Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Wayne A. Border"'
Publikováno v:
American Journal of Physiology-Renal Physiology. 303:F11-F20
While elevated plasma prorenin levels are commonly found in diabetic patients and correlate with diabetic nephropathy, the pathological role of prorenin, if any, remains unclear. Prorenin binding to the (pro)renin receptor [(p)RR] unmasks prorenin ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48be8b5e431f3ccc360c97c716498c5f
https://doi.org/10.1152/ajprenal.00050.2012
https://doi.org/10.1152/ajprenal.00050.2012
Publikováno v:
American Journal of Physiology-Renal Physiology. 298:F579-F588
Recent identification of a counterregulatory axis of the renin-angiotensin system, called angiotensin-converting enzyme 2-angiotensin-(1–7) [ANG-(1–7)]-Mas receptor, may offer new targets for the treatment of renal fibrosis. We hypothesized that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62268a801eed4c94b864b84fb4743b17
https://doi.org/10.1152/ajprenal.00548.2009
https://doi.org/10.1152/ajprenal.00548.2009
Publikováno v:
American Journal of Physiology-Renal Physiology. 297:F1045-F1054
Administration of a mutant, noninhibitory PAI-1 (PAI-1R), reduces disease in experimental glomerulonephritis. Here we investigated the importance of vitronectin (Vn) binding, PAI-1 stability and protease binding in this therapeutic effect using a pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568553a063c3d36869b2292cd34a498e
https://doi.org/10.1152/ajprenal.00024.2009
https://doi.org/10.1152/ajprenal.00024.2009
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 295:E810-E819
Although elevated plasma prorenin levels are commonly found in diabetic patients and correlate with microvascular complications, the pathological role of these increases, if any, remains unclear. Prorenin/renin binding to the prorenin/renin receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c93e1f04dcd27132b714d39cd84930
https://doi.org/10.1152/ajpendo.90264.2008
https://doi.org/10.1152/ajpendo.90264.2008
Publikováno v:
American Journal of Physiology-Renal Physiology. 294:F1287-F1295
Aldosterone is thought to modulate renal fibrosis, in part, through increasing plasminogen activator inhibitor type 1 (PAI-1), a major inhibitor of ECM degradation. The present study investigated aldosterone effects on PAI-1 and transforming growth f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8e46119779508faa4db3800c938fb8
https://doi.org/10.1152/ajprenal.00017.2008
https://doi.org/10.1152/ajprenal.00017.2008
Publikováno v:
Journal of the American Society of Nephrology. 19:329-338
Plasminogen activator inhibitor-1 (PAI-1) has been implicated in renal fibrosis. In vitro, PAI-1 inhibits plasmin generation, and this decreases mesangial extracellular matrix turnover. PAI-1R, a mutant PAI-1, increases glomerular plasmin generation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8356f21d2f4a24d4363d8d2ac9eed4a
https://doi.org/10.1681/asn.2007040510
https://doi.org/10.1681/asn.2007040510
Publikováno v:
Kidney International. 72:45-52
Recent evidence indicates that renin itself might be profibrotic, independent of angiotensin II; however, the signaling system by which renin exerts a direct effect is not known. We tested the hypothesis that renin receptor activation, in turn, activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20fdcbcea916ac3711c1fdfbd70a3e0
https://doi.org/10.1038/sj.ki.5002243
https://doi.org/10.1038/sj.ki.5002243
Autor:
D. McQuillan, Wayne A. Border, Yufeng Huang, Ling Yu, S. Wongamorntham, J. Kasting, Nancy A. Noble, R.T. Owens
Publikováno v:
Kidney International. 69(1):105-113
Recent evidence suggesting a strong interplay between components of the renin-angiotensin system and key mediators of fibrosis led us to hypothesize that renin, independent of its enzymatic action to enhance angiotensin (Ang) II synthesis, directly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97266e5e5f42d9070f96fe642c3dadb9
Publikováno v:
Kidney International. 68(5):2042-2049
Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through upregulation of heme oxygenase 1 . Background Induction of heme oxygenase 1 (HO-1) has been shown to be beneficial in a variety of pathologic settings. Curcumin, a polyphenolic compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bcc78ea37cdf8306c92b3396c89669