Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins.

Autor: Fallon TR; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and University of California, San Diego, La Jolla, CA 92093, USA., Shende VV; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and University of California, San Diego, La Jolla, CA 92093, USA., Wierzbicki IH; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA., Pendleton AL; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.; Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907, USA., Watervoort NF; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.; Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907, USA., Auber RP; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.; Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907, USA., Gonzalez DJ; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Wisecaver JH; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.; Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907, USA., Moore BS; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and University of California, San Diego, La Jolla, CA 92093, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Aug 09; Vol. 385 (6709), pp. 671-678. Date of Electronic Publication: 2024 Aug 08.