Longitudinal analyses reveal immunological misfiring in severe COVID-19

Autor: Lucas, Carolina, Wong, Patrick, Klein, Jon, Castro, Tiago B. R., Silva, Julio, Sundaram, Maria, Ellingson, Mallory K., Mao, Tianyang, Oh, Ji Eun, Israelow, Benjamin, Takahashi, Takehiro, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Mohanty, Subhasis, Wang, Haowei, Wyllie, Anne L., Vogels, Chantal B. F., Earnest, Rebecca, Lapidus, Sarah, Ott, Isabel M., Moore, Adam J., Muenker, M. Catherine, Fournier, John B., Campbell, Melissa, Odio, Camila D., Casanovas-Massana, Arnau, Obaid, Abeer, Lu-Culligan, Alice, Nelson, Allison, Brito, Anderson, Nunez, Angela, Martin, Anjelica, Watkins, Annie, Geng, Bertie, Kalinich, Chaney, Harden, Christina, Todeasa, Codruta, Jensen, Cole, Kim, Daniel, McDonald, David, Shepard, Denise, Courchaine, Edward, White, Elizabeth B., Song, Eric, Silva, Erin, Kudo, Eriko, DeIuliis, Giuseppe, Rahming, Harold, Park, Hong-Jai, Matos, Irene, Nouws, Jessica, Valdez, Jordan, Fauver, Joseph, Lim, Joseph, Rose, Kadi-Ann, Anastasio, Kelly, Brower, Kristina, Glick, Laura, Sharma, Lokesh, Sewanan, Lorenzo, Knaggs, Lynda, Minasyan, Maksym, Batsu, Maria, Petrone, Mary, Kuang, Maxine, Nakahata, Maura, Linehan, Melissa, Askenase, Michael H., Simonov, Michael, Smolgovsky, Mikhail, Sonnert, Nicole, Naushad, Nida, Vijayakumar, Pavithra, Martinello, Rick, Datta, Rupak, Handoko, Ryan, Bermejo, Santos, Prophet, Sarah, Bickerton, Sean, Velazquez, Sofia, Alpert, Tara, Rice, Tyler, Khoury-Hanold, William, Peng, Xiaohua, Yang, Yexin, Cao, Yiyun, Strong, Yvette, Herbst, Roy, Shaw, Albert C., Medzhitov, Ruslan, Schulz, Wade L., Grubaugh, Nathan D., Dela Cruz, Charles, Farhadian, Shelli, Ko, Albert I., Omer, Saad B., Iwasaki, Akiko

Publikováno v: Nature

Recent studies have provided insights into the pathogenesis of coronavirus disease 2019 (COVID-19)1–4. However, the longitudinal immunological correlates of disease outcome remain unclear. Here we serially analysed immune responses in 113 patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ff8e93575221c1b5194b71c8befa64

Saliva viral load is a dynamic unifying correlate of COVID-19 severity and mortality.

Autor: Silva J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Lucas C; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Sundaram M; ICES, Toronto, ON, Canada.; University of Toronto Dalla Lana School of Public Health, Toronto, ON, Canada., Israelow B; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA., Wong P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Klein J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Tokuyama M; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Lu P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Venkataraman A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Liu F; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Mao T; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Oh JE; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Park A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Casanovas-Massana A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Vogels CBF; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Muenker MC; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Zell J; Department of Medicine, Section of Pulmonary and Critical Care Medicine; Yale University School of Medicine, New Haven, CT, USA., Fournier JB; Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA., Campbell M; Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA., Chiorazzi M; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Fuentes ER; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Petrone ME; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Kalinich CC; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Ott IM; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Watkins A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Moore AJ; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Nakahata M; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Farhadian S; Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA., Cruz CD; Department of Medicine, Section of Pulmonary and Critical Care Medicine; Yale University School of Medicine, New Haven, CT, USA., Ko AI; Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Schulz WL; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.; Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT, USA., Ring A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Ma S; Department of Biostatistics, Yale University, New Haven, Connecticut, USA., Omer S; Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.; Yale Institute for Global Health, Yale University, New Haven, CT, USA., Wyllie AL; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Iwasaki A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2021 Jan 10. Date of Electronic Publication: 2021 Jan 10.