Multidisciplinary considerations for implementing Bayesian borrowing in basket trials.

Autor: Broglio KR; Oncology Statistical Innovation, AstraZeneca Pharmaceuticals, Gaithersburg, MD, USA. Electronic address: kristine.broglio@astrazeneca.com., Blau JE; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Pilling EA; Biometrics, Late-stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wason JMS; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.

Publikováno v: Drug discovery today [Drug Discov Today] 2024 Sep; Vol. 29 (9), pp. 104127. Date of Electronic Publication: 2024 Aug 02.

Challenges of designing and conducting cohort studies and clinical trials in populations of pregnant people.

Autor: Schreiber K; Danish Centre for Expertise in Rheumatology (CeViG), Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; Thrombosis and Haemostasis, Guy's and St Thomas' NHS Foundation Trust, London, UK. Electronic address: kschreiber@danskgigthospital.dk., Graversgaard C; Danish Centre for Expertise in Rheumatology (CeViG), Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark; Department of Rheumatology, Århus University Hospital, Århus, Denmark., Hunt BJ; Thrombosis and Haemostasis, Guy's and St Thomas' NHS Foundation Trust, London, UK., Wason JMS; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Costedoat-Chalumeau N; Centre de référence maladies auto-immunes et systémiques rares de l'île de France, Cochin Hospital, Paris, France; Université Paris Cité, Paris, France; Center Of Research In Epidemiology And Statistics, Inserm University, Paris, France., Aguilera S; Spanish Association for Antiphospholipid Syndrome, Elche, Spain., Guerra MM; Hospital for Special Surgery, New York, NY, USA., Salmon JE; Hospital for Special Surgery, New York, NY, USA; Weill Cornell Medicine, New York, NY, USA.

Publikováno v: The Lancet. Rheumatology [Lancet Rheumatol] 2024 Aug; Vol. 6 (8), pp. e560-e572. Date of Electronic Publication: 2024 Jun 11.

Pulmonary Hypertension: Intensification and Personalization of Combination Rx (PHoenix): A phase IV randomized trial for the evaluation of dose-response and clinical efficacy of riociguat and selexipag using implanted technologies.

Autor: Varian F; Division of Clinical Medicine University of Sheffield Sheffield UK.; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Dick J; Division of Clinical Medicine University of Sheffield Sheffield UK., Battersby C; Division of Clinical Medicine University of Sheffield Sheffield UK., Roman S; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Ablott J; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Watson L; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Binmahfooz S; Division of Clinical Medicine University of Sheffield Sheffield UK., Zafar H; Division of Clinical Medicine University of Sheffield Sheffield UK.; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Colgan G; Royal Free NHS Foundation Trust London UK., Cannon J; Royal Papworth Hospital NHS Foundation Trust Cambridge UK., Suntharalingam J; Royal United Hospitals Bath NHS Foundation Trust Bath UK., Lordan J; Newcastle Hospitals NHS Foundation Trust Newcastle UK., Howard L; Imperial College Healthcare NHS Trust London UK., McCabe C; Royal Brompton and Harefield Guy's and St Thomas' NHS Foundation Trust London UK., Wort J; NHS Greater Glasgow and Clyde Glasgow UK., Price L; NHS Greater Glasgow and Clyde Glasgow UK., Church C; National Heart and Lung Institute, Faculty of Medicine, Imperial College London London UK., Hamilton N; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Armstrong I; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Hameed A; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Hurdman J; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Elliot C; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Condliffe R; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Wilkins M; National Heart and Lung Institute, Faculty of Medicine, Imperial College London London UK., Webb A; Wolfson Centre for Prevention of Stroke and Dementia University of Oxford Oxford UK., Adlam D; Cardiovascular Research Unit of Leicester Leicester UK., Benza RL; Mount Sinai Heart Icahn School of Medicine at Mount Sinai New York New York USA., Rahimi K; Deep Medicine, Nuffield Department of Women's and Reproductive Health University of Oxford Oxford UK., Shojaei-Shahrokhabadi M; Biostatistics Research Group, Population Health Sciences Institute Newcastle University Newcastle upon Tyne UK., Lin NX; Biostatistics Research Group, Population Health Sciences Institute Newcastle University Newcastle upon Tyne UK., Wason JMS; Biostatistics Research Group, Population Health Sciences Institute Newcastle University Newcastle upon Tyne UK., McIntosh A; Robertson Centre for Biostatistics, School of Health and Wellbeing University of Glasgow Glasgow UK., McConnachie A; Robertson Centre for Biostatistics, School of Health and Wellbeing University of Glasgow Glasgow UK., Middleton JT; Division of Clinical Medicine University of Sheffield Sheffield UK.; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Thompson R; Division of Clinical Medicine University of Sheffield Sheffield UK.; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Kiely DG; Division of Clinical Medicine University of Sheffield Sheffield UK.; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK., Toshner M; Department of Medicine, Heart and Lung Research Institute University of Cambridge Cambridge UK., Rothman A; Division of Clinical Medicine University of Sheffield Sheffield UK.; Sheffield Pulmonary Vascular Disease Unit Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK.

Publikováno v: Pulmonary circulation [Pulm Circ] 2024 Mar 17; Vol. 14 (1), pp. e12337. Date of Electronic Publication: 2024 Mar 17 (Print Publication: 2024).

Bayesian sample size determination in basket trials borrowing information between subsets.

Autor: Zheng H; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK., Grayling MJ; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK., Mozgunov P; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK., Jaki T; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK and University of Regensburg, 93040 Regensburg, Germany., Wason JMS; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK.

Publikováno v: Biostatistics (Oxford, England) [Biostatistics] 2023 Oct 18; Vol. 24 (4), pp. 1000-1016.

Bayesian borrowing for basket trials with longitudinal outcomes.

Autor: Whitehead LE; Biostatistics Research Group, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Sailer O; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany., Witham MD; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK., Wason JMS; Biostatistics Research Group, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.

Publikováno v: Statistics in medicine [Stat Med] 2023 Jul 20; Vol. 42 (16), pp. 2819-2840. Date of Electronic Publication: 2023 Apr 30.