Proximal fleximer analogues of 2'-deoxy-2'-fluoro-2'-methyl purine nucleos(t)ides: Synthesis and preliminary pharmacokinetic and antiviral evaluation.

Autor: Waters CD 3rd; Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA., Carlyle E; Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA., Smart V; Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA., Rege A; Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA., Bieberich CJ; Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA., Seley-Radtke KL; Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA. Electronic address: kseley@umbc.edu.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Oct 01; Vol. 112, pp. 117898. Date of Electronic Publication: 2024 Aug 24.

Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro.

Autor: Thames JE; Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA., Waters CD 3rd; Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA., Valle C; AFMB-UMR7257, CNRS, Aix Marseille University, Marseille, France., Bassetto M; Department of Chemistry, College of Science, Swansea University, Swansea, UK., Aouadi W; AFMB-UMR7257, CNRS, Aix Marseille University, Marseille, France., Martin B; AFMB-UMR7257, CNRS, Aix Marseille University, Marseille, France., Selisko B; AFMB-UMR7257, CNRS, Aix Marseille University, Marseille, France., Falat A; Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA., Coutard B; Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France., Brancale A; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK., Canard B; AFMB-UMR7257, CNRS, Aix Marseille University, Marseille, France., Decroly E; AFMB-UMR7257, CNRS, Aix Marseille University, Marseille, France., Seley-Radtke KL; Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA. Electronic address: kseley@umbc.edu.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Nov 15; Vol. 28 (22), pp. 115713. Date of Electronic Publication: 2020 Aug 31.