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Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells.

Autor: Béquignon OJM; Leiden Academic Centre for Drug Research, Leiden University, Wassenaarseweg 76, 2333 AL Leiden, The Netherlands., Gómez-Tamayo JC; Research Programme on Biomedical Informatics (GRIB), Department of Medicine and Life Sciences, Hospital del Mar Medical Research Institute, Universitat Pompeu Fabra, Carrer del Dr. Aiguader 88, 08002 Barcelona, Spain., Lenselink EB; Leiden Academic Centre for Drug Research, Leiden University, Wassenaarseweg 76, 2333 AL Leiden, The Netherlands., Wink S; Leiden Academic Centre for Drug Research, Leiden University, Wassenaarseweg 76, 2333 AL Leiden, The Netherlands., Hiemstra S; Leiden Academic Centre for Drug Research, Leiden University, Wassenaarseweg 76, 2333 AL Leiden, The Netherlands., Lam CC; Leiden Academic Centre for Drug Research, Leiden University, Wassenaarseweg 76, 2333 AL Leiden, The Netherlands., Gadaleta D; Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences, IRCCS─Istituto di Ricerche Farmacologiche Mario Negri, Via la Masa 19, 20156 Milano, Italy., Roncaglioni A; Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences, IRCCS─Istituto di Ricerche Farmacologiche Mario Negri, Via la Masa 19, 20156 Milano, Italy., Norinder U; MTM Research Centre, School of Science and Technology, Örebro University, SE-70182 Örebro, Sweden., Water BV; Leiden Academic Centre for Drug Research, Leiden University, Wassenaarseweg 76, 2333 AL Leiden, The Netherlands., Pastor M; Research Programme on Biomedical Informatics (GRIB), Department of Medicine and Life Sciences, Hospital del Mar Medical Research Institute, Universitat Pompeu Fabra, Carrer del Dr. Aiguader 88, 08002 Barcelona, Spain., van Westen GJP; Leiden Academic Centre for Drug Research, Leiden University, Wassenaarseweg 76, 2333 AL Leiden, The Netherlands.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2023 Sep 11; Vol. 63 (17), pp. 5433-5445. Date of Electronic Publication: 2023 Aug 24.

Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival.

Autor: Nair NU; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, 20742, USA.; Cancer Data Science Lab, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, USA., Das A; Department of Biostatistics and Computational Biology, Harvard School of Public Health, Boston, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA., Rogkoti VM; Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands., Fokkelman M; Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands., Marcotte R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.; National Research Council Canada, Montreal, Canada., de Jong CG; Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands., Koedoot E; Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands., Lee JS; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, 20742, USA.; Cancer Data Science Lab, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, USA., Meilijson I; Department of Statistics and Operations Research, School of Mathematical Sciences, Tel Aviv University, Tel Aviv, 69978, Israel., Hannenhalli S; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, 20742, USA., Neel BG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.; Laura and Isaac Perlmutter Cancer Centre, NYU-Langone Medical Center, New York City, NY, 10016, USA.; Alexandria Center for Life Science, New York, NY, 10016, USA., de Water BV; Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands., Le Dévédec SE; Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands., Ruppin E; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, 20742, USA. eytan.ruppin@nih.gov.; Cancer Data Science Lab, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, USA. eytan.ruppin@nih.gov.; The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, 69978, Israel. eytan.ruppin@nih.gov.

Publikováno v: Scientific reports [Sci Rep] 2019 Jul 29; Vol. 9 (1), pp. 10989. Date of Electronic Publication: 2019 Jul 29.

A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen.

Autor: Driessen M; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Division of Toxicology, Leiden/Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands. Electronic address: marja.driessen@embl.de., Vitins AP; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Department of Toxicogenomics, Maastricht University, 6200 MD Maastricht, The Netherlands., Pennings JL; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands., Kienhuis AS; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands., Water Bv; Division of Toxicology, Leiden/Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., van der Ven LT; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands.

Publikováno v: Toxicology letters [Toxicol Lett] 2015 Jan 22; Vol. 232 (2), pp. 403-12. Date of Electronic Publication: 2014 Nov 24.

Aerobic granular sludge technology: an alternative to activated sludge?

Autor: de Bruin LM; DHV Water BV, AL Amersfoort, The Netherlands. bart.debruin@dhv.nl, de Kreuk MK, van der Roest HF, Uijterlinde C, van Loosdrecht MC

Publikováno v: Water science and technology : a journal of the International Association on Water Pollution Research [Water Sci Technol] 2004; Vol. 49 (11-12), pp. 1-7.