Zobrazeno 1 - 10
of 363
pro vyhledávání: '"Watt Pc"'
Autor:
Rubio CA; Department of Oncology and Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden., Lang-Schwarz C; Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Klinikum Bayreuth, Bayreuth, Germany., Vieth M; Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Klinikum Bayreuth, Bayreuth, Germany.
Publikováno v:
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2024 Dec; Vol. 39 (12), pp. 2479-2486. Date of Electronic Publication: 2024 Nov 10.
Autor:
John H. Walsh, Stefan Moldovan, Watt Pc, Robert Kleinman, Thu-Ha Nguyen, Francis C. Brunicardi, Ronald L. Gingerich
Publikováno v:
Pancreas. 23:302-308
Introduction In this study, immunoneutralization of endogenous insulin, glucagon, and somatostatin with specific antibodies was used in an isolated perfused human pancreas (IPHP) model. Aims To study intrapancreatic cellular interactions and pancreat
Autor:
Francis C. Brunicardi, Yoko Mullen, Watanabe Y, Elizabeth A. Stein, Watt Pc, Nomura Y, Hober C, Pierre Y. Benhamou
Publikováno v:
Pancreas. 14:199-204
Summary The availability of highly purified human islets has increased with the progressive improvement of isolation methods. This has provided opportunities to perform various in vitro studies on human islets. However, when islets are maintained in
Autor:
Watt Pc, Yoko Mullen, Robert Kleinman, Edward Passaro, Satoshi Une, Seiji Arita, Peter G. Stock, Pierre Y. Benhamou, Takashi Kenmochi, Yoshi Wantanabe, L Shevlin, Yasu Nomura, F. Charles Brunicardi, Thomas J. Rosenthal, S. Ohtsuka, A. Atiya, Ronald W. Busuttil, Masaaki Miyamato
Publikováno v:
Surgery. 118:967-972
Background. The University of California Islet Transplant Consortium was formed to evaluate the feasibility of performing clinical islet transplantation at different transplant centers by using a single centralized islet isolation laboratory. Methods
Autor:
Watt Pc, Watanabe Y, Pierre Y. Benhamou, Takashi Kenmochi, Nomura Y, Yoko Mullen, Brunicardi Fc, Elizabeth Stein, Masaaki Miyamoto, Christine Hober
Publikováno v:
Hormone and Metabolic Research. 27:113-120
Allograft rejection is the major cause for failure in clinical islet transplantation for diabetic patients. A reduction of donor islet immunogenicity is potentially a useful approach for altering recipient's immune responses. Studies in animal models
Autor:
Christopher D. Anderson, Nomura Y, Watt Pc, Brunicardi Fc, Watanabe Y, Edward Passaro, Yoko Mullen, Michael J. Zinner
Publikováno v:
Journal of Surgical Research. 56:367-371
Work in rodents has shown that injection of pancreatic islets of Langerhans into the thymus can induce donor-specific unresponsiveness to islets subsequently transplanted to extrathymic sites. The overall objective of our investigation is to test thi
Autor:
Yoko Mullen, Ryozo Moriuchi, M. Watanabe, Shoichi Akazawa, Tsutomu Miyamoto, T. Yamaguchi, Brunicardi Fc, Watt Pc, S Nagataki, K. Saitoh, Eiji Kawasaki
Publikováno v:
Biochemical and Biophysical Research Communications. 192:1353-1359
Glutamic acid decarboxylase (GAD) catalyzes formation of γ-aminobutyric acid from glutamic acid and is a major autoantigen in insulin-dependent diabetes mellitus. Its two isoforms, GAD65 and GAD67, are encoded by two separate genes. We prepared huma
Autor:
Catia Sternini, Vay Liang W. Go, Howard Wong, Karl Anderson, J.H. Walsh, Watt Pc, R. De Giorgio, Howard A. Reber, A. L. Widdison, F. C. Brunicardi
Publikováno v:
Cell and Tissue Research. 269:447-458
In the pancreas, calcitonin gene-related peptide (CGRP) immunoreactivity has been described in nerve fibers and in distinct types of islet cells. This unique, apparently species-specific cell-type expression prompted the present investigation to clar
Publikováno v:
Pancreas. 9(2)
This study was undertaken to determine whether intraislet somatostatin inhibits insulin secretion in the human islet. A high-affinity monoclonal somatostatin antibody was used to immunoneutralize somatostatin in the isolated, perfused human pancreas.
Publikováno v:
American journal of surgery. 165(3)
The ability to transfer genetic material from one cell to another provides a novel approach for the investigation and potential treatment of a variety of diseases. Several gene transfer techniques have been developed. Of these, the use of retroviruse