Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Wataru Obuchi"'
Autor:
Eisuke Miyauchi, Takuya Furuta, Sumio Ohtsuki, Masanori Tachikawa, Yasuo Uchida, Hemragul Sabit, Wataru Obuchi, Tomoko Baba, Michitoshi Watanabe, Tetsuya Terasaki, Mitsutoshi Nakada
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193799 (2018)
Molecular biomarkers in blood are needed to aid the early diagnosis and clinical assessment of glioblastoma (GBM). Here, in order to identify biomarker candidates in plasma of GBM patients, we performed quantitative comparisons of the plasma proteome
Externí odkaz:
https://doaj.org/article/dde1772dffef4d34914522728c819b80
Autor:
Tomoyo Honda, Wataru Obuchi, Yumi Nishiya, Takahiro Shibayama, Kengo Watanabe, Nobuaki Watanabe
Publikováno v:
Biopharmaceutics & Drug Disposition. 43:213-217
The estimation of the contributions of UDP-glucuronosyl transferase (UGT) isoforms to the overall metabolism still suffers from technical difficulties due to limited information on enzyme levels in recombinant systems and specific inhibitors, unlike
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41e62b10a1abb0aedf42475d89168b7
https://doi.org/10.1002/bdd.2330
https://doi.org/10.1002/bdd.2330
Recently, we demonstrated that asymmetrical 18 base-paired double-strand oligonucleotides comprised of alternately combined 2’-O-methyl RNA and DNA, termed MED-siRNAs, show high RNase resistance, efficient cleavage of target mRNA, and the subsequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d5d888ff9ff8e095f30ab63701aafc
Autor:
Hiroyuki Ichida, Tatsuki Fukami, Keito Amai, Kohei Suzuki, Kenji Mishiro, Shiori Takano, Wataru Obuchi, Zhengyu Zhang, Akiko Watanabe, Masataka Nakano, Kengo Watanabe, Miki Nakajima
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals.
Enzymes of the aldo-keto reductase (AKR) and short-chain dehydrogenase/reductase superfamilies are involved in the reduction of compounds containing a ketone group. In most cases, multiple isoforms appear to be involved in the reduction of a compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759f51b9f13da90fedcf80a9bf838fa0
https://pubmed.ncbi.nlm.nih.gov/36310032
https://pubmed.ncbi.nlm.nih.gov/36310032
Autor:
Masakazu Tamura, Makoto Koizumi, Hiroaki Maeda, Akiko Kurimoto, Yasuhide Hirota, Wataru Obuchi, Makiko Nakayama, Hiroshi Tsuchida
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 39:292-309
Double-stranded RNAs consisting of 21-nucleotide passenger and guide strands, known as small interfering RNAs (siRNAs), can be used for the identification of gene functions and the regulation of genes involved in disease for therapeutics. The difficu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3ba3a683db4982958f3c2c150af12d
https://doi.org/10.1080/15257770.2019.1663384
https://doi.org/10.1080/15257770.2019.1663384
Autor:
Makoto, Koizumi, Yasuhide, Hirota, Makiko, Nakayama, Masakazu, Tamura, Wataru, Obuchi, Akiko, Kurimoto, Hiroshi, Tsuchida, Hiroaki, Maeda
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 39(1-3)
Double-stranded RNAs consisting of 21-nucleotide passenger and guide strands, known as small interfering RNAs (siRNAs), can be used for the identification of gene functions and the regulation of genes involved in disease for therapeutics. The difficu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c4707b0acac819ce12afbd4b7ab8f77
https://pubmed.ncbi.nlm.nih.gov/31509065
https://pubmed.ncbi.nlm.nih.gov/31509065
Autor:
Yuki Katsukura, Yasuo Uchida, Junichi Kamiie, Kenji Nakamura, Tetsuya Terasaki, Chise Tateno, Wataru Obuchi, Hirotaka Kawakami, Tae Inoue, Sumio Ohtsuki, Toru Horie
Publikováno v:
Drug Metabolism and Disposition. 42:1039-1043
Chimeric mice with humanized liver (PXB mice) have been generated by transplantation of urokinase-type plasminogen activator/severe combined immunodeficiency mice with human hepatocytes. The purpose of the present study was to clarify the protein exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c194e85061db99cffe10346d40b05e55
https://doi.org/10.1124/dmd.114.057646
https://doi.org/10.1124/dmd.114.057646
Autor:
Kenji Nakamura, Mio Hirayama-Kurogi, Shingo Ito, Takuya Kuno, Toshihiro Yoneyama, Wataru Obuchi, Tetsuya Terasaki, Sumio Ohtsuki
Publikováno v:
PROTEOMICS. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31b06a09c9ecefd0bcd55828585d1bd3
https://doi.org/10.1002/pmic.201670140
https://doi.org/10.1002/pmic.201670140
Publikováno v:
Molecular Pharmacology. 83:490-500
Membrane transporter proteins may influence the sensitivity of cancer cells to anticancer drugs that can be recognized as substrates. The purpose of this study was to identify proteins that play a key role in the drug sensitivity of stomach and breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9534f6fa6c26173bff6b3934979f24f6
https://doi.org/10.1124/mol.112.081083
https://doi.org/10.1124/mol.112.081083
Autor:
Yasuo Uchida, Wataru Obuchi, Tetsuya Terasaki, Eisuke Miyauchi, Michitoshi Watanabe, Mitsutoshi Nakada, Takuya Furuta, Tomoko Baba, Masanori Tachikawa, Hemragul Sabit, Sumio Ohtsuki
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193799 (2018)
PLoS ONE
PLoS ONE
Molecular biomarkers in blood are needed to aid the early diagnosis and clinical assessment of glioblastoma (GBM). Here, in order to identify biomarker candidates in plasma of GBM patients, we performed quantitative comparisons of the plasma proteome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6f4688c31ae4280d1bc2deac166250
https://doi.org/10.1371/journal.pone.0193799
https://doi.org/10.1371/journal.pone.0193799