A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice.

Autor: Cao S; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA. sjcao@uw.edu.; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA, USA. sjcao@uw.edu., Budina E; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Raczy MM; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Solanki A; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.; Animal Resource Center, University of Chicago, Chicago, IL, USA., Nguyen M; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.; Animal Resource Center, University of Chicago, Chicago, IL, USA., Beckman TN; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Reda JW; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Hultgren K; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Ang PS; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Slezak AJ; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Hesser LA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Alpar AT; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Refvik KC; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Shores LS; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Pillai I; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Wallace RP; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Dhar A; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Watkins EA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Hubbell JA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA. jhubbell@uchicago.edu.; Committee on Immunology, University of Chicago, Chicago, IL, USA. jhubbell@uchicago.edu.; Committee on Cancer Biology, University of Chicago, Chicago, IL, USA. jhubbell@uchicago.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2024 May; Vol. 8 (5), pp. 611-627. Date of Electronic Publication: 2024 Apr 01.

Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics.

Autor: Wallace RP; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Refvik KC; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Antane JT; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Brünggel K; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Tremain AC; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Raczy MR; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Alpar AT; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Nguyen M; Animal Resources Center, University of Chicago, Chicago, IL 60637, USA., Solanki A; Animal Resources Center, University of Chicago, Chicago, IL 60637, USA., Slezak AJ; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Watkins EA; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Lauterbach AL; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Cao S; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Wilson DS; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Biomedical Engineering Department, Johns Hopkins University, Baltimore, MD 21211, USA. Electronic address: scott.wilson@jhmi.edu., Hubbell JA; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA; Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA. Electronic address: jhubbell@uchicago.edu.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Jan 16; Vol. 5 (1), pp. 101345. Date of Electronic Publication: 2023 Dec 20.

Adipose Stem Cell Microbeads as Production Sources for Chondrogenic Growth Factors

Autor: Lee CSD, Nicolini AM, Watkins EA, Burnsed OA, Boyan BD, Schwartz Z

Publikováno v: Journal of Stem Cells and Regenerative Medicine, Vol 10, Iss 2, Pp 38-48 (2014)

Microencapsulating stem cells in injectable microbeads can enhance delivery and localization, but their ability to act as growth factor production sources is still unknown. To address this concern, growth factor mRNA levels and production from algina

Externí odkaz: https://doaj.org/article/dc68ac1be8044161aa5819d3e1d545da

Mannose-Decorated Co-Polymer Facilitates Controlled Release of Butyrate to Accelerate Chronic Wound Healing.

Autor: Lauterbach AL; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA., Slezak AJ; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA., Wang R; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA., Cao S; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA., Raczy MM; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA., Watkins EA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA., Jimenez CJM; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA., Hubbell JA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA.

Publikováno v: Advanced healthcare materials [Adv Healthc Mater] 2023 Oct; Vol. 12 (26), pp. e2300515. Date of Electronic Publication: 2023 Aug 22.

Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses.

Autor: Tremain AC; Committee on Immunology, University of Chicago, Chicago, IL, USA., Wallace RP; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA., Lorentz KM; Anokion US Inc., Cambridge, MA, USA., Thornley TB; Anokion US Inc., Cambridge, MA, USA., Antane JT; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA., Raczy MR; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA., Reda JW; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA., Alpar AT; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA., Slezak AJ; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA., Watkins EA; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA., Maulloo CD; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA., Budina E; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA., Solanki A; Animal Resources Center, University of Chicago, Chicago, IL, USA., Nguyen M; Animal Resources Center, University of Chicago, Chicago, IL, USA., Bischoff DJ; Anokion US Inc., Cambridge, MA, USA., Harrington JL; Anokion US Inc., Cambridge, MA, USA., Mishra R; Anokion US Inc., Cambridge, MA, USA., Conley GP; Anokion US Inc., Cambridge, MA, USA., Marlin R; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France., Dereuddre-Bosquet N; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France., Gallouët AS; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France., LeGrand R; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France., Wilson DS; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA. scott.wilson@jhmi.edu.; Biomedical Engineering Department, Johns Hopkins University, Baltimore, MD, USA. scott.wilson@jhmi.edu., Kontos S; Anokion US Inc., Cambridge, MA, USA., Hubbell JA; Committee on Immunology, University of Chicago, Chicago, IL, USA. jhubbell@uchicago.edu.; Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA. jhubbell@uchicago.edu.; Committee on Cancer Biology, University of Chicago, Chicago, IL, USA. jhubbell@uchicago.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2023 Sep; Vol. 7 (9), pp. 1142-1155. Date of Electronic Publication: 2023 Sep 07.