Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Wataru Suto"'
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202623 (2018)
RATIONALE:Augmented smooth muscle contractility of the airways is one of the causes of airway hyperresponsiveness in asthmatics. However, the mechanism of the altered properties of airway smooth muscle cells is not well understood. OBJECTIVES:To iden
Externí odkaz:
https://doaj.org/article/a37d0ff21a2c4a5c9651600ec14feb24
Autor:
Wataru Suto, Yusuke Ando, Takahiro Hirabayashi, Fumiko Takenoya, Seiji Shioda, Junzo Kamei, Hiroyasu Sakai, Yoshihiko Chiba
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3036 (2018)
Prostaglandin D2 (PGD2) is one of the key lipid mediators of allergic airway inflammation, including bronchial asthma. However, the role of PGD2 in the pathogenesis of asthma is not fully understood. In the present study, the effect of PGD2 on smooth
Externí odkaz:
https://doaj.org/article/2de46d58b99e40a884875ff489315a4c
Publikováno v:
Lung. 200(5)
Extracellular acidification is a major component of tissue inflammation, including airway inflammation. The extracellular proton-sensing mechanisms are inherent in various cells including airway structural cells, although their physiological and path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a993c97e54086d8a90a73a134ce4f1
https://pubmed.ncbi.nlm.nih.gov/35930050
https://pubmed.ncbi.nlm.nih.gov/35930050
Autor:
Yusuke Ando, Seiji Shioda, Junzo Kamei, Takahiro Hirabayashi, Ichiro Takasaki, Chihiro Ueda, Yoshihiko Chiba, Wataru Suto, Fumiko Takenoya, Hiroyasu Sakai, Michio Yamashita, Naoko Kohno, Yui Miyakawa
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 319:L786-L793
Bronchomotor tone is regulated by contraction and relaxation of airway smooth muscle (ASM). A weakened ASM relaxation might be a cause of airway hyperresponsiveness (AHR), a characteristic feature of bronchial asthma. Pituitary adenylyl cyclase-activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e57b8829d5bbbb82bffcb12b7d0a2a5
https://doi.org/10.1152/ajplung.00315.2020
https://doi.org/10.1152/ajplung.00315.2020
Autor:
Yoshihiko, Chiba, Yukika, Adachi, Yusuke, Ando, Shigeki, Fujii, Wataru, Suto, Hiroyasu, Sakai
Publikováno v:
Life Sciences. 313:121289
Augmented smooth muscle contractility of the airways associated with an increased expression of RhoA, a monomeric GTPase responsible for CaCultured human BSM cells were transfected with MALAT1 antisense oligonucleotide (AS), miR-133a-3p mimic, and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebee5d7540082013ac53be786f54aaca
https://doi.org/10.1016/j.lfs.2022.121289
https://doi.org/10.1016/j.lfs.2022.121289
Autor:
Yoshihiko Chiba, Yui Miyakawa, Shigeki Fujii, Junzo Kamei, Motohiko Hanazaki, Hiroyasu Sakai, Yusuke Ando, Wataru Suto
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 64:138-140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada0f53207326f2c0b5a738bc1fcc4a8
https://doi.org/10.1165/rcmb.2020-0292le
https://doi.org/10.1165/rcmb.2020-0292le
Publikováno v:
Journal of Smooth Muscle Research. 55:1-13
Prostaglandin D2 (PGD2), one of the key lipid mediators of allergic airway inflammation, is increased in the airways of asthmatics. However, the role of PGD2 in the pathogenesis of asthma is not fully understood. In the present study, effects of PGD2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff8b5edf82bbebb9bd24a705a5389db1
https://doi.org/10.1540/jsmr.55.1
https://doi.org/10.1540/jsmr.55.1
Autor:
Masafumi Takahashi, Masatoshi Hori, Wataru Suto, Yoshihiko Chiba, Yuki Kai, Fumitake Usui-Kawanishi, Lin Hai Kurahara, Keizo Hiraishi, Hiroyasu Sakai, Ryuji Inoue
Publikováno v:
Journal of Smooth Muscle Research
In the past few decades, solid evidence has been accumulated for the pivotal significance of immunoinflammatory processes in the initiation, progression, and exacerbation of many diseases and disorders. This groundbreaking view came from original wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1791e6ecb7a3237bc3ed9b3f333cae20
https://doi.org/10.1540/jsmr.55.81
https://doi.org/10.1540/jsmr.55.81
Autor:
Kaori Okumura, Hiroyasu Sakai, Sayuri Tamaki, Wataru Suto, Yoshihiko Chiba, Motohiko Hanazaki, Yurika Yasuhara
Publikováno v:
Respiratory physiologyneurobiology. 289
Purpose Augmented bronchial smooth muscle (BSM) contraction is a cause of airway hyperresponsiveness (AHR) in asthma. Increasing evidence suggest that C-C motif chemokine 2 (CCL2) modulates smooth muscle contractility by activating its binding partne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67e619e15bcb72f27af960bfb612a4b
https://pubmed.ncbi.nlm.nih.gov/33813049
https://pubmed.ncbi.nlm.nih.gov/33813049
Autor:
Yamato Yamane, Yoshihiko Chiba, Shunta Danno, Motohiko Hanazaki, Wataru Suto, Hiroyasu Sakai, Rena Suto, Hiroshi Katayama
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 314:L215-L223
Progranulin (PGRN) is a growth factor with multiple biological functions and has been suggested as an endogenous inhibitor of Tumor necrosis factor-α (TNF-α)-mediated signaling. TNF-α is believed to be one of the important mediators of the pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd835a1021c172b16a662d674760110e
https://doi.org/10.1152/ajplung.00575.2016
https://doi.org/10.1152/ajplung.00575.2016