Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Wayne A. Hendrickson"'
Autor:
Wayne A. Hendrickson
Publikováno v:
IUCrJ, Vol 10, Iss 5, Pp 521-543 (2023)
The marvel of X-ray crystallography is the beauty and precision of the atomic structures deduced from diffraction patterns. Since these patterns record only amplitudes, phases for the diffracted waves must also be evaluated for systematic structure d
Externí odkaz:
https://doaj.org/article/a4823e5e22364a4f821e54923b297af5
Autor:
Akira Karasawa, Babak Andi, Martin R. Fuchs, Wuxian Shi, Sean McSweeney, Wayne A. Hendrickson, Qun Liu
Publikováno v:
IUCrJ, Vol 9, Iss 6, Pp 768-777 (2022)
De novo structure determination from single-wavelength anomalous diffraction using native sulfur or phosphorus in biomolecules (native-SAD) is an appealing method to mitigate the labor-intensive production of heavy-atom derivatives and selenomethiony
Externí odkaz:
https://doaj.org/article/cdde9f568aa44ab097796623e1a935fe
Autor:
Aaron P. Owji, Jiali Wang, Alec Kittredge, Zada Clark, Yu Zhang, Wayne A. Hendrickson, Tingting Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Bestrophin channels are critical for physiology of the eye. Here, authors report cryo-EM structures of human bestrophins in various states at up to 1.8 Å resolution, revealing paralog-specific features that underlie molecular mechanisms of permeatio
Externí odkaz:
https://doaj.org/article/f20545733ff64a9199865a3c3234ef9b
Autor:
Jonah Cheung, Shagun Wazir, David R. Bell, James N. Kochenderfer, Wayne A. Hendrickson, Philippe Youkharibache
Publikováno v:
Crystals, Vol 13, Iss 4, p 710 (2023)
Chimeric Antigen Receptor T-cell (CAR-T) immunotherapies are dependent upon designed transmembrane proteins to bind target antigens and stimulate an immune response. The success or failure of these CARs is only partially predictable, yet recent work
Externí odkaz:
https://doaj.org/article/bef20e38c71d4077a3662f17bc19d8ae
Publikováno v:
Crystals, Vol 13, Iss 2, p 183 (2023)
Na+ is the most abundant ion in living organisms and plays essential roles in regulating nutrient uptake, muscle contraction, and neurotransmission. The identification of Na+ in protein structures is crucial for gaining a deeper understanding of prot
Externí odkaz:
https://doaj.org/article/a1c891adc6d14ed0a8819f10c9d8b87e
Autor:
Gongrui Guo, Ping Zhu, Martin R. Fuchs, Wuxian Shi, Babak Andi, Yuan Gao, Wayne A. Hendrickson, Sean McSweeney, Qun Liu
Publikováno v:
IUCrJ, Vol 6, Iss 4, Pp 532-542 (2019)
De novo structural evaluation of native biomolecules from single-wavelength anomalous diffraction (SAD) is a challenge because of the weakness of the anomalous scattering. The anomalous scattering from relevant native elements – primarily sulfur in
Externí odkaz:
https://doaj.org/article/48daad430ea34ebbabe12fd621fa4ad2
Autor:
Wayne A. Hendrickson
Publikováno v:
QRB Discovery, Vol 1 (2020)
Heat-shock proteins of 70 kDa (Hsp70s) are ubiquitous molecular chaperones that function in protein folding as well as other vital cellular processes. They bind and hydrolyze ATP in a nucleotide-binding domain (NBD) to control the binding and release
Externí odkaz:
https://doaj.org/article/b95c326ad8944a1a872363b91751f896
Autor:
Gongrui Guo, Martin R. Fuchs, Wuxian Shi, John Skinner, Evanna Berman, Craig M. Ogata, Wayne A. Hendrickson, Sean McSweeney, Qun Liu
Publikováno v:
IUCrJ, Vol 5, Iss 3, Pp 238-246 (2018)
With the recent developments in microcrystal handling, synchrotron microdiffraction beamline instrumentation and data analysis, microcrystal crystallography with crystal sizes of less than 10 µm is appealing at synchrotrons. However, challenges rema
Externí odkaz:
https://doaj.org/article/35890da97f3449179712be93de370bc4
Autor:
Cheyenne Chaplain, Christopher J. Fritschi, Saumya Anang, Zhen Gong, Jonathan Richard, Catherine Bourassa, Shuaiyi Liang, Mohammadjavad Mohammadi, Jun Park, Andrés Finzi, Navid Madani, Joseph G. Sodroski, Cameron F. Abrams, Wayne A. Hendrickson, Amos B. Smith
Publikováno v:
ACS Medicinal Chemistry Letters. 14:51-58
Autor:
Christopher Fritschi, Saumya Anang, Zhen Gong, Mohammadjavad Mohammadi, Jonathan Richard, Catherine Bourassa, Kenny T. Severino, Hannah Richter, Derek Yang, Hung-Ching Chen, Ta-Jung Chiu, Michael Seaman, Navid Madani, Cameron Abrams, Andrés Finzi, Wayne A. Hendrickson, Joseph Sodroski, Amos B. Smith
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Binding to the host cell receptors, CD4 and CCR5/CXCR4, triggers large-scale conformational changes in the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer [(gp120/gp41)3] that promote virus entry into the cell. CD4-mimetic com