Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Wassim, El Nemer"'
Publikováno v:
Bulletins et Mémoires de la Société d’Anthropologie de Paris, Vol 36 (2023)
Externí odkaz:
https://doaj.org/article/13360655c3f34b7496096f88d3c148bf
Autor:
Panagiotis Antoniou, Giulia Hardouin, Pierre Martinucci, Giacomo Frati, Tristan Felix, Anne Chalumeau, Letizia Fontana, Jeanne Martin, Cecile Masson, Megane Brusson, Giulia Maule, Marion Rosello, Carine Giovannangeli, Vincent Abramowski, Jean-Pierre de Villartay, Jean-Paul Concordet, Filippo Del Bene, Wassim El Nemer, Mario Amendola, Marina Cavazzana, Anna Cereseto, Oriana Romano, Annarita Miccio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Antoniou and colleagues used base editing to generate a variety of mutations inducing γ-globin and rescue the β-hemoglobinopathy phenotype. This strategy was safe and effective in long-term repopulating hematopoietic stem/progenitor cells.
Externí odkaz:
https://doaj.org/article/313aa0fc4a794f6798f4ea808d498494
Autor:
Enrica Federti, Alessandro Matte, Antonio Recchiuti, Francesca Garello, Alessandra Ghigo, Wassim El Nemer, Enzo Terreno, Angela Amoresano, Domenico Mattoscio, Franco Turrini, Christophe Lebouef, Anne Janin, Antonella Pantaleo, Roberta Russo, Mickael Marin, Iana Iatcencko, Veronica Riccardi, Angela Siciliano, Achille Iolascon, Carlo Brugnara, Lucia De Franceschi
Publikováno v:
HemaSphere, Vol 7, Iss 3, p e848 (2023)
Drug repurposing is a valuable strategy for rare diseases. Sickle cell disease (SCD) is a rare hereditary hemolytic anemia accompanied by acute and chronic painful episodes, most often in the context of vaso-occlusive crisis (VOC). Although progress
Externí odkaz:
https://doaj.org/article/c8c05eebb53a44d484b867d2b88dc0d7
Autor:
Alexis Caulier, Nicolas Jankovsky, Emilie Fleur Gautier, Wassim El Nemer, Corinne Guitton, Hakim Ouled-Haddou, François Guillonneau, Patrick Mayeux, Virginie Salnot, Johanna Bruce, Véronique Picard, Loïc Garçon
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Hereditary xerocytosis is a dominant red cell membrane disorder characterized by an increased leak of potassium from the inside to outside the red blood cell membrane, associated with loss of water leading to red cell dehydration and chronic hemolysi
Externí odkaz:
https://doaj.org/article/41d3e8f282a840d9adfbdf38314def55
Publikováno v:
HemaSphere, Vol 6, Iss 9, p e762 (2022)
Sickle cell disease (SCD) is characterized by variable clinical outcomes, with some patients suffering life-threatening complications during childhood, and others living relatively symptom-free into old age. Because of this variability, there is an i
Externí odkaz:
https://doaj.org/article/a8bd78abc87f4511b3164f401de81056
Autor:
Tieying Xu, Maria A. Lizarralde-Iragorri, Benoit Charlot, Jean Roman, Olivier Français, Wassim El Nemer, Bruno Le Pioufle
Publikováno v:
Biosensors and Bioelectronics: X, Vol 10, Iss , Pp 100140- (2022)
In this paper, sickled red blood cells of different densities from distinct Sickle Cell Disease (SCD) patients were analyzed, using a microfluidic device based on bioimpedance sensing. Complementary to our previous work (Xu et al., 2020) demonstratin
Externí odkaz:
https://doaj.org/article/83bfaa4f6c0e4e56916d9fc27ed3e88c
Autor:
Pedro L. Moura, Maria A. Lizarralde Iragorri, Olivier Français, Bruno Le Pioufle, Johannes G.G. Dobbe, Geert J. Streekstra, Wassim El Nemer, Ashley M. Toye, Timothy J. Satchwell
Publikováno v:
Blood Advances, Vol 3, Iss 17, Pp 2653-2663 (2019)
Abstract: The capacity to undergo substantial deformation is a defining characteristic of the red blood cell (RBC), facilitating transit through the splenic interendothelial slits and microvasculature. Establishment of this remarkable property occurs
Externí odkaz:
https://doaj.org/article/b63006dd41a14eda93dd7bc04777885b
Autor:
Sara El Hoss, Sylvie Cochet, Mickaël Marin, Claudine Lapouméroulie, Michael Dussiot, Naïm Bouazza, Caroline Elie, Mariane de Montalembert, Cécile Arnaud, Corinne Guitton, Béatrice Pellegrino, Marie Hélène Odièvre, Frédérique Moati, Caroline Le Van Kim, Yves Colin Aronovicz, Wassim El Nemer, Valentine Brousse
Publikováno v:
Blood Advances, Vol 3, Iss 15, Pp 2328-2336 (2019)
Abstract: Spleen dysfunction is central to morbidity and mortality in children with sickle cell anemia (SCA). The initiation and determinants of spleen injury, including acute splenic sequestration (ASS) have not been established. We investigated spl
Externí odkaz:
https://doaj.org/article/689d734e554b4a85bbc751b1ba0bcfcf
Autor:
Maria Alejandra Lizarralde-Iragorri, Sophie D. Lefevre, Sylvie Cochet, Sara El Hoss, Valentine Brousse, Anne Filipe, Michael Dussiot, Slim Azouzi, Caroline Le Van Kim, Fernando Rodrigues-Lima, Olivier Français, Bruno Le Pioufle, Thomas Klei, Robin van Bruggen, Wassim El Nemer
Publikováno v:
Haematologica, Vol 106, Iss 9 (2020)
Vaso-occlusive crises are the hallmark of sickle cell disease (SCD). They are believed to occur in two steps, starting with adhesion of deformable low-dense red blood cells (RBCs), or other blood cells such as neutrophils, to the wall of post-capilla
Externí odkaz:
https://doaj.org/article/f8e47790cc614bceaf1a6c86c6db0d5f
Autor:
Sara El Hoss, Sylvie Cochet, Auria Godard, Hongxia Yan, Michaël Dussiot, Giacomo Frati, Bénédicte Boutonnat-Faucher, Sandrine Laurance, Olivier Renaud, Laure Joseph, Annarita Miccio, Valentine Brousse, Mohandas Narla, Wassim El Nemer
Publikováno v:
Haematologica, Vol 106, Iss 10 (2020)
While ineffective erythropoiesis has long been recognized as a key contributor to anemia in thalassemia, its role in anemia of sickle cell disease (SCD) has not been critically explored. Using in vitro and in vivo derived human erythroblasts we asses
Externí odkaz:
https://doaj.org/article/aaaa847b38394956a803db1d63a540dd