Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Wayne A. Speckmann"'
Autor:
Wayne A. Speckmann, Niamh M. Cahill, Zhu-Hong Li, Joan A. Steitz, Rebecca M. Terns, Michael P. Terns, Kyle Friend
Publikováno v:
The EMBO Journal. 21:3816-3828
Methylation of the ribose 2'-hydroxyl, the most widespread modification of ribosomal and splicesomal RNAs, is guided by the box C/D class of small nucleolar RNAs (snoRNAs). Box C/D small nucleolar ribonucleoproteins (snoRNPs) contain four core protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6837bf2ba0d57d78f112d700a6fb278b
https://doi.org/10.1093/emboj/cdf376
https://doi.org/10.1093/emboj/cdf376
Autor:
Todd M. Lowe, Rebecca M. Terns, Michael P. Terns, Wayne A. Speckmann, Zhu-Hong Li, Sean R. Eddy
Publikováno v:
Current Biology. 12:199-203
In eukaryotes, many Box C/D small nucleolar RNAs base pair with ribosomal RNA through short complementary guide sequences, thereby marking up to 100 individual nucleotides of ribosomal RNA for 2′-O-methylation [1–3]. Function of the eukaryotic Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c204b8fe19f1b383343d638f5454ccea
https://doi.org/10.1016/s0960-9822(02)00655-3
https://doi.org/10.1016/s0960-9822(02)00655-3
Publikováno v:
Nucleic Acids Research. 28:4467-4473
The 5'-cap structure of most spliceosomal small nuclear RNAs (snRNAs) and certain small nucleolar RNAs (snoRNAs) undergoes hypermethylation from a 7-methylguanosine to a 2,2, 7-trimethylguanosine structure. 5'-Cap hypermethylation of snRNAs is depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a56858ca611a4f331d72b375ffec94
https://doi.org/10.1093/nar/28.22.4467
https://doi.org/10.1093/nar/28.22.4467
Publikováno v:
Molecular and Cellular Biology. 19:8412-8421
The processing and methylation of precursor rRNA is mediated by the box C/D small nucleolar RNAs (snoRNAs). These snoRNAs differ from most cellular RNAs in that they are not exported to the cytoplasm. Instead, these RNAs are actively retained in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314b094c9f1943322a1dce7eb9633cf2
https://doi.org/10.1128/mcb.19.12.8412
https://doi.org/10.1128/mcb.19.12.8412
Publikováno v:
Molecular Biology of the Cell. 10:2131-2147
Small nucleolar RNAs (snoRNAs) are a large family of eukaryotic RNAs that function within the nucleolus in the biogenesis of ribosomes. One major class of snoRNAs is the box C/D snoRNAs named for their conserved box C and box D sequence elements. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e3f1f129a85f9eac7f9c7c7931b6e2
https://doi.org/10.1091/mbc.10.7.2131
https://doi.org/10.1091/mbc.10.7.2131
Autor:
Wayne A. Speckmann, Wei Zheng, James Hoberg, Mark Santos, Arazo Saadat, Reshmie Shea, Sheri Geiman
Publikováno v:
Cancer Research. 76:176-176
Phosphorylation of proteins is one of the most common forms of post-translational modification (PTMs) and is a mechanism for regulating enzyme activity or protein function. There are several amino acids that can be phosphorylated but despite its impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f40f516eabe12f91ebc49c0ad61bc4
https://doi.org/10.1158/1538-7445.am2016-176
https://doi.org/10.1158/1538-7445.am2016-176
Autor:
Michele Hatler, Robert Brockett, Chandra Mohan, Wayne A. Speckmann, Chun Yang, Kevin Long, Xiaoyi Xu
Publikováno v:
Cancer Research. 75:5045-5045
A major focus of breast cancer research is to understand the mechanisms responsible for disease progression and drug resistance. Most treatment options target endocrine therapy, however, the processes that modulate these signaling pathways are poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6918aa2b0bff7446bf94e8ecf4fc42
https://doi.org/10.1158/1538-7445.am2015-5045
https://doi.org/10.1158/1538-7445.am2015-5045
Autor:
Trinette Chuang, Peter W. Lewis, John M. Rosenfeld, Oren J. Becher, David C. Allis, Sturges Michael, Anita Lozsa, Alejandra Solache, Matthew S. Koletsky, Robin T. Clark, Wayne A. Speckmann
Publikováno v:
Cancer Research. 74:A32-A32
Pediatric gliomas such as glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG) are aggressive brain tumors for which there is no effective therapy. The reason for the poor therapeutic outcome for children diagnosed with glioblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::733a8e0e070bdbcf17234a5b6abc5112
https://doi.org/10.1158/1538-7445.pedcan-a32
https://doi.org/10.1158/1538-7445.pedcan-a32
Autor:
Wayne A. Speckmann, Sander Granneman, Kevin W. Jones, Michael P. Terns, Helma Pluk, Rebecca M. Terns, Sharon A. Mattox, Walther J. van Venrooij, Andrew A. Lukowiak
Publikováno v:
Nucleic acids research. 28(18)
U3 small nucleolar RNA (snoRNA) is a member of the Box C/D family of snoRNAs which functions in ribosomal RNA processing. U3-55k is a protein that has been found to interact with U3 but not other members of the Box C/D snoRNA family. We have found th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8a275f12ff4797382516f1ff4c1b45
https://pubmed.ncbi.nlm.nih.gov/10982864
https://pubmed.ncbi.nlm.nih.gov/10982864
Publikováno v:
Molecular Cancer Research. 11:B064-B064
Resistance to tamoxifen is one of the major challenges in breast cancer treatment. Different mechanisms related to tamoxifen sensitivity have been widely investigated, including the phosphorylation of ERα. It has been shown experimentally that phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50138f7f644453dc12c913104b79fa8e
https://doi.org/10.1158/1557-3125.advbc-b064
https://doi.org/10.1158/1557-3125.advbc-b064