Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

Autor: Alton, Eric WFW, Beekman, Jeffery M, Boyd, A Christopher, Brand, June, Carlon, Marianne, Connolly, Mary M, Chan, Mario, Conlon, Sinead, Davidson, Heather E, Davies, Jane C, Davies, Lee A, Dekkers, Johanna F, Doherty, Ann, Gea-Sorli, Sabrina, Gill, Deborah R, Griesenbach, Uta, Hasegawa, Mamoru, Higgins, Tracy E, Hironaka, Takashi, Hyndman, Laura, McLachlan, Gerry, Inoue, Makoto, Hyde, Stephen C, Innes, J Alastair, Maher, Toby M, Moran, Caroline, Meng, Cuixiang, Paul-Smith, Michael C, Pringle, Ian A, Pytel, Kamila M, Rodriguez-Martinez, Andrea, Schmidt, Alexander C, Stevenson, Barbara J, Sumner-Jones, Stephanie G, Toshner, Richard, Tsugumine, Shu, Wasowicz, Marguerite W, Zhu, Jie

Publikováno v: Alton, E WFW, Beekman, J M, Boyd, A C, Brand, J, Carlon, M S, Connolly, M M, Chan, M, Conlon, S, Davidson, H, Davies, J C, Davies, L A, Dekkers, J F, Doherty, A, Gea-sorli, S, Gill, D R, Griesenbach, U, Hasegawa, M, Higgins, T E, Hironaka, T, Hyndman, L, McLachlan, G, Inoue, M, Hyde, S C, Innes, J A, Maher, T M, Moran, C, Meng, C, Paul-Smith, M C, Pringle, I A, Pytel, K M, Rodriguez-Martinez, A, Schmidt, A C, Stevenson, B, Sumner-Jones, S G, Toshner, R, Tsugumine, S, Wasowicz, M W & Zhu, J 2017, ' Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis ', Thorax, vol. 72, no. 2, pp. 137-147 . https://doi.org/10.1136/thoraxjnl-2016-208406
Thorax

We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemaggluti

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https://ora.ox.ac.uk/objects/uuid:06e16f3b-e8eb-4ccb-b37f-5e85a5a75530

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