Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Wayne A. Schroder"'
Autor:
Darren C. Holland, Dale W. Prebble, Mark J. Calcott, Wayne A. Schroder, Francesca Ferretti, Aaron Lock, Vicky M. Avery, Milton J. Kiefel, Anthony R. Carroll
Publikováno v:
Molecules, Vol 29, Iss 15, p 3648 (2024)
Marine natural products (MNPs) continue to be tested primarily in cellular toxicity assays, both mammalian and microbial, despite most being inactive at concentrations relevant to drug discovery. These MNPs become missed opportunities and represent a
Externí odkaz:
https://doaj.org/article/f89cc53b0fe941b8a953a64e5fcc6f23
Autor:
Jemma Nicholls, Benjamin Cao, Laetitia Le Texier, Laura Yan Xiong, Christopher R. Hunter, Genesis Llanes, Ethan G. Aguliar, Wayne A. Schroder, Simon Phipps, Jason P. Lynch, Huimin Cao, Shen Y. Heazlewood, Brenda Williams, Andrew D. Clouston, Christian M. Nefzger, Jose M. Polo, Susan K. Nilsson, Bruce R. Blazar, Kelli P. A. MacDonald
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Regulatory T cell (Treg) reconstitution is essential for reestablishing tolerance and maintaining homeostasis following stem-cell transplantation. We previously reported that bone marrow (BM) is highly enriched in autophagy-dependent Treg and autopha
Externí odkaz:
https://doaj.org/article/27d02299a5ee475cab524537e8e3a0b4
Autor:
Ian D. Tonks, Arne W. Mould, Wayne A. Schroder, Andrew Cotterill, Nicholas K. Hayward, Graeme J. Walker, Graham F. Kay
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 3, Pp 235-243 (2010)
Using a Cre/loxP system, we have determined the phenotypic consequences attributable to in vivo deletion of both Rb1 and Trp53 in the mouse adrenal medulla. The coablation of these two tumor suppressor genes during embryogenesis did not disrupt adren
Externí odkaz:
https://doaj.org/article/416ad00bde0c48d59ac534a71f89d508
Autor:
Thuy T Le, Kresten Skak, Kate Schroder, Wayne A Schroder, Glen M Boyle, Carly J Pierce, Andreas Suhrbier
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153975 (2016)
Ingenol mebutate is approved for the topical treatment of actinic keratoses and may ultimately also find utility in treating skin cancers. Here we show that relapse rates of subcutaneous B16 melanoma tumours treated topically with ingenol mebutate we
Externí odkaz:
https://doaj.org/article/24fac0083b674dda89eb20ed9aef36be
Autor:
Joy Gardner, Penny A Rudd, Natalie A Prow, Essia Belarbi, Pierre Roques, Thibaut Larcher, Lionel Gresh, Angel Balmaseda, Eva Harris, Wayne A Schroder, Andreas Suhrbier
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139481 (2015)
Chikungunya virus (CHIKV) is a reemerging, ordinarily mosquito-transmitted, alphavirus that occasionally produces hemorrhagic manifestations, such as nose bleed and bleeding gums, in human patients. Interferon response factor 3 and 7 deficient (IRF3/
Externí odkaz:
https://doaj.org/article/a1509080062b4146be77457cb14fca0f
Autor:
Bruce R. Blazar, Gregory Miller, Wei Chen, Jing Liu, Melanie S. Nyuydzefe, Geoffrey R. Hill, Katharine M. Irvine, Michelle Melino, Wayne A. Schroder, Patrick Bertolino, Kelli P. A. MacDonald, Alexandra Zanin-Zhorov, Michele W.L. Teng, Christina Nalkurthi, Andrew D. Clouston
Publikováno v:
JHEP Reports
Background & Aims Fibrosis, the primary cause of morbidity in chronic liver disease, is induced by pro-inflammatory cytokines, immune cell infiltrates, and tissue resident cells that drive excessive myofibroblast activation, collagen production, and
Autor:
Stefan Rose-John, Jana Vukovic, Adahir Labrador Garrido, Marc J. Ruitenberg, Wayne A. Schroder, Ellen R. Gillespie, Kelli P. A. MacDonald, Emily F. Willis, Daniel C. Anthony, Quan Nguyen, Perry F. Bartlett, Abi G. Yates, Samuel B. R. Harley
Publikováno v:
Cell. 180(5)
Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet whether these cells contribute to cognitive deficits and secondary inflammatory pathology remains poorly understood. Here, we show that removal of microgl
Autor:
Thiago Dominguez Crespo Hirata, Itaru Anraku, Thuy T. Le, Lee Major, Jonathan Ellis, Andreas Suhrbier, Wayne A. Schroder, Helder I. Nakaya
Publikováno v:
The American Journal of Pathology. 186:1511-1523
SerpinB2 (plasminogen activator inhibitor type 2) is constitutively expressed at high levels by differentiating keratinocytes in mice and humans; however, the physiological function of keratinocyte SerpinB2 remains unclear. Herein, we show that Serpi
Autor:
Joy Gardner, Eri Nakayama, Jonathan Ellis, Glen M. Boyle, Wayne A. Schroder, Andreas Suhrbier, Thuy T. Le, Helder I. Nakaya, Thiago Dominguez Crespo Hirata, Dilan Pathirana
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
SerpinB2 (plasminogen activator inhibitor type 2) has been called the “undecided serpin” with no clear consensus on its physiological role, although it is well described as an inhibitor of urokinase plasminogen activator (uPA). In macrophages, pr
Autor:
Joy Gardner, Thuy T. Le, Andreas Suhrbier, Robert K. Andrews, Elizabeth E. Gardiner, Leonie K. Callaway, Wayne A. Schroder
SerpinB2, also known as plasminogen activation inhibitor type 2 (PAI-2), is classically viewed as an inhibitor of fibrinolysis. However, we show herein a distinct, hitherto unrecognized role for SerpinB2 in hemostasis. Mice deficient in SerpinB2 expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cd99e05aadd3e27cc553e3abee6281