Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons

Autor: Watson, P. Marc D., Humphries, Martin J., Relton, Jane, Rothwell, Nancy J., Verkhratsky, Alex, Gibson, Rosemary M.

Publikováno v: In Molecular and Cellular Neuroscience 2007 34(2):147-154

Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier.

Autor: Watson, P. Marc D.¹ watsonm@medimmune.com, Paterson, Judy C.¹, Thom, George¹, Ginman, Ulrika², Lundquist, Stefan², Webster, Carl I.¹

Publikováno v: BMC Neuroscience. 2013, Vol. 14 Issue 1, p1-21. 21p. 2 Color Photographs, 1 Black and White Photograph, 4 Charts, 5 Graphs.

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

Autor: Hall, Claire E, Yao, Zhi, Choi, Minee, Tyzack, Giulia E, Serio, Andrea, Luisier, Raphaelle, Harley, Jasmine, Preza, Elisavet, Arber, Charlie, Crisp, Sarah J, Watson, P Marc D, Kullmann, Dimitri M, Abramov, Andrey Y, Wray, Selina, Burley, Russell, Loh, Samantha HY, Martins, L Miguel, Stevens, Molly M, Luscombe, Nicholas M, Sibley, Christopher R, Lakatos, Andras, Ule, Jernej, Gandhi, Sonia, Patani, Rickie

Publikováno v: Cell Reports
Cell Reports, Vol 19, Iss 9, Pp 1739-1749 (2017)
Hall, C E, Yao, Z, Choi, M, Tyzack, G E, Serio, A, Luisier, R, Harely, J, Preza, E, Arber, C, Crisp, S J, Watson, P M D, Kullmann, D, Abramov, A, Wray, S, Burley, R, Loh, S HY, Martins, M, Stevens, M, Luscombe, N M, Sibley, C R, Lakatos, A, Ule, J, Gandhi, S & Patani, R 2017, ' Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS ', Cell Reports, vol. 19, no. 9, pp. 1739-1749 . https://doi.org/10.1016/j.celrep.2017.05.024
Hall, C E, Yao, Z, Choi, M, Tyzack, G E, Serio, A, Luisier, R, Harley, J, Preza, E, Arber, C, Crisp, S J, Watson, P M D, Kullmann, D M, Abramov, A Y, Wray, S, Burley, R, Loh, S H Y, Martins, L M, Stevens, M M, Luscombe, N M, Sibley, C R, Lakatos, A, Ule, J, Gandhi, S & Patani, R 2017, ' Progressive motor neuron pathology and the role of astrocytes in a Human Stem Cell Model of VCP-Related ALS ', Cell Reports, vol. 19, no. 9, pp. 1739-1749 . https://doi.org/10.1016/j.celrep.2017.05.024

Summary Motor neurons (MNs) and astrocytes (ACs) are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but their interaction and the sequence of molecular events leading to MN death remain unresolved. Here, we optimized directed

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