Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Wataru Otsu"'
Autor:
Cheng Fu, Nan Yang, Jen-Zen Chuang, Nobuyuki Nakajima, Satoshi Iraha, Neeta Roy, Zhenquan Wu, Zhichun Jiang, Wataru Otsu, Roxana A. Radu, Howard Hua Yang, Maxwell Ping Lee, Tilla S. Worgall, Wen-Cheng Xiong, Ching-Hwa Sung
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Vacuolar protein sorting 35 (VPS35), the core component of the retromer complex which regulates endosomal trafficking, is genetically linked with Parkinson’s disease (PD). Impaired vision is a common non-motor manifestation of PD. Here, we
Externí odkaz:
https://doaj.org/article/6795212de22b42e1b120beca529a58fb
Autor:
Kanta Yamazaki, Kodai Ishida, Wataru Otsu, Aomi Muramatsu, Shinsuke Nakamura, Wakana Yamada, Hideshi Tsusaki, Hiroshi Shimoda, Hideaki Hara, Masamitsu Shimazawa
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Blue light exposure is known to induce reactive oxygen species (ROS) production and increased endoplasmic reticulum stress, leading to apoptosis of photoreceptors. Maqui berry (Aristotelia chilensis) is a fruit enriched in anthocy
Externí odkaz:
https://doaj.org/article/d865dad8afd8404b82ffe56ad659dd73
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/f3d8e8a0033b4b6ebe156d7a8f7a6d04
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The primary cilium is a single immotile microtubule-based organelle that protrudes into the extracellular space. Malformations and dysfunctions of the cilia have been associated with various forms of syndromic and non-syndromic diseases, termed cilio
Externí odkaz:
https://doaj.org/article/7cb412cfa1ad4ad48467e190bf4009a2
Autor:
Wataru Otsu, Tomohiro Yako, Emi Sugisawa, Shinsuke Nakamura, Hideshi Tsusaki, Naofumi Umigai, Masamitsu Shimazawa, Hideaki Hara
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 4, Pp 279-288 (2022)
The corneal epithelium is located at the outermost layer of the ocular surface and continuously exposed to environmental factors, such as ultraviolet (UV) radiation from sunlight. UV irradiation causes excessive production of reactive oxygen species
Externí odkaz:
https://doaj.org/article/ebe40e94454f4839a05ac87daad2912d
Autor:
Wataru Otsu, Naoki Chinen, Emi Sugisawa, Haru Kitano, Shinsuke Nakamura, Naofumi Umigai, Hideshi Tsusaki, Masamitsu Shimazawa
Publikováno v:
Journal of Functional Foods, Vol 106, Iss , Pp 105611- (2023)
Tobacco smoke contains many toxic chemicals, such as highly unstable free radicals, reactive oxygen species, and carbonyl compounds such as acrolein. Crocetin, a natural carotenoid found in plants, has various biological properties, including antioxi
Externí odkaz:
https://doaj.org/article/e97c947ccec24118a02be51149ea0696
Autor:
Jen-Zen Chuang, Nan Yang, Nobuyuki Nakajima, Wataru Otsu, Cheng Fu, Howard Hua Yang, Maxwell Ping Lee, Armaan Fazal Akbar, Tudor Constantin Badea, Ziqi Guo, Afnan Nuruzzaman, Kuo-Shun Hsu, Joshua L. Dunaief, Ching-Hwa Sung
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Age-related macular degeneration (AMD) is a leading cause of blindness and is characterised by the accumulation of lipid deposits, called drusen. Here, the authors show that mice lacking chloride intracellular channel 4 in retinal pigment epithelium
Externí odkaz:
https://doaj.org/article/6225ad8d8100460da61f269eb1c4addd
Autor:
Wataru Otsu, Kodai Ishida, Naoki Chinen, Shinsuke Nakamura, Masamitsu Shimazawa, Hideshi Tsusaki, Hideaki Hara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The cornea is directly exposed to cigarette smoke, and smoking is a risk factor for several corneal diseases including dry eye syndrome. Currently, heated tobacco products (HTPs) are widely used as substitutes for cigarette smoking around th
Externí odkaz:
https://doaj.org/article/a9b5f63da0fa424e952ceb6e72ccea9c
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-16 (2021)
Abstract Background Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudative AMD. Progranulin
Externí odkaz:
https://doaj.org/article/c66eabbd3f5e430cb87178ce4cb60efb
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1790 (2022)
Non-exudative age-related macular degeneration (AMD) is an irreversibly progressive retinal degenerative disease characterized by dysfunction and loss of retinal pigment epithelium (RPE). It has been suggested that impaired phagocytosis of the RPE is
Externí odkaz:
https://doaj.org/article/8ed21019e1134242b36e0f6d633ba0a6