Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Wataru Kakegawa"'
Autor:
Ken-ichi Dewa, Nariko Arimura, Wataru Kakegawa, Masayuki Itoh, Toma Adachi, Satoshi Miyashita, Yukiko U. Inoue, Kento Hizawa, Kei Hori, Natsumi Honjoya, Haruya Yagishita, Shinichiro Taya, Taisuke Miyazaki, Chika Usui, Shoji Tatsumoto, Akiko Tsuzuki, Hirotomo Uetake, Kazuhisa Sakai, Kazuhiro Yamakawa, Takuya Sasaki, Jun Nagai, Yoshiya Kawaguchi, Masaki Sone, Takayoshi Inoue, Yasuhiro Go, Noritaka Ichinohe, Kozo Kaibuchi, Masahiko Watanabe, Schuichi Koizumi, Michisuke Yuzaki, Mikio Hoshino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In the central nervous system, astrocytes enable appropriate synapse function through glutamate clearance from the synaptic cleft; however, it remains unclear how astrocytic glutamate transporters function at peri-synaptic contact. Here, we
Externí odkaz:
https://doaj.org/article/5cea2b1c16ce4725914dba62e22243c1
Autor:
Kento Ojima, Wataru Kakegawa, Tokiwa Yamasaki, Yuta Miura, Masayuki Itoh, Yukiko Michibata, Ryou Kubota, Tomohiro Doura, Eriko Miura, Hiroshi Nonaka, Seiya Mizuno, Satoru Takahashi, Michisuke Yuzaki, Itaru Hamachi, Shigeki Kiyonaka
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cell-type-specific activation of receptors is desirable for elucidating their roles in tissues or animals. Here, the authors developed a chemogenetic method for direct activation of mGlu1, a GPCR-type glutamate receptor subtype, and demonstrate its u
Externí odkaz:
https://doaj.org/article/cd76cfd6d6cb4625a26a3214108f2c32
Publikováno v:
Communicative & Integrative Biology, Vol 12, Iss 1, Pp 34-37 (2019)
In the central nervous system, activity-dependent endocytosis of postsynaptic AMPA-type glutamate receptors (AMPA receptors) is thought to mediate long-term depression (LTD), which is a synaptic plasticity model in various neuronal circuits. However,
Externí odkaz:
https://doaj.org/article/2978592da2ef4ee1ab3a95edf5f3a1eb
Autor:
Atsuki Kawamura, Yuta Katayama, Wataru Kakegawa, Daisuke Ino, Masaaki Nishiyama, Michisuke Yuzaki, Keiichi I. Nakayama
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108932- (2021)
Summary: Mutations in the gene encoding the chromatin remodeler chromodomain helicase DNA-binding protein 8 (CHD8) are a highly penetrant risk factor for autism spectrum disorder (ASD). Although cerebellar abnormalities have long been thought to be r
Externí odkaz:
https://doaj.org/article/bd1a938c7cc240e8a83c19cfb45ff672
Autor:
Noumeira Hamoud, Viviane Tran, Takahiro Aimi, Wataru Kakegawa, Sylvie Lahaie, Marie-Pier Thibault, Ariane Pelletier, G. William Wong, In-San Kim, Artur Kania, Michisuke Yuzaki, Michel Bouvier, Jean-François Côté
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Myoblast fusion is an essential step in muscle growth and regeneration, and is regulated by the G-protein coupled receptor (GPCR) BAI3. Here Hamoud et al. show that the GPCR activity of BAI3 is spatiotemporally regulated during myoblast fusion, and i
Externí odkaz:
https://doaj.org/article/97e34f01ba7746fbbf62f89e3ee24f73
Autor:
Sho Wakayama, Shigeki Kiyonaka, Itaru Arai, Wataru Kakegawa, Shinji Matsuda, Keiji Ibata, Yuri L. Nemoto, Akihiro Kusumi, Michisuke Yuzaki, Itaru Hamachi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Visualizing neurotransmitter receptor traffic is fundamental to understanding brain functions, but the current imaging methods can compromise the process. Here, the authors synthesize small fluorescent probes to label endogenous glutamate receptors i
Externí odkaz:
https://doaj.org/article/7eea3380bd2546d2924bb2c3f664fc62
Autor:
Shintaro Saegusa, Masahiro Fukaya, Wataru Kakegawa, Manabu Tanaka, Osamu Katsumata, Takeyuki Sugawara, Yoshinobu Hara, Makoto Itakura, Tadashi Okubo, Toshiya Sato, Michisuke Yuzaki, Hiroyuki Sakagami
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216960 (2019)
ADP ribosylation factor 6 (Arf6) is a small GTPase that regulates various neuronal events including formation of the axon, dendrites and dendritic spines, and synaptic plasticity through actin cytoskeleton remodeling and endosomal trafficking. EFA6C,
Externí odkaz:
https://doaj.org/article/4c0abf6b9e874d7b91bbbfce6a46dbe6
Autor:
Tetsushi Sadakata, Wataru Kakegawa, Yo Shinoda, Mayu Hosono, Ritsuko Katoh-Semba, Yukiko Sekine, Yumi Sato, Chihiro Saruta, Yasuki Ishizaki, Michisuke Yuzaki, Masami Kojima, Teiichi Furuichi
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99524 (2014)
Ca2+-dependent activator protein for secretion 2 (CAPS2) is a protein that is essential for enhanced release of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) from cerebellar granule cells. We previously identified dex3, a rare al
Externí odkaz:
https://doaj.org/article/428e526d7b8d4bd2ac50337e2309ab46
Autor:
Hiroshi Nonaka, Takeharu Mino, Seiji Sakamoto, Jae Hoon Oh, Yu Watanabe, Mamoru Ishikawa, Akihiro Tsushima, Kazuma Amaike, Shigeki Kiyonaka, Tomonori Tamura, A. Radu Aricescu, Wataru Kakegawa, Eriko Miura, Michisuke Yuzaki, Itaru Hamachi
Publikováno v:
Chem. 9(2):523-540
Various small molecules have been used as functional probes for tissue imaging in medical diagnosis and pharmaceutical drugs for disease treatment. The spatial distribution, target selectivity, and diffusion/excretion kinetics of small molecules in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d25746fbc9746c96a025559845a21c9
http://hdl.handle.net/2433/279237
http://hdl.handle.net/2433/279237
Autor:
Hiroshi Nonaka, Seiji Sakamoto, Kazuki Shiraiwa, Mamoru Ishikawa, Tomonori Tamura, Kyohei Okuno, Takumi Kondo, Shigeki Kiyonaka, Susaki, Etsuo A., Chika Shimizu, Ueda, Hiroki R., Wataru Kakegawa, Itaru Arai, Michisuke Yuzaki, Itaru Hamachi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 2/6/2024, Vol. 121 Issue 6, p1-12, 69p