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Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus

Autor: Debenedette, M. A., Wen, T., Bachmann, M. F., Pamela S. Ohashi, Barber, B. H., Stocking, K. L., Peschon, J. J., Watts, T. H.

Publikováno v: Scopus-Elsevier

4-1BB ligand (4-1BBL) is a member of the TNF family expressed on activated APC. 4-1BBL binds to 4-1BB (CD137) on activated CD4 and CD8 T cells and in conjunction with strong signals through the TCR provides a CD28-independent costimulatory signal lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bb930c9f6f3709d15f2bf0e1f123b8
https://doi.org/10.4049/jimmunol.163.9.4833

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Characterization of the signaling function of MHC class II molecules during antigen presentation by B cells

Autor: Yves St-Pierre, Watts, T. H.

Publikováno v: Scopus-Elsevier

In addition to their role as peptide binding proteins, MHC class II proteins can also function as signal transducing molecules. Recent work using B cells expressing genetically engineered truncated MHC class II molecules has suggested that signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e5183c19d9ccc9c59bf47a3e04bb16
https://doi.org/10.4049/jimmunol.147.9.2875

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Akademický článek

Biophysical Aspects of Antigen Recognition by T Cells.

Autor: Watts, T H, McConnell, H M

Publikováno v: Annual Review of Immunology; Apr1987, Vol. 5 Issue 1, p461-475, 15p

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Akademický článek

Tumor Microenvironment Drives the Cross-Talk Between Co-Stimulatory and Inhibitory Molecules in Tumor-Infiltrating Lymphocytes: Implications for Optimizing Immunotherapy Outcomes.

Autor: Franzese, Ornella

Publikováno v: International Journal of Molecular Sciences; Dec2024, Vol. 25 Issue 23, p12848, 41p

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MicroRNA-22 Regulates the Pro-inflammatory Responses and M1 Polarization of Macrophages by Targeting GLUT1 and 4-1BBL.

Autor: Kang, Young Jun¹ (AUTHOR)

Publikováno v: Journal of Immunology Research. 7/10/2023, p1-12. 12p. 5 Graphs.

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Short-Term Effect of Continuous Subcutaneous Insulin Infusion and Multiple Daily Injection in Perioperative Patients with Type 2 Diabetes Mellitus.

Autor: Song, Wei¹ (AUTHOR), Wen, Jianxuan¹ (AUTHOR), Zhang, Jinming¹ (AUTHOR), Luo, Meng² (AUTHOR), Hu, Yue³ (AUTHOR), Zhang, Yu³ (AUTHOR), Fan, Guanjie¹ (AUTHOR), Zhao, Ling¹ (AUTHOR)

Publikováno v: Journal of Diabetes Research. 6/23/2023, p1-6. 6p.

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Akademický článek

Enhanced insulin‐regulated phagocytic activities support extreme health span and longevity in multiple populations.

Autor: Wu, Deng¹ (AUTHOR), Bi, Xiaoman^2,3 (AUTHOR), Li, Peihu² (AUTHOR), Xu, Dahua² (AUTHOR), Qiu, Jianmin³ (AUTHOR), Li, Kongning² (AUTHOR) likongning@hainmc.edu.cn, Zheng, Shaojiang³ (AUTHOR) zhengshaojiang@hainmc.edu.cn, Chow, Kim Hei‐Man¹ (AUTHOR) heimanchow@cuhk.edu.hk

Publikováno v: Aging Cell. May2023, Vol. 22 Issue 5, p1-19. 19p.

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Periodical

Antigen presentation by supported planar membranes containing affinity-purified I-Ad.

Autor: Watts, T H, Brian, A A, Kappler, J W, Marrack, P, McConnell, H M

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; December 1984, Vol. 81 Issue: 23 p7564-7568, 5p

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