A hybrid approach to sample size re-estimation in cluster randomized trials with continuous outcomes.

Autor: Sarkodie SK; Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom., Wason JM; Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom., Grayling MJ; Statistics and Decision Sciences, Janssen R&D, High Wycombe, United Kingdom.

Publikováno v: Statistics in medicine [Stat Med] 2024 Oct 30; Vol. 43 (24), pp. 4736-4751. Date of Electronic Publication: 2024 Aug 28.

Defining predictors of responsiveness to advanced therapies in Crohn's disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine.

Autor: Wyatt NJ; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Watson H; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Anderson CA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Kennedy NA; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Raine T; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Ahmad T; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Allerton D; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Bardgett M; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Clark E; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Clewes D; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Cotobal Martin C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Doona M; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Doyle JA; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Frith K; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Hancock HC; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Hart AL; Department of Gastroenterology, St Mark's Hospital and Academic Institute, London, UK.; Department of Surgery and Cancer, Imperial College London, London, UK., Hildreth V; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Irving PM; Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK.; School of Immunology & Microbial Sciences, King's College London, London, UK., Iqbal S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Kennedy C; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., King A; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Lawrence S; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Lees CW; Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Edinburgh IBD Unit, Western General Hospital, NHS Lothian, Edinburgh, UK., Lees R; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Letchford L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Liddle T; Research Informatics Team, Clinical Research, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Lindsay JO; Department of Gastroenterology, Barts Health NHS Trust, London, UK.; Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK., Maier RH; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Mansfield JC; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Marchesi JR; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, St Mary's Hospital, Imperial College London, London, UK., McGregor N; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., McIntyre RE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Ostermayer J; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Osunnuyi T; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Powell N; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, St Mary's Hospital, Imperial College London, London, UK.; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK., Prescott NJ; Department of Medical and Molecular Genetics, Guy's Hospital, King's College London, London, UK., Satsangi J; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Sharma S; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Shrestha T; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Speight A; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Strickland M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Wason JM; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Whelan K; Department of Nutritional Sciences, King's College London, London, UK., Wood R; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Young GR; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Zhang X; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Parkes M; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Stewart CJ; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Jostins-Dean L; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Lamb CA; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK christopher.lamb@newcastle.ac.uk.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Publikováno v: BMJ open [BMJ Open] 2024 Apr 17; Vol. 14 (4), pp. e073639. Date of Electronic Publication: 2024 Apr 17.

A hybrid approach to comparing parallel-group and stepped-wedge cluster-randomized trials with a continuous primary outcome when there is uncertainty in the intra-cluster correlation.

Autor: Sarkodie SK; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Wason JM; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Grayling MJ; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.

Publikováno v: Clinical trials (London, England) [Clin Trials] 2023 Feb; Vol. 20 (1), pp. 59-70. Date of Electronic Publication: 2022 Sep 09.

Employing a latent variable framework to improve efficiency in composite endpoint analysis.

Autor: McMenamin M; 47959MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Barrett JK; 47959MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Berglind A; Late RIA, R&D BioPharmaceuticals AstraZeneca, Gothenburg, Sweden., Wason JM; 47959MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.; Institute of Health and Society, 5994Newcastle University, Newcastle, UK.

Publikováno v: Statistical methods in medical research [Stat Methods Med Res] 2021 Mar; Vol. 30 (3), pp. 702-716. Date of Electronic Publication: 2020 Nov 24.

A latent variable model for improving inference in trials assessing the effect of dose on toxicity and composite efficacy endpoints.

Autor: Wason JM; Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Seaman SR; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

Publikováno v: Statistical methods in medical research [Stat Methods Med Res] 2020 Jan; Vol. 29 (1), pp. 230-242. Date of Electronic Publication: 2019 Feb 25.