Interplay between SMAD2 and STAT5A is a critical determinant of IL-17A/IL-17F differential expression

Autor: Karla Fabiola Corral-Jara, Camille Chauvin, Wassim Abou-Jaoudé, Maximilien Grandclaudon, Aurélien Naldi, Vassili Soumelis, Denis Thieffry

Publikováno v: Molecular Biomedicine, Vol 2, Iss 1, Pp 1-16 (2021)

Abstract Interleukins (IL)-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-helper (Th) cells, but the underlying mechan

Externí odkaz: https://doaj.org/article/12305458a27c4a008a2cff8ad8d21439

Logical Modeling and Analysis of Cellular Regulatory Networks With GINsim 3.0

Autor: Aurélien Naldi, Céline Hernandez, Wassim Abou-Jaoudé, Pedro T. Monteiro, Claudine Chaouiya, Denis Thieffry

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

The logical formalism is well adapted to model large cellular networks, in particular when detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementin

Externí odkaz: https://doaj.org/article/6cbd5b3b958943c6b18a5fa6303b403e

A theoretical exploration of birhythmicity in the p53-Mdm2 network.

Autor: Wassim Abou-Jaoudé, Madalena Chaves, Jean-Luc Gouzé

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e17075 (2011)

Experimental observations performed in the p53-Mdm2 network, one of the key protein modules involved in the control of proliferation of abnormal cells in mammals, revealed the existence of two frequencies of oscillations of p53 and Mdm2 in irradiated

Externí odkaz: https://doaj.org/article/ab38a12a7f4e4553b736afd0bcca1fd8

Contribution of ROS and metabolic status to neonatal and adult CD8 + T cell activation

Autor: Denis Thieffry, Céline Hernandez, María Angélica Santana, Otoniel Rodríguez-Jorge, Wassim Abou-Jaoudé, José Antonio Sánchez-Villanueva, Aurélien Naldi, Gabriela Rosas Salgado, Oscar Ramírez-Pliego

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (12), pp.e0226388. ⟨10.1371/journal.pone.0226388⟩
PLoS ONE, Vol 14, Iss 12, p e0226388 (2019)
PLoS ONE, 2019, 14 (12), pp.e0226388. ⟨10.1371/journal.pone.0226388⟩

International audience; In neonatal T cells, a low response to infection contributes to a high incidence of morbidity and mortality of neonates. Here we have evaluated the impact of the cytoplasmic and mitochondrial levels of Reactive Oxygen Species

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923ace7675cd94a8845d4d5e2e4222a1
https://www.hal.inserm.fr/inserm-02428783/document

Cooperation between T cell receptor and Toll-like receptor 5 signaling for CD4 + T cell activation

Autor: María Angélica Santana, Morgane Thomas-Chollier, Céline Hernandez, Linda A Kempis-Calanis, Denis Thieffry, Salvatore Spicuglia, Oscar Ramírez-Pliego, Wassim Abou-Jaoudé, Otoniel Rodríguez-Jorge, Darely Y. Gutiérrez-Reyna

Publikováno v: Science Signaling
Science Signaling, 2019, 12 (577), pp.eaar3641. ⟨10.1126/scisignal.aar3641⟩
Science Signaling, American Association for the Advancement of Science, 2019, 12 (577), pp.eaar3641. ⟨10.1126/scisignal.aar3641⟩

International audience; CD4 + T cells recognize antigens through their T cell receptors (TCRs); however, additional signals involving co-stimulatory receptors, for example CD28, are required for proper T cell activation. Alternative co-stimulatory re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c51bc34e17a5f0492f7863c2ff7ae5
https://amu.hal.science/hal-02154906/document