In vitro and In vivo

Autor: Telisha Millender-Swain, Kevin W. Harris, Savita Wakchoure, Katri S. Selander, Pierre L. Triozzi, Wayne Aldrich, Melinda A. Merrell

Publikováno v: Clinical Cancer Research. 12:2862-2868

Purpose: Bisphosphonates (such as risedronate and zoledronate) are widely used inhibitors of bone resorption. Despite their in vitro antiproliferative effects in various cancer cells, bisphosphonates have not exhibited significant antitumor efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae152ded5f0f6a049d613f4250fdbdc
https://doi.org/10.1158/1078-0432.ccr-05-2766

High efficiency transduction of dendritic cells by adenoviral vectors targeted to DC-SIGN

Autor: Rik J. Scheper, Tanja D. de Gruijl, Joanne T. Douglas, Stephen D. Gillies, Nikolay Korokhov, Tyler J. Curiel, Pierre L. Triozzi, Wayne Aldrich, David T. Curiel, Papia T. Banerjee

Publikováno v: Korokhov, N, De Gruijl, T D, Aldrich, W A, Triozzi, P L, Banerjee, P T, Gillies, S D, Curiel, T J, Douglas, J T, Scheper, R J & Curiel, D T 2005, ' High efficiency transduction of dendritic cells by adenoviral vectors targeted to DC-SIGN ', Cancer Biology and Therapy, vol. 4, no. 3, pp. 289-294 . https://doi.org/10.4161/cbt.4.3.1499
Cancer Biology and Therapy, 4(3), 289-294

Dendritic cells (DCs) are a central element in the development of antigen-specific immune responses. The lack of a specific and efficient technique for the in vivo delivery of antigens to DCs remains a major obstacle limiting a vaccine's ability to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cff943f1e3ba5b6271ee4225ac0d25
http://www.scopus.com/inward/record.url?scp=25144471635&partnerID=8YFLogxK