Výsledky vyhledávání - "Wauters, Armelle"

Additional file 8: Figure S8. of Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

Autor: Vanderplanck, Céline, Tassin, Alexandra, Ansseau, Eugénie, Charron, Sébastien, Wauters, Armelle, Lancelot, Céline, Vancutsem, Kelly, Laoudj-Chenivesse, Dalila, Belayew, Alexandra, Coppée, Frédérique

DUX4c inhibition in myoblasts decreases mitosis. DUX4c inhibition causes cell proliferation defects. FSHD and control primary myoblasts were transfected with siRNAs targeting either the DUX4 or DUX4c mRNA or a non-targeted (nt) siRNA. Top: microscope

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Additional file 9: Table S1. of Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

Cytoskeleton-associated protein quantification in healthy and FSHD myotubes : reorganization of the proteomic data presented separately in Tassin et al (2012: Figure 3, supplemental tables; and unpublished data). Data were subdivided in the three cla

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Additional file 4: Figure S4. of Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

dFSHD myotubes present abnormal clusters of nuclei overexpressing DUX4c, cytoplasmic DUX4c, and α-tubulin as well as α-crystallin B chain delocalization. A. Healthy and FSHD primary myoblasts were differentiated and fixed 6 days later, and DUX4c (r

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Additional file 11: Figure S10. of Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

DUX4 myogenic enhancer (DME1 and 2) might interact with the DUX4c gene. The DUX4 forward primer used in a 3C capture experiment [79] is highlighted in a common region in DUX4 and DUX4c ORF sharing 100% identity (Accession numbers AF AF117653 and AY50

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Additional file 5: Figure S5. of Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

DUX4c overexpression induces expression of FSHD markers. FSHD and healthy primary myoblasts were transfected with the indicated pCIneo expression vectors. A. Total protein extracts were prepared 48 h after transfection. A 30 μg sample of each extrac

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Additional file 6: Figure S6. of Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

DUX4c siRNA design and efficiency evaluation. A. Schematic representation of the DUX4c 3′UTR (positions from Genbank accession number AY500824). The STOP codon, two purine-rich regions which could be used as an alternative 3′end processing (as sh

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Additional file 3: Figure S3. of Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

DUX4c overexpression induces β-catenin. Healthy primary myoblasts were transfected with pAC1M2-DUX4c and differentiated 48 h later. After the first myotubes formed (day 3), DUX4c expression was induced by the addition of 100 ng or 1 μg of doxycycli

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Additional file 2: Figure S2. of Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

DUX4c overexpression induces the formation of ring-like clusters of nuclei and detection of DUX4c in nuclei and the cytoplasm. Healthy primary myoblasts were transfected with pAC1M2-DUX4c and differentiated 48 h later. After formation of the first my

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