Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Wason, James MS"'
Autor:
Grayling, Michael J, Wason, James MS
Multi-arm designs provide an effective means of evaluating several treatments within the same clinical trial. Given the large number of treatments now available for testing in many disease areas, it has been argued that their utilisation should incre
Externí odkaz:
http://arxiv.org/abs/1906.09178
Publikováno v:
Statistics in Medicine; 10/30/2024, Vol. 43 Issue 24, p4736-4751, 16p
Autor:
Cherlin, Svetlana, Bigirumurame, Theophile, Grayling, Michael J, Nsengimana, Jérémie, Ouma, Luke, Santaolalla, Aida, Wan, Fang, Williamson, S Faye, Wason, James MS
Publikováno v:
Research Methods in Medicine & Health Sciences; Sep2024, Vol. 5 Issue 4, p110-124, 15p
Publikováno v:
Statistics in Medicine.
Funder: Biometrika Trust
Platform trials evaluate multiple experimental treatments under a single master protocol, where new treatment arms are added to the trial over time. Given the multiple treatment comparisons, there is the potential for in
Platform trials evaluate multiple experimental treatments under a single master protocol, where new treatment arms are added to the trial over time. Given the multiple treatment comparisons, there is the potential for in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a4aa92232fcab4b6c0cf4a380921e3
https://doi.org/10.1002/sim.9733
https://doi.org/10.1002/sim.9733
Basket trials are an innovative precision medicine clinical trial design evaluating a single targeted therapy across multiple diseases that share a common characteristic. To date, most basket trials have been conducted in early-phase oncology setting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21847e8a50e7f6632c8c5e3b8ebd2bf
Autor:
Mossop, Helen, Grayling, Michael J, Gallagher, Ferdia A, Welsh, Sarah J, Stewart, Grant D, Wason, James MS
Funder: RCUK | MRC | Medical Research Foundation; doi: https://doi.org/10.13039/501100009187
Funder: NIHR Biomedical Research Centre BRC-1215-20014
BACKGROUND: Efficient trial designs are required to prioritise promising drugs within Phase
Funder: NIHR Biomedical Research Centre BRC-1215-20014
BACKGROUND: Efficient trial designs are required to prioritise promising drugs within Phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119a4cf8040f9ec794b151e92775ad53
Autor:
Grayling, Michael J.1 (AUTHOR) michael.grayling@newcastle.ac.uk, Wason, James MS.1,2 (AUTHOR)
Publikováno v:
BMC Cancer. 1/31/2020, Vol. 20 Issue 1, p1-12. 12p. 2 Color Photographs, 1 Chart, 1 Graph.
Bioequivalence (BE) studies are most often conducted as crossover trials, and therefore establishing their required sample size necessitates specification of the within-person variance. Given that this specification is often difficult in practice, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a8e088dcbdbd27b6ab306c324683f0
Autor:
Mossop, Helen, Grayling, Michael J, Gallagher, Ferdia, Welsh, Sarah, Stewart, Grant, Wason, James MS
BACKGROUND: Efficient trial designs are required to prioritise promising drugs within Phase II trials. Adaptive designs are examples of such designs, but their efficiency is reduced if there is a delay in assessing patient responses to treatment. MET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e8ffa7e941aed10910beb62785c98e
https://www.repository.cam.ac.uk/handle/1810/329684
https://www.repository.cam.ac.uk/handle/1810/329684
Supplemental material, sj-pdf-1-ctj-10.1177_17407745221123507 for A hybrid approach to comparing parallel-group and stepped-wedge cluster-randomized trials with a continuous primary outcome when there is uncertainty in the intra-cluster correlation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12308781aacb3362ca59ae4f5707dabf