Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Wataru Kamoshima"'
Autor:
Wataru Kamoshima, Takaaki Obata, Shuichi Nakazawa, Akihito Ogata, Hideaki Mori, Takashi Kondo, Hisao Nakai, Masaaki Toda, Setsuko Fujita, Kouichiro Terai, Satoshi Itadani, Yoshitaka Nishita, Hiroyuki Ohno, Nagashige Omawari, Toshiaki Matsui, Masaru Sakai, Hiroshi Tsuruta
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:3787-3805
Design and synthesis of metabolically stabilized inhibitors of TNF-α production, which could be new drug candidates, are reported. Conformational analysis of an active diastereoisomer was performed based on biological evaluations of the conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d76cf58d7c7613fc625075b7fc98600
https://doi.org/10.1016/s0968-0896(02)00380-2
https://doi.org/10.1016/s0968-0896(02)00380-2
Autor:
Akihito Ogata, Shuichi Nakazawa, Masaaki Toda, Masaru Sakai, Takaaki Obata, Shingo Nakatani, Takashi Kondo, Nagashige Omawari, Wataru Kamoshima, Toshiaki Matsui, Yoshitaka Nishita, Kouichiro Terai, Satoshi Itadani, Hideaki Mori, Hisao Nakai, Hiroyuki Ohno
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:3757-3786
Discovery of new chemical leads of inhibitors for TNF-α production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-α exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04590084d29770666fa5f653938f0042
https://doi.org/10.1016/s0968-0896(02)00381-4
https://doi.org/10.1016/s0968-0896(02)00381-4
Publikováno v:
Neurochemistry International. 30:305-311
To clarify the mechanisms of nitric oxide (NO)-induced cell death in human neuronal cells, we examined effects of NO donors such as sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) on activities of glyceraldehyde-3-phosphate dehy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec5772f79327f15feb873fea37bddff
https://doi.org/10.1016/s0197-0186(96)00091-5
https://doi.org/10.1016/s0197-0186(96)00091-5
Autor:
Toshiaki, Matsui, Takashi, Kondo, Yoshitaka, Nishita, Satoshi, Itadani, Shingo, Nakatani, Nagashige, Omawari, Masaru, Sakai, Shuichi, Nakazawa, Akihito, Ogata, Hideaki, Mori, Kouichiro, Terai, Wataru, Kamoshima, Hiroyuki, Ohno, Takaaki, Obata, Hisao, Nakai, Masaaki, Toda
Publikováno v:
Bioorganicmedicinal chemistry. 10(12)
Discovery of new chemical leads of inhibitors for TNF-alpha production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::face4cd8ade7f7100e3ce41b224977a4
https://pubmed.ncbi.nlm.nih.gov/12413832
https://pubmed.ncbi.nlm.nih.gov/12413832
Autor:
Masaru Sakai, Masaaki Toda, Nagashige Omawari, Hisao Nakai, Kazunori Nakamura, Hiroyuki Ohno, Toshiaki Matsui, Shinya Takahashi, Naoki Matsunaga, Wataru Kamoshima, Takaaki Obata, Kouichiro Terai
Publikováno v:
Bioorganicmedicinal chemistry. 10(12)
2-(Acylamino)benzylphosphonic acid 6 derived from an artificial substrate of sphingomyelinase was found to show inhibitory activity of TNF-alpha production. Structural optimization was started with the chemical modification of 6. The discovery of ano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0643d89ae6f90696f7413bc93ea012c7
https://pubmed.ncbi.nlm.nih.gov/12413834
https://pubmed.ncbi.nlm.nih.gov/12413834
Publikováno v:
Neurochemistry international. 32(1)
In human neuroblastoma SH-SY5Y cells, S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide (NO)-donor, caused cell death accompanying p53 expression, nucleosomal DNA fragmentation and cell death. In addition, SNAP-induced cell death and DNA fragmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85be17b535ddc0f5860ad59e88f43065
https://pubmed.ncbi.nlm.nih.gov/9460707
https://pubmed.ncbi.nlm.nih.gov/9460707
Autor:
Takashi Taniguchi, Yasuyuki Nomura, Wataru Kamoshima, Yasuji Matsuoka, Shun Shimohama, Yoshihisa Kitamura
Publikováno v:
Biochemical and biophysical research communications. 232(2)
Recent studies suggest that cortical neurons and glial cells undergo apoptosis in Alzheimer's disease (AD). Since the protein p53 is known to induce apoptosis, we assessed p53 in postmortem samples from normal human and AD brains using specific antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef9b195751a7a2b6b6549702c60606d
https://pubmed.ncbi.nlm.nih.gov/9125193
https://pubmed.ncbi.nlm.nih.gov/9125193