Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas.

Autor: Koncar RF; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Dey BR; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; SUNY Downstate Medical Center, New York, New York., Stanton AJ; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Agrawal N; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania., Wassell ML; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., McCarl LH; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Locke AL; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania., Sanders L; Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California., Morozova-Vaske O; Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California.; University of California Santa Cruz Genomics Institute, Santa Cruz, California., Myers MI; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania., Hamilton RL; Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania., Carcaboso AM; Institut de Recerca Sant Joan de Deu, Barcelona, Spain., Kohanbash G; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Hu B; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Amankulor NM; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Felker J; Pediatric Neuro-Oncology Program, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania., Kambhampati M; Children's National Health System, Washington, D.C.; Department of Genomics and Precision Medicine, George Washington University School of Medicine and Health Sciences, Washington, D.C., Nazarian J; Children's National Health System, Washington, D.C.; Department of Genomics and Precision Medicine, George Washington University School of Medicine and Health Sciences, Washington, D.C.; Department of Oncology, University Children's Hospital Zürich, Zürich, Switzerland., Becher OJ; Division of Hematology, Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.; Department of Biochemistry and Molecular Genetics, Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois., James CD; Department of Biochemistry and Molecular Genetics, Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.; Department of Neurological Surgery, Robert H. Lurie NCI Comprehensive Cancer Center, Northwestern University, Chicago, Illinois.; Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Hashizume R; Department of Biochemistry and Molecular Genetics, Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.; Department of Neurological Surgery, Robert H. Lurie NCI Comprehensive Cancer Center, Northwestern University, Chicago, Illinois.; Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Broniscer A; Pediatric Neuro-Oncology Program, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania., Pollack IF; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Agnihotri S; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania. sameer.agnihotri@pitt.edu.; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Publikováno v: Cancer research [Cancer Res] 2019 Aug 15; Vol. 79 (16), pp. 4026-4041. Date of Electronic Publication: 2019 Jun 14.