Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Wataru Muramatsu"'
Autor:
Yuya Maruyama, Yusuke Ohsawa, Takayuki Suzuki, Yuko Yamauchi, Kohsuke Ohno, Hitoshi Inoue, Akitoshi Yamamoto, Morimichi Hayashi, Yuji Okuhara, Wataru Muramatsu, Kano Namiki, Naho Hagiwara, Maki Miyauchi, Takahisa Miyao, Tatsuya Ishikawa, Kenta Horie, Mio Hayama, Nobuko Akiyama, Takatsugu Hirokawa, Taishin Akiyama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Sphingosine 1-phosphate receptor 1 (S1PR1), a G protein-coupled receptor, is required for lymphocyte trafficking, and is a promising therapeutic target in inflammatory diseases. Here, we synthesize a competitive S1PR1 antagonist, KSI-6666, t
Externí odkaz:
https://doaj.org/article/785e30ba214647e5951095171113232d
Autor:
Wataru Muramatsu, Hisashi Yamamoto
Publikováno v:
Organic Letters. 24:7194-7199
We describe the development of a reliable catalytic protocol for peptide bond formation that is generally applicable to natural and unnatural α-amino acids, β-amino acids, and peptides bearing various functional groups. A 10 mol % loading of HSi[OC
Autor:
Yasunori Iwata, Yusuke Nakade, Shinji Kitajima, Shiori Yoneda-Nakagawa, Megumi Oshima, Norihiko Sakai, Hisayuki Ogura, Koichi Sato, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Hiroka Yamazaki, Akinori Hara, Miho Shimizu, Kengo Furuichi, Masashi Mita, Kenji Hamase, Tomohiro Tanaka, Motohiro Nishida, Wataru Muramatsu, Hisashi Yamamoto, Shigeyuki Shichino, Satoshi Ueha, Kouji Matsushima, Takashi Wada
Publikováno v:
American Journal of Physiology-Renal Physiology. 322:F667-F679
d-Alanine has protective effects on I/R-induced kidney injury. d-Ala inhibits ROS production and improves mitochondrial membrane potential, resulting in reduced TEC necrosis by hypoxic stimulation. The administration of d-Ala protects the tubules fro
Autor:
Wataru Muramatsu, Hisashi Yamamoto
Publikováno v:
Chemical Science. 13:6309-6315
An economical, solvent-free, and metal-free method for peptide synthesisviaC–N bond cleavage using lactams has been developed.
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 79:382-390
Publikováno v:
ACS Catalysis. 10:9594-9603
The epimerization-free formation of peptide bonds is crucial for the development of peptide therapeutics and pharmaceuticals. Herein, we report a hydrosilane-mediated approach for the construction ...
Publikováno v:
Bulletin of the Chemical Society of Japan. 93:759-767
An account of the development of Lewis-acid-catalyzed methods for racemization-free peptide synthesis is presented. These methods are based on the substrate control concept that has been exploited ...
Autor:
Hisashi Yamamoto, Wataru Muramatsu
Publikováno v:
Journal of the American Chemical Society. 141:18926-18931
A tantalum-catalyzed solvent-free approach for the construction of amide bonds with 1-(trimethylsilyl)imidazole is developed, and the mild reaction conditions are applicable to a wide variety of electrophilic amino acid homologues. This approach deli
Publikováno v:
Chemical communications (Cambridge, England). 57(52)
The development of methods for amide bond formation without recourse to typical condensation reagents has become an emerging research area and has been actively explored in the past quarter century. Inspired by the structure of vitamin B12, we have d
Autor:
Hisashi Yamamoto, Wataru Muramatsu
Publikováno v:
Journal of the American Chemical Society. 143(18)
A one-pot peptide bond-forming reaction has been developed using unprotected amino acids and peptides. Two different silylating reagents, HSi[OCH(CF3)2]3 and MTBSTFA, are instrumental for the successful implementation of this approach, being used for